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Molecular Biology of Cancer

Mechanisms, Targets, and Therapeutics

Fifth Edition

Lauren Pecorino

Publication Date - August 2021

ISBN: 9780198833024

472 pages
9.7 x 7.4 inches

In Stock


Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an accessible, engaging, and optimistic account of cancer biology for undergraduate and graduate students.

Using the hallmarks of cancer as a starting point, the book looks at the cellular and molecular mechanisms underpinning the transformation of cells into cancer cells. After discussing the theory, each chapter then demonstrates how this knowledge can be directly applied to the development of new targeted therapies, giving the reader a clear appreciation of how our understanding of the theory can be translated into new approaches for tackling the disease.

The new edition draws on the latest research in cancer biology, highlighting fundamental concepts and re-emphasising pre-existing concepts. The book features a variety of learning features--'Pause and think', 'How do we know that?', self-tests and activities--to help students engage with, and master, the concepts presented. The emphasis is on acquiring a solid understanding of the essentials and an appreciation of how a theoretical understanding can be transformed into therapeutic benefit.

Molecular Biology of Cancer is available for students and institutions to purchase in a variety of formats, and is supported by online resources.

The online resources include:

For students:
- Multiple choice questions
- Web links to additional cancer biology resources

For registered adopters of the book:
· Figures from the book, available to download

New to this Edition

  • The inclusion of additional primary data from the literature provides up-to-date information about this dynamic field of research.
  • Figures to illustrate mechanisms of DNA repair.
  • New topics covered include extrachromosomal circular DNA as major sources of oncogene expression and tumor heterogeneity, the use of errors in RNA transcription and splicing as a new source of neoantigens for vaccines, the application of artificial intelligence to cancer imaging, and expanded applications of CRISPR, to name a few.
  • The expanded "Pioneers in the field" feature introduces students to thirteen inspiring molecular biologists working in the field from past to present.


  • Provides an engaging and manageable route into the complex subject of cancer biology
  • Describes the theoretical basis of cancer biology and shows how this theory is applied to develop new cancer therapies, giving students a clear appreciation of how theoretical knowledge can be translated into therapeutic strategies
  • Draws on the latest research in this dynamic field but presents it in a manner readily accessible to the student
  • Available for students and institutions to purchase in a variety of formats, and is supported by online resources.

About the Author(s)

Lauren Pecorino, Principal Lecturer in Cancer Biology, University of Greenwich

Dr Lauren Pecorino obtained her PhD in Cell and Developmental Biology at the State University of New York at Stony Brook, USA. She then moved to London to carry out a post-doctoral tenure at the Ludwig Institute for Cancer Research where she studied the phenomenon of limb regeneration. Here she used a technique called biolistics, using a 'gene gun' to shoot gold bullets coated with DNA to introduce genes into the regenerating limbs of live newts. Since 1996, Lauren has been a member of academic staff at the University of Greenwich, where she developed her interest in teaching Cancer Biology. In 2018, Lauren was made a Principal Fellow of the Higher Education Academy.

Table of Contents

    1. Introduction
    2. The cancer genome
    3. Regulation of gene expression
    4. Growth factor signaling and oncogenes
    5. The cell cycle
    6. Tumor suppressor genes
    7. Apoptosis
    8. Cancer stem cells and the regulation of self-renewal and differentiation pathways: focus on colon cancer and leukemias
    9. Metastasis
    10. Angiogenesis
    11. Reprogrammed metabolism and diet
    12. Tumor immunology and immunotherapy
    13. Inflammation, infection, and the microbiome
    14. Strategies and tools for research and drug development

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