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Cover

Genetics and Analysis of Quantitative Traits

Michael Lynch and Bruce Walsh

Publication Date - January 1998

ISBN: 9780878934812

980 pages
Hardcover
7.5 x 9.5 inches

Retail Price to Students: $148.95

Brings together the diverse array of theoretical and empirical applications of quantitative genetics

Description

With the emerging recognition that the expression of most characters is influenced by multiple genes and multiple environmental factors, quantitative genetics has become the central paradigm for the analysis of phenotypic variation and evolution.

Genetics and Analysis of Quantitative Traits brings together the diverse array of theoretical and empirical applications of quantitative genetics under one cover, in a way that is both comprehensive and accessible to anyone with a rudimentary understanding of statistics and genetics. What was originally envisioned as a single text has now become two, with the focus of this first book being on the basic biology and methods of analysis of quantitative characters.

Three major features of Genetics and Analysis of Quantitative Traits distinguish it from earlier work. First, it reflects the explosive influx over the past few years of quantitative-genetic thinking into evolutionary biology. Second, in animal breeding, enormous strides have been made in the development of new techniques for estimating breeding values (for the purposes of identifying elite individuals in selection programs) and for estimating variance components from samples of complex pedigrees. In this text's last two chapters, the authors outline the basic principles of complex pedigree analysis, without getting bogged down in technical details. Third, Genetics and Analysis of Quantitative Traits provides a broad overview of the newly emerging array of techniques for quantitative-trait loci (QTL) analysis, currently one of the most active fields of quantitative-genetic research.

Genetics and Analysis of Quantitative Traits contains numerous fully-worked examples and illustrations of theoretical concepts, as well as over 2,000 references with indices by subject, author, and organism. In addition, the authors maintain a World Wide Web site featuring up-to-date lists of computer programs and on-line resources, and added information on various topics presented in the text.

About the Author(s)

Michael Lynch is Distinguished Professor of Biology at Indiana University.

Bruce Walsh is a Professor in the Department of Ecology and Evolutionary Biology at the University of Arizona.

Reviews

"I have nothing but the highest praise for this book, which will surely stand as the definitive treatment for many years to come. The content is comprehensive, the writing clear and concise, and the overall impression is of a masterly tour de force." --Warren J. Ewens, American Journal of Human Biology

"This important and useful book will have a permanent place on my desktop. Not only is this an essential reference book, but it is also an excellent textbook." --Christopher J. Basten, Theoretical Population Biology

"Conclusively, this book is to be highly recommended for anyone interested in a closer and clearer look at nature's most valuable beauty--its genetic variability." --Elias Anastassopoulos, Economic Botany

Table of Contents

    I. Foundations of Quantitative Genetics


    *An Overview of Quantitative Genetics

    *Properties of Distributions

    *Covariance, Regression, and Correlation

    *Properties of Single Loci

    *Sources of Genetic Variation for Multilocus Traits

    *Components of Environmental Variation

    *Resemblance between Relatives

    *Introduction to Matrix Algebra and Linear Models

    *Analysis of Line Crosses

    *Inbreeding Depression

    *Matters of Scale




    II. Quantitative Trait Loci


    Polygenes and Polygenic Mutation

    *Detecting Major Genes

    *Basic Concepts of Marker-Based Analysis

    *Mapping and Characterizing QTLs: Inbred-Line Crosses

    *Mapping and Characterizing QTLs: Outbred Populations




    III. Estimation Procedures


    Parent-Offspring Regression

    *Sib Analysis

    *Twins and Clones

    *Cross-Classified Designs

    *Correlations Between Characters

    *Genotype x Environment Interaction

    *Maternal Effects

    *Sex Linkage and Sexual Dimorphism

    *Threshold Characters

    *Estimation of Breeding Values

    *Variance-Component Estimation with Complex Pedigrees




    Appendices

    A1. Expectations, Variances and Covariances of Compound Variables

    A2. Path Analysis

    A3.  Further Topics in Matrix Algebra and Linear Models

    A4. Maximum Likelihood Estimation and Likelihood-Ratio Tests

    A5. Computing the Power of Statistical Tests

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