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Cover

Developmental Biology

Eleventh Edition

Scott F. Gilbert and Michael J. F. Barresi

Publication Date - May 2016

ISBN: 9781605354705

500 pages
Hardcover
8.5 x 11 inches

In Stock

Retail Price to Students: $170.95

A classic gets a new coauthor and a new approach

Description

A classic gets a new coauthor and a new approach: Developmental Biology, Eleventh Edition, keeps the excellent writing, accuracy, and enthusiasm of the Gilbert Developmental Biology book, streamlines it, adds innovative electronic supplements, and creates a new textbook for those teaching Developmental Biology to a new generation.

Several new modes of teaching are employed in the new Gilbert and Barresi textbook. The videos explaining development--as well as those from Mary Tyler's Vade Mecum--are referenced throughout the book, and several other valuable new elements have been added.

Additional updates include:

* An increased emphasis on stem cells, which are covered extensively and early in the book.
* Sex determination and gametogenesis, instead of being near the end of the volume, are up front, prior to fertilization.
* Greatly expanded coverage of neural development, comprising a unit unto itself.
* Coverage of new experiments on morphogenesis and differentiation, as well as new techniques such as CRISPR.

For Students

Companion Website


Significantly enhanced for the eleventh edition, and referenced throughout the textbook, the Developmental Biology Companion Website provides students with a range of engaging resources, in the following categories:

* NEW Dev Tutorials: Professionally produced video tutorials, presented by the textbook's authors, reinforces key concepts.

* NEW Watch Development: Putting concepts into action, these informative videos show real-life developmental biology processes.

* Web Topics: These extensive topics provide more information for advanced students, historical, philosophical, and ethical perspectives on issues in developmental biology, and links to additional online resources.

* NEW Scientists Speak: In these question-and-answer interviews, developmental biology topics are explored by leading experts in the field.

* Plus the full bibliography of literature cited in the textbook (most linked to their PubMed citations).

DevBio Laboratory: Vade Mecum3

Included with each new copy of the textbook, Vade Mecum3 is an interactive website that helps students understand the organisms discussed in the course, and prepare them for the lab. The site includes videos of developmental processes and laboratory techniques, and has chapters on the following organisms: slime mold (Dictyostelium discoideum), planarian, sea urchin, fruit fly (Drosophila), chick, and amphibian.

For Instructors

Instructor's Resource Library (available to qualified adopters)

The Developmental Biology, Eleventh Edition, Instructor's Resource Library includes the following resources:

* NEW Developing Questions: Answers, references, and recommendations for further reading are provided so that you and your students can explore the Developing Questions that are posed throughout each chapter.

* Textbook Figures & Tables: All of the textbook's figures, photos, and tables are provided both in JPEG (high- and low-resolution) and PowerPoint formats. All images have been optimized for excellent legibility when projected in the classroom.

* Video Collection: Includes video segments depicting a wide range of developmental processes, plus segments from DevBio Laboratory: Vade Mecum3, and Differential Experessions2.

* Vade Mecum3 PowerPoints: Chick serial sections and whole mounts, provided in both labeled and unlabeled versions, for use in creating quizzes, exams, or in-class exercises.

* NEW Case Studies in Dev Bio: This new collection of case study problems accompanies the Dev Tutorials and provides instructors with ready-to-use in-class active learning exercises. The case studies foster deep learning in developmental biology by providing students an opportunity to apply course content to the critical analysis of data, to generate hypotheses, and to solve novel problems in the field. Each case study includes a PowerPoint presentation and a student handout with accompanying questions.

* Developmental Biology: A Guide for Experimental Study, Third Edition, by Mary S. Tyler: The complete lab manual, in PDF format.

About the Author(s)

Scott F. Gilbert is Howard A. Schneiderman Professor Emeritus at Swarthmore College and a Finland Distinguished Professor Emeritus at the University of Helsinki Institute of Biotechnology. He teaches developmental biology, developmental genetics, and the history of biology. After receiving his B.A. from Wesleyan University, he pursued his graduate and postdoctoral research at The Johns Hopkins University and the University of Wisconsin. Dr. Gilbert is the recipient of several awards, including the first Viktor Hamburger Award for excellence in developmental biology education, the Alexander Kowalevsky Prize for evolutionary developmental biology, honorary degrees from the Universities of Helsinki and Tartu, and the Medal of François I from the Collège de France. He is a Fellow of the American Association for the Advancement of Science, a corresponding member of the St. Petersburg Society of Naturalists, and on the International Advisory Board for the National Institute of Basic Biology in Japan. He has been chair of the Professional Development and Education Committee of the Society for Developmental Biology. His research pursues the developmental genetic mechanisms by which the turtle forms its shell and the mechanisms by which plasticity and symbionts contribute to development.

