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Ion Channels of Excitable Membranes

Third Edition

Bertil Hille

Publication Date - July 2001

ISBN: 9780878933211

816 pages
7 x 9.5 inches

In Stock

Retail Price to Students: $179.99

An authoritative overview used by all neuroscientists


Ion channels underlie a broad range of the most basic biological processes, from excitation and signaling to secretion and absorption. Like enzymes, they are diverse and ubiquitous macromolecular catalysts with high substrate specificity and subject to strong regulation. This fully revised and expanded third edition of Ion Channels of Excitable Membranes describes the known channels and their physiological functions, then develops the conceptual background needed to understand their architecture and molecular mechanisms of operation. It includes new chapters on calcium signaling, structural biology, and molecular biology and genomics. Ion Channels of Excitable Membranes begins with the classical biophysical work of Hodgkin and Huxley, continues with the roles of channels in cellular signaling, then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ion Channels of Excitable Membranes is written to be accessible and interesting to life scientists and physical scientists of all kinds. It introduces all the concepts that a graduate student should be aware of but is also effective in advanced undergraduate courses. It has long been the recognized authoritative overview of this field used by all neuroscientists.

About the Author(s)

Bertil Hille is Professor in the Department of Physiology and Biophysics at the University of Washington. He graduated summa cum laude from Yale University with a B.S. in Zoology, and earned a Ph.D. in Life Sciences at The Rockefeller University. Dr. Hille then did postdoctoral work in the laboratories of A. L. Hodgkin and R. D. Keynes. He was elected to the National Academy of Sciences in 1986, and has received numerous awards, including: the Third Annual Bristol-Myers Squibb Award for Distinguished Achievement in Neuroscience Research (1990); the Columbia University Louisa Gross Horwitz Prize for Biology or Biochemistry (1996, shared with Clay Armstrong); and the Albert Lasker Basic Medical Research Award (1999, jointly with Clay Armstrong and Roderick MacKinnon). A cell physiologist, neurobiologist, and educator, Dr. Hille works on ion channel biophysics, signaling by modulatory neurotransmitters, and intracellular calcium dynamics. The Hille laboratory has published over 140 research papers and trained fifty graduate students and postdoctoral fellows.

Previous Publication Date(s)

January 1992
January 1984


"The third edition of Ion Channels of Excitable Membranes is markedly expanded, remarkably up to date, and stands as an unmitigated tour de force. Complete and enthusiastic, but not overwhelming, the text builds intuitively from the biophysical roots of the discipline. By maintaining a historical flavor, the reader is cleanly offered the essential ideas and concepts that remain key even as the field evolves. The book remains a resource for practitioners of the craft and the essential guide to the electrophysiological universe." --Steven A. N. Goldstein, Cell

Table of Contents

    1. Introduction

    PART I: Description of Channels

    2. Classical Biophysics of the Squid Giant Axon
    3. The Superfamily of Voltage-Gated Channels
    4. Voltage-Gated Calcium Channels
    5. Potassium Channels and Chloride Channels
    6. Ligand-Gated Channels of Fast Chemical Synapses
    7. Modulation, Slow Synaptic Action, and Second Messengers
    8. Sensory Transduction and Excitable Cells
    9. Calcium Dynamics, Epithelial Transport, and Intercellular Coupling

    PART II: Principles and Mechanisms of Functions

    10. Elementary Properties of Ions in Solution
    11. Elementary Properties of Pores
    12. Counting Channels and Measuring Fluctuations
    13. Structure of Channel Proteins
    14. Selective Permeability: Independence
    15. Selective Permeability: Saturation and Binding
    16. Classical Mechanisms of Block
    17. Structure-Function Studies of Permeation and Block
    18. Gating Mechanisms: Kinetic Thinking
    19. Gating: Voltage Sensing and Inactivation
    20. Modification of Gating in Voltage-Sensitive Channels
    21. Cell Biology and Channels
    22. Evolution and Origins