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Crystal Structure Analysis

A Primer

Third Edition

Jenny Pickworth Glusker and Kenneth N. Trueblood

Publication Date - July 2010

ISBN: 9780199576357

304 pages
9.7 x 7.4 inches

In Stock

Retail Price to Students: $189.99


Crystal Structure Analysis, Third Edition, explains how and why the detailed three-dimensional architecture of molecules can be determined by an analysis of the diffraction patterns obtained when X-rays or neutrons are scattered by the atoms in single crystals. Part 1 covers the nature of the crystalline state, diffraction in general, and diffraction by crystals, and also looks briefly at experimental procedures. Part II examines the problem of converting the experimentally obtained data into a model of the atomic arrangement that scattered these beams. Part III discusses techniques for refining the approximate structure to the degree warranted by the experimental data. It also describes the many types of information that can be obtained by modern crystal structure analysis. The text is enhanced by numerous illustrations, a detailed glossary, and several appendices that cover mathematical details.

About the Author(s)

Jenny Pickworth Glusker is Senior Member Emeritus at the Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA, and Adjunct Professor of Biochemistry and Biophysics at the University of Pennsylvania.

The late Kenneth N. Trueblood taught at UCLA for most of his career. For his profound influence on beginning chemistry students, he received the first UCLA Distinguished Teaching award (1961) and the national award for excellence in teaching given by the Manufacturing Chemists Association in 1978.

Previous Publication Date(s)

July 2010
August 1985
January 1972

Table of Contents

    1. Introduction
    2. Crystals
    3. Diffraction
    4. Experimental Measurements
    5. The Diffraction Pattern Obtained
    6. The Phase Problem
    7. Symmetry and Space Groups
    8. The Derivation of Trial Structures: I. Analytical Methods of Direct Phase Determination
    9. The Derivation of Trial Structures: II. Patterson, Heavy Atom, and Isomorphous Replacement Methods
    10. Anomalous Dispersion and Absolute Configuration
    11. Refinement of the Trial Structure
    12. Structural Parameters: Analysis of Results
    13. Micro- and Noncrystalline Structures
    14. Outline of a Crystal Structure Determination

Related Title

Principles of X-ray Crystallography