Michael J. F. Barresi is an Associate Professor at Smith College in the department of Biological Sciences and Program in Neuroscience. Dr. Barresi was a Biology major and Studio Art minor at Merrimack College. After he received his B.A., Dr. Barresi pursued his doctoral research on muscle fiber type development at Wesleyan University in the laboratory of Dr. Stephen Devoto. He completed his postdoctoral fellowship in Dr. Rolf Karlstrom's laboratory at the University of Massachusetts in Amherst, investigating the development of commissure formation in the zebrafish forebrain. At Smith College, Dr. Barresi's laboratory investigates the molecular and cellular mechanisms governing the development of neural stem cells, commissure formation, and neurodevelopmental responses to environmental teratogens. He has been a member of the Professional Development and Education Committee of the Society for Developmental Biology. Dr. Barresi is an innovator in the classroom, pioneering the use of web conferencing, documentary movie making, and active learning pedagogies in Developmental Biology. Since 2005, he has successfully taught course-based research laboratories in Developmental Biology. In connection with his NSF CAREER award, Dr. Barresi created the "Student Scientists" outreach program to help train and inspire primary and secondary education teachers to infuse investigative curriculum in their classrooms. He was the recipient of the 2012 Sherrerd Prize for Distinguished Teaching at Smith College.

Previous Publication Date(s)

June 2013
March 2010
March 2006

Table of Contents

    I. PATTERNS AND PROCESSES OF BECOMING: A FRAMEWORK FOR UNDERSTANDING ANIMAL DEVELOPMENT

    1. Making New Bodies: Mechanisms of Developmental Organization
    "How Are You?" The Questions of Developmental Biology
    The Cycle of Life
    An Example: A Frog's Life
    Comparative Embryology
    An Overview of Early Development
    Keeping Track of Moving Cells: Fate Maps and Cell Lineages
    Evolutionary Embryology
    Medical Embryology and Teratology

    2. Specifying Identity: Mechanisms of Developmental Patterning
    Levels of Commitment
    Autonomous Specification
    Conditional Specification
    Syncytial Specification
    A Rainbow of Cell Identities

    3. Differential Gene Expression: Mechanisms of Cell Differentiation
    Defining Differential Gene Expression
    Quick Primer on the Central Dogma
    Evidence for Genomic Equivalence
    Modulating Access to Genes
    Anatomy of the Gene
    The Gene Regulatory Network: Defining an Individual Cell
    Mechanisms of Differential Gene Transcription
    Differential RNA Processing
    Control of Gene Expression at the Level of Translation
    Posttranslational Regulation of Gene Expression
    The Basic Tools of Developmental Genetics
    Testing Gene Function


    4. Cell-to-Cell Communication: Mechanisms of Morphogenesis
    A Primer on Cell-to-Cell Communication
    Adhesion and Sorting: Juxtacrine Signaling and the Physics of Morphogenesis
    The Extracellular Matrix as a Source of Developmental Signals
    The Epithelial-Mesenchymal Transition
    Cell
    Signaling
    Paracrine Factors: Inducer Molecules
    The Cell Biology of Paracrine Signaling
    Juxtacrine Signaling for Cell Identity


    5. Stem Cells: Their Potential and Their Niches
    The Stem Cell Concept
    Stem Cell Regulation
    Pluripotent Cells in the Embryo
    Adult Stem Cell Niches
    Adult Neural Stem Cell Niche of the V-SVZ
    The Adult Intestinal Stem Cell Niche
    Stem Cells Fueling the Diverse Cell Lineages in Adult Blood
    The Mesenchymal Stem Cell: Supporting a Variety of Adult Tissues
    The Human Model System to Study Development and Disease
    Stem Cells: Hope or Hype?

    II. GAMETOGENESIS AND FERTILIZATION: THE CIRCLE OF SEX

    6. Sex Determination and Gametogenesis
    Chromosomal Sex Determination
    The Mammalian Pattern of Sex
    Determination
    Primary Sex Determination in Mammals
    Secondary Sex Determination in Mammals: Hormonal Regulation of the Sexual Phenotype
    Chromosomal Sex Determination in
    Drosophila
    Environmental Sex Determination
    Mammalian Gametogenesis
    Coda


    7. Fertilization: Beginning a New Organism
    Structure of the Gametes
    External Fertilization in Sea Urchins
    Activation of Egg Metabolism in Sea Urchins
    Fusion of Genetic Material in Sea Urchins
    Internal Fertilization in Mammals
    Coda


    III. EARLY DEVELOPMENT: CLEAVAGE, GASTRULATION, AND AXIS FORMATION

    8. Rapid Specification in Snails and Nematodes
    Developmental Patterns among the Metazoa
    EARLY DEVELOPMENT IN SNAILS
    Cleavage in Snail Embryos
    Gastrulation in
    Snails
    THE NEMATODE
    C. Elegans
    Cleavage and Axis Formation in
    C. elegans
    Gastrulation in C. elegans

