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Bioorganic Chemistry: Peptides and Proteins

Edited by Sidney M. Hecht

Publication Date - 19 March 1998

ISBN: 9780195084689

544 pages
6-1/2 x 9-1/4 inches


Bioorganic chemistry has expanded rapidly over the past two decades, enriching the disciplines of biology and chemistry and providing important insights into the workings of biological systems at a molecular level. Recently, this growing field has witnessed some very exciting results in applying design and synthesis techniques to many problems in molecular biology. Bridging the gap between chemistry and biology, Topics in Bioorganic and Biological Chemistry: A Series of Books in Support of Teaching and Research will serve the needs of the many graduate students and researchers who work in and study this discipline.
This second volume, Bioorganic Chemistry: Peptides and Proteins, provides a broad overview of the topic. It covers the chemical synthesis of peptides and proteins and modern methods for analysis of protein structure and folding, reviews the ways in which proteins function as catalysts, and compares enzymes with antibody catalysts. The text is comprised of 14 chapters, making it ideal for use in a one-semester, graduate level special topic course in peptides and proteins.
Each chapter begins with an introduction that includes basic principles, a summary of key findings which support current research in the field, and an overview of current research activity. The remainder of each chapter deals in greater detail with a number of recent studies that illustrate the nature of ongoing activity in the field. All chapters have been written by leading researchers, and numerous references are given. Topics in Bioorganic and Biological Chemistry is the first series specifically designed to facilitate the education of graduate students and postdoctoral researchers. The first three volumes in the series, Bioorganic Chemistry: Nucleic Acids, Peptides and Proteins, and Carbohydrates, will also prove helpful to research workers who wish to gain familiarity with specific research topics.

Table of Contents

    1. Introduction to Peptides and Proteins, Milton J. Axley
    2. Chemical Synthesis of Peptides, Victor Hruby and Jean-Philippe Meyer
    3. Total Chemical Synthesis of Proteins, Michael C. Fitzgerald and Stephen B.H. Kent
    4. Structural Analysis of Proteins, John E. Shively
    5. Protein Structure, Charles W. Carter. Jr.
    6. Protein Folding, Zhi-Ping Liu, Josep Rizo, and Lila M. Gierasch
    7. Nucleic Acid Interactive Protein Domains That Require Zinc, Michael A. Massiah, Paul R. Blake, and Michael F. Summers
    8. Understanding the Mechanisms and Rates of Enzyme-Catalyzed Proton Transfer Reactions to and from Carbon, John A. Gerlt
    9. Site-Directed Mutagenesis, Paul J. Loida, Ronald A. Hernan, and Stephen G. Sligar
    10. The Structural Basis of Antibody Catalysis, Donald Hilvert, Gavin MacBeath, and Jumi A. Shin
    11. Peptide Hormones, Arno F. Spatola
    12. Peptide Mimetics, Hiroshi Nakanishi and Michael Kahn
    13. Use of Enzymes in Organic Synthesis, Zhen Yang and Alan J. Russell
    14. Engineered Proteins in Materials Research, David A. Tirrell, Jane G. Tirrell, Thomas L. Mason, and Maurille J. Fournier

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