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Cover

Genetic Analysis

Genes, Genomes, and Networks in Eukaryotes

Third Edition

Philip Meneely

Publication Date - June 2020

ISBN: 9780198809906

496 pages
Paperback
10.4 x 7.7 inches

Retail Price to Students: $79.99

Description

How do we know what role a particular gene has? How do some genes control the expression of others? How do genes interact to form gene networks?

With its unique integration of genetics and molecular biology, Genetic Analysis probes fascinating questions such as these, detailing how our understanding of key genetic phenomena can be used to understand biological systems. Opening with a brief overview of key genetic principles, model organisms, and epigenetics, the book goes on to explore the use of gene mutations and the analysis of gene expression and activity. A discussion of the interactions of genes during suppression, synthetic enhancement, and epistasis follows, which is then expanded into a consideration of genetic networks and personal genomics.

Drawing on the latest experimental tools, including CRISPR-Cas9 genome editing, microarrays, RNAi screens, and bioinformatics approaches, Genetic Analysis provides a state-of-the-art review of the field, but in a truly student-friendly manner. It uses extended case studies and text boxes to augment the narrative, taking the reader right to the forefront of contemporary research, without losing its clarity of explanation and insight.

We are in an age where, despite knowing so much about biological systems, we are just beginning to realise how much more there is still to understand. Genetic Analysis is the ideal guide to how we can use the awesome power of molecular genetics to further our understanding.

New to this Edition

  • A new chapter on genome editing with focus on the CRISPR-Cas 9 system
  • New content on the analysis of gene activity using temperature-sensitive mutations and mosaics
  • Increased coverage of epigenetics, updated with the latest developments in the field
  • Expanded use of case studies to guide students through examples of genetic analysis
  • A new learning feature called 'Literature Link' connects the chapter content to cutting-edge research

Features

  • The logic and strategy of genetic analysis in one semester shows you how the combined power of molecular biology, genetics, and genomics can be applied to solve biological questions.
  • Uses established principles of genetics as methods to analyse larger problems in biology.
  • Illustrates the conceptual basis of key analytical tools with carefully selected examples from a range of model organisms, and encourages the reader to look beyond the examples to see how these tools can be used to probe a wide range of biological problems.
  • Covers the latest and most powerful experimental tools to provide a state-of-the-art review of the field, giving insights into gene networks and interactions.
  • Text boxes and extended case studies enable the reader to fully get to grips with how genetic tools can be used to understand biological systems.
  • The online resources feature additional materials for teachers and students, enhancing the educational value of the text.

About the Author(s)

Philip Meneely, Professor of Biology, Department of Biology, Haverford College, PA, USA

Table of Contents

    1. The Basis for Genetic Analysis
    2. Genomes, Chromosomes, and Epigenetics
    3. Model Organisms and Their Genomes
    4. Identifying and Classifying Mutants
    5. Connecting Phenotypes with DNA Sequences
    6. Mutant Phenotypes and Gene Activity
    7. Reverse Genetics: Editing genes in yeast and mice
    8. Genome Editing
    9. Genome-Wide Mutant Screens
    10. Gene Interactions: Suppressors and Synthetic Enhancers
    11. Epistasis and Genetic Pathways
    12. Pathways, Networks, and Phenotypes

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