    9. The Genetics of Axis Specification in Drosophila
    Early Drosophila Development
    The Genetic Mechanisms Patterning the
    Drosophila Body
    Segmentation and the Anterior-Posterior Body Plan
    Segmentation Genes

    The Homeotic Selector Genes
    Generating the Dorsal-Ventral Axis
    Axes and Organ Primordia: The Cartesian Coordinate Model
    Coda

    10. Sea Urchins and Tunicates: Deuterostome Invertebrates
    Early Development in Sea Urchins
    Sea Urchin Gastrulation
    Early Development in Tunicates

    11. Amphibians and Fish
    EARLY AMPHIBIAN DEVELOPMENT
    Fertilization, Cortical Rotation, and Cleavage
    Amphibian Gastrulation
    Progressive Determination of the Amphibian Axes
    The Work of Hans Spemann and Hilde Mangold
    Molecular Mechanisms of Amphibian Axis Formation
    Regional Specificity of Neural Induction along the Anterior-Posterior Axis
    Specifying the Left-Right Axis
    EARLY ZEBRAFISH DEVELOPMENT
    Cleavage
    Gastrulation and Formation of the Germ Layers

    12. Birds and Mammals
    EARLY DEVELOPMENT IN BIRDS
    Avian Cleavage
    Gastrulation of the Avian Embryo
    Axis Specification and the Avian "Organizer"
    EARLY DEVELOPMENT IN MAMMALS
    Cleavage
    Mammalian Gastrulation
    Mammalian Axis Formation
    Twins
    Coda

    IV. BUILDING WITH ECTODERM: THE VERTEBRATE NERVOUS SYSTEM AND EPIDERMIS

    13. Neural Tube Formation and Patterning
    Transforming the Neural Plate into a Tube: The Birth of the Central Nervous System
    Patterning the Central Nervous System

    All Axes Come Together

    14. Brain Growth
    Neuroanatomy of the Developing Central Nervous System
    Developmental Mechanisms Regulating Brain Growth
    Development of the Human Brain

    15. Neural Crest Cells and Axonic Specificity
    THE NEURAL CREST
    Regionalization of the Neural Crest
    Neural Crest: Multipotent Stem Cells?
    Specification of Neural Crest Cells
    Neural Crest Cell Migration: Epithelial to Mesenchymal and Beyond
    Migration Pathways of Trunk Neural Crest Cells
    Cranial Neural Crest
    The "Chase and Run" Model
    Neural Crest-Derived Head Skeleton
    Cardiac Neural Crest
    ESTABLISHING AXONAL
    PATHWAYS IN THE NERVOUS SYSTEM
    The Growth Cone: Driver and Engine of Axon Pathfinding
    Axon Guidance
    The Intrinsic Navigational Programming of Motor Neurons
    How Did the Axon Cross the Road?
    The Travels of Retinal Ganglion Axons
    Target Selection: "Are We There Yet?"
    Synapse Formation
    A Program of Cell Death

    16. Ectodermal Placodes and the Epidermis
    CRANIAL PLACODES: THE SENSES OF OUR HEADS
    The Dynamics of Optic Development: The Vertebrate Eye
    Formation of the Eye Field: The Beginnings of the Retina
    The Lens-Retina Induction Cascade
    THE EPIDERMIS AND ITS CUTANEOUS APPENDAGES
    Origin of the Epidermis
    The Ectodermal Appendages
    Coda


    V. BUILDING WITH MESODERM AND ENDODERM: ORGANOGENESIS

    17. Paraxial Mesoderm: The Somites and Their Derivatives
    Cell Types of the Somite
    Establishing the Paraxial Mesoderm and Cell Fates Along the Anterior-Posterior Axis
    Somitogenesis

    Sclerotome Development
    Dermomyotome Development
    Osteogenesis: The Development of Bones
    Maturation of Muscle


    18. Intermediate and Lateral Plate Mesoderm: Heart, Blood, and Kidneys
    INTERMEDIATE MESODERM: THE KIDNEY
    Specification of the Intermediate Mesoderm: Pax8 and Lim1
    Reciprocal Interactions of Developing Kidney Tissues
    LATERAL PLATE MESODERM: HEART AND CIRCULATORY SYSTEM
    Heart Development
    Blood Vessel Formation
    Hematopoiesis: Stem Cells and Long-Lived Progenitor Cells
    Coda


    19. Development of the Tetrapod Limb
    Limb Anatomy
    Limb Bud
    Hox
    Gene Specification of Limb Skeleton Identity
    Determining What Kind of Limb to Form and Where to Put It
    Outgrowth: Generating the Proximal-Distal Axis of the Limb

