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Protecting Group Chemistry

Jeremy Robertson

Publication Date - 16 November 2000

ISBN: 9780198502753

104 pages


Number 95 in the well-known Oxford Chemistry Primer series provides an overview of methods that allow specific sites within an organic molecule to be manipulated without affecting other sites. The book emphasizes the link between the mechanisms of organic chemistry and the choice of specific protecting groups that block chemical reactivity at those sites that must remain unaffected. The treatment differs from traditional texts in that it places the emphasis on making a connection between the fundamental mechanisms of organic chemisry - ionization, substitution, addition, elimination, oxidation, and reductionand how a particular protecting group can best be selected in a given situation.


  • Introduces the concept of protecting group devices. Good mechanistic framework.
  • Grouping is by cleavage conditions, not by functional group, so that protecting groups are not dealt with in isolation.
  • Temporary protecting groups: Highlights in situ methods where the protected molecule is never actually isolated.

Table of Contents

    1. Introduction
    2. Acid-labile protecting groups
    3. Nucleophile/base-labile protecting groups
    4. Silyl protecting groups
    5. Redox deprotection

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