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Molecular Biology of Cancer

Mechanisms, Targets, and Therapeutics

Fourth Edition

Lauren Pecorino

Publication Date - August 2016

ISBN: 9780198717348

368 pages
9.7 x 7.4 inches

In Stock

Retail Price to Students: $94.99

The most engaging and accessible account of cancer biology, available, this text makes the link between our understanding of cancer and the development of new therapeutics crystal clear


Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an accessible, engaging, and optimistic account of cancer biology for undergraduate and graduate students. Drawing on the latest research in this dynamic field, author Lauren Pecorino makes cutting-edge science readily accessible.

Using the hallmarks of cancer as a starting point, the text looks at the cellular and molecular mechanisms underpinning the transformation of cells into cancer cells. After discussing the theory, each chapter then demonstrates how this knowledge can be directly applied to the development of new targeted therapies, giving students a clear appreciation of how the theory translates to tackling the disease.

Molecular Biology of Cancer, Fourth Edition, features a variety of pedagogical features--"Pause and think," "How do we know that?," self-tests, and activities--to help students engage with, and master, the concepts presented. It provides students with a solid understanding of the essentials and an appreciation of how a theoretical understanding can be transformed into therapeutic benefit.

A Companion Website contains resources for instructors--downloadable figures from the book and a test bank of multiple-choice questions--and related web links for students.

New to this Edition

  • New full-color diagrams help students visualize the key concepts explained in the text more effectively
  • Expanded coverage of tumor immunology and immunotherapy that discusses the tumor-suppression and tumor-promotion mechanisms of the immune system and their exciting new applications in developing cancer immunotherapies


  • Provides an engaging and manageable entry into the complex subject of cancer biology
  • Describes the theoretical basis of cancer biology and shows how this theory is applied to develop new cancer therapies, giving students a clear appreciation of how theoretical knowledge can be translated into therapeutic strategies
  • Draws on the latest research in this dynamic field, presenting it in a manner that is readily accessible to students

About the Author(s)

Lauren Pecorino is Principal Lecturer in Cancer Biology at the University of Greenwich.

Previous Publication Date(s)

April 2012
June 2008
March 2005

Table of Contents

    1. Introduction
    2. DNA structure and stability: mutations versus repair
    3. Regulation of gene expression
    4. Growth factor signaling and oncogenes
    5. The cell cycle
    6. Growth inhibition and tumor suppressor genes
    7. Apoptosis
    8. Stem cells and consequences of blocked differentiation
    9. Metastasis
    10. Angiogenesis
    11. Nutrients, hormones, and gene interactions
    12. Tumour immunology and immunotherapy
    13. Infectious agents and inflammation
    14. New technologies and drug development