    Specifying the Anterior-Posterior Axis
    Generating the Dorsal-Ventral Axis
    Cell Death and the Formation of Digits and Joints
    Evolution by Altering Limb Signaling Centers

    20. The Endoderm: Tubes and Organs for Digestion and Respiration
    The Pharynx
    The Digestive Tube and Its Derivatives
    The Respiratory Tube

    VI. POSTEMBRYONIC DEVELOPMENT

    21. Metamorphosis: The Hormonal Reactivation of Development
    Amphibian Metamorphosis
    Metamorphosis in Insects
    Metamorphosis of the Pluteus Larva

    22. Regeneration
    Many Ways to Rebuild
    Hydra: Stem Cell-Mediated
    Regeneration, Morphallaxis, and Epimorphosis
    Stem Cell-Mediated Regeneration in Flatworms
    Salamanders: Epimorphic Limb Regeneration
    Luring the Mechanisms of Regeneration from Zebrafish Organs
    Regeneration in Mammals

    23. Aging and Senescence
    Genes and Aging
    Random Epigenetic Drift
    Stem Cells and Aging
    Exceptions to the Aging Rule

    VII. DEVELOPMENT IN WIDER CONTEXTS

    24. Development in Health and Disease: Birth Defects, Endocrine Disruptors, and Cancer
    The Role of Chance
    Genetic Errors of Human Development
    Teratogenesis: Environmental Assaults on Animal Development

    Endocrine Disruptors: The Embryonic Origins of Adult Disease
    Transgenerational Inheritance of Developmental Disorders
    Cancer as a Disease of Development
    Coda

    25. Development and the Environment: Biotic, Abiotic, and Symbiotic Regulation of Development
    The Environment as a Normal Agent in Producing Phenotypes
    Polyphenic Life Cycles
    Developmental Symbioses
    Coda

    26. Development and Evolution: Developmental Mechanisms of Evolutionary Change
    Descent with Modification: Why Animals Are Alike and Different
    Preconditions for Evolution: The Developmental Structure of the Genome
    Deep Homology
    Mechanisms of Evolutionary Change
    Developmental Constraints on Evolution
    Selectable Epigenetic Variation
    Coda

    Glossary
    Author Index
    Subject Index

Teaching Resources

For Students

Companion Website

Significantly enhanced for the eleventh edition, and referenced throughout the textbook, the Developmental Biology Companion Website provides students with a range of engaging resources, in the following categories:

* NEWDev Tutorials: Professionally produced video tutorials, presented by the textbook's authors, reinforces key concepts.

* NEWWatch Development: Putting concepts into action, these informative videos show real-life developmental biology processes.

* Web Topics: These extensive topics provide more information for advanced students, historical, philosophical, and ethical perspectives on issues in developmental biology, and links to additional online resources.

* NEWScientists Speak: In these question-and-answer interviews, developmental biology topics are explored by leading experts in the field.

* Plus thefull bibliography of literature cited in the textbook (most linked to their PubMed citations).

DevBio Laboratory: Vade Mecum3

Included with each new copy of the textbook, Vade Mecum3 is an interactive website that helps students understand the organisms discussed in the course, and prepare them for the lab. The site includes videos of developmental processes and laboratory techniques, and has chapters on the following organisms: slime mold (Dictyostelium discoideum), planarian, sea urchin, fruit fly (Drosophila), chick, and amphibian.

For Instructors

Instructor's Resource Library (available to qualified adopters)

The Developmental Biology, Eleventh Edition, Instructor's Resource Library includes the following resources:

* NEWDeveloping Questions: Answers, references, and recommendations for further reading are provided so that you and your students can explore the Developing Questions that are posed throughout each chapter.

* Textbook Figures & Tables: All of the textbook's figures, photos, and tables are provided both in JPEG (high- and low-resolution) and PowerPoint formats. All images have been optimized for excellent legibility when projected in the classroom.

* Video Collection: Includes video segments depicting a wide range of developmental processes, plus segments from DevBio Laboratory: Vade Mecum3, and Differential Experessions2.

* Vade Mecum3 PowerPoints: Chick serial sections and whole mounts, provided in both labeled and unlabeled versions, for use in creating quizzes, exams, or in-class exercises.

* NEWCase Studies in Dev Bio: This new collection of case study problems accompanies the Dev Tutorials and provides instructors with ready-to-use in-class active learning exercises. The case studies foster deep learning in developmental biology by providing students an opportunity to apply course content to the critical analysis of data, to generate hypotheses, and to solve novel problems in the field. Each case study includes a PowerPoint presentation and a student handout with accompanying questions.

* Developmental Biology: A Guide for Experimental Study, Third Edition, by Mary S. Tyler: The complete lab manual, in PDF format.

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