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The Cell

A Molecular Approach

Ninth Edition

Geoffrey Cooper and Kenneth Adams

Publication Date - October 2022

ISBN: 9780197685570

816 pages


The Cell: A Molecular Approach is an ideal resource for undergraduate students in a one-semester introduction to cell biology.

The Cell: A Molecular Approach endeavors to address those issues with succinct writing, incorporation of current research, a test bank that encourages critical thinking, and an active learning framework. The text presents fundamental concepts and current research, including chapters on Genomics and Transcriptional Regulation and Epigenetics, and new in-text boxed features on Molecular Medicine and Key Experiments.

New to this Edition

  • New co-author, Kenneth Adams.
  • Learning objectives to focus students' attention.
  • Marginal notes to emphasize key points.
  • Expedited discussion of the flow of genetic information.
  • Fill in the Gaps in molecular explanations.
  • Incorporates recent discoveries and advances.
  • 16 new data analysis problems.
  • Test Bank.


  • Author created videos, integrating concept activities with instructor guide.
  • Learning objectives - each major section begins with Learning Objectives to help organize and focus students' attention on the material .
  • Summary and Questions - each major section concludes with a review, section summary, and questions, spanning several levels of Bloom's taxonomy.
  • Margin Notes - major points are summarized as margin notes throughout the text, providing a running outline of the material.
  • Illustrations and Micrographs - An illustration program of full-color art and micrographs have been developed to complement and reinforce the text.
  • Key Experiment and Molecular Medicine Essays - designed to provide students with a sense of both the experimental basis of cell and molecular biology and its application to modern medicine. These can also be used for student discussion.
  • Data Analysis Problems present data from original research papers, with questions that engage students in the analysis of experimental methods. These provide material for discussion and opportunities for active learning.
  • FYI's - Sidebars that provide descriptive highlights of points of interest.

About the Author(s)

Geoffrey Cooper is a Professor of Biology at Boston University. Receiving a Ph.D. in Biochemistry from the University of Miami in 1973, he pursued postdoctoral work with Howard Temin at the University of Wisconsin, where he developed gene transfer assays to characterize the proviral DNAs of Rous sarcoma virus and related retroviruses. He then joined the faculty of Dana-Farber Cancer Institute at Harvard Medical School in 1975, where he pioneered the discovery of oncogenes in human cancers. He moved to Boston University as Chair of Biology in 1998 and subsequently served as Associate Dean of the Faculty for Natural Sciences, as well as teaching undergraduate cell biology and continuing his research on the roles of oncogenes in the signaling pathways that regulate cell proliferation and programmed cell death. He has authored over 100 research papers, two textbooks on cancer, and an award-winning novel, The Prize, dealing with fraud in medical research.

Kenneth W. Adams is an Associate Professor of Biology at Bridgewater State University. He earned a Ph.D. in Molecu-lar Biology, Cell Biology, and Biochemistry from Boston University in 2006, where he investigated the role of Bcl-2family members in the regulation of apoptosis downstream of PI 3-kinase signaling in the lab of co-author Geoffrey M. Cooper. His subsequent postdoctoral research was con-ducted with Bradley T. Hyman at Massachusetts General Hospital, where he investigated the mechanisms through which apolipoprotein E and its receptors affect susceptibil-ity to Alzheimer’s disease. He then joined the Undergradu-ate Neuroscience Program at Boston University as a post- doctoral faculty fellow and lecturer, during which his re-search focused on the transcriptional network that drives neuronal differentiation using PC12 cells as a model. In 2013, he joined the faculty of Bridgewater State Univer-sity, where he initially continued his focus on the molecular mechanisms that mediate neuronal differentiation but has more recently returned to the Alzheimer’s work he conduct-ed during his postdoctoral research. In 2016, Kenneth was awarded the Presidential Award for Distinguished Teaching at Bridgewater State University, where he also serves as the Director of Undergraduate Research.

Table of Contents


    Chapter 1 Introduction to Cells and Cell Research

    Chapter 2 Physical Principles Underlying Cell Structure and Function

    Chapter 3 Fundamentals of Molecular Biology


    Chapter 4 Genes and Genomes

    Chapter 5 Replication, Maintenance, and Rearrangements of Genomic DNA

    Chapter 6 RNA Synthesis and Processing

    Chapter 7 Transcriptional Regulation and Epigenetics

    Chapter 8 Protein Synthesis, Processing, and Regulation

    Chapter 9 Genomics, Proteomics, and Systems Biology


    Chapter 10 The Nucleus

    Chapter 11 Protein Sorting and Transport: The Endoplasmic Reticulum, Golgi Apparatus, and Lysosomes

    Chapter 12 Mitochondria, Chloroplasts, and Peroxisomes

    Chapter 13 The Cytoskeleton and Cell Movement

    Chapter 14 The Plasma Membrane

    Chapter 15 Cell Walls, the Extracellular Matrix, and Cell Interactions

    PART IV: Cell Regulation

    Chapter 16 Cell Signaling

    Chapter 17 The Cell Cycle

    Chapter 18 Cell Renewal and Cell Death

    Chapter 19 Cancer

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