We use cookies to enhance your experience on our website. By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time. Find out more

Bioorganic Chemistry: Nucleic Acids

Edited by Sidney M. Hecht

Publication Date - April 1996

ISBN: 9780195084672

512 pages
6-1/2 x 9-1/4 inches


Bioorganic chemistry has expanded rapidly over the past two decades, enriching the disciplines of biology and chemistry and providing important insights into the workings of biological systems at a molecular level. Recently, this growing field has witnessed some very exciting results in applying design and synthesis techniques to many problems in molecular biology. Much of the current work in areas such as protein folding, signal transduction, molecular recognition, monoclonal antibodies, and drug design is being conducted by bioorganic chemists. Bridging the gap between chemistry and biology, Topics in Bioorganic and Biological Chemistry, A Series of Books in Support of Teaching and Research is a novel resource designed to serve the needs of the many graduate students, professionals, and researchers who work and study in these fields by concisely summarizing a range of topics which constitute the core of expertise in this emerging discipline.
This first volume, Bioorganic Chemistry: Nucleic Acids provides an overview of DNA and RNA, including coverage of biosynthesis, structure, and their functions in information storage and transmission. Special emphasis is given to the manner in which the individual chemistries of DNA and RNA conduce to their specific functions. The chemistry of molecules that disrupt nucleic acid biosynthesis and functions, antisense technologies involving RNA and DNA, and naturally occurring ribozymes are also covered. Each chapter begins with an introduction that includes basic principles, a summary of key findings which support current research in the field, and an overview of current research activity. The remainder of each chapter deals in greater detail with a number of recent studies that illustrate the nature of ongoing activity in the field.
Edited by one of the world's top researchers and featuring contributions from accomplished researchers, Bioorganic Chemistry is a state of the art, accessible account of the subject area which offers readers insights into the most current directions of research and important applications. Bioorganic Chemistry comprises three volumes: Nucleic Acids; Peptides and Proteins; and Carbohydrates.

Table of Contents

    List of Contributors
    1. Fundamentals of Nucleic Acids, Eric C. Long
    2. The Chemical Synthesis of DNA/RNA, Serge L. Beaucage and Marvin H. Caruthers
    3. Enzymatic Methods for the Preparation and Manipulation of Nucleic Acids, Mark Van Cleve
    4. Structure of DNA and RNA, M. Sriram and Andrew H.J. Wang
    5. Chemical Mapping of Nucleic Acid Conformation, Thomas D. Tullius
    6. Introduction to H NMR Spectroscopy of DNA, Kenneth J. Addess and Juli Feigon
    7. The Formation of Alternative Structures in DNA, David M. J. Lilley
    8. Reporter Groups for the Analysis of Nucleic Acid Structure, Maryanne J. O'Donnell and Larry W. McLaughlin
    9. Nucleic Acid Binding and Catalysis by Metal Ions, Sergei A. Kazakov
    10. Small Molecule-DNA Interaction, John A. Mountzouris and Laurence H. Hurley
    11. The Chemistry of Protein-DNA Interactions, Christopher J. Larson and Gregory L. Verdine
    12. Antisense/Antigene Oligonucleotides, Paul S. Miller
    13. Catalytic RNA, Francis J. Schmidt
    14. The Polymerase Chain Reaction and In Vitro Random Selection, Reuel B. Van Atta and Sam J. Rose

Related Titles