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Biomolecular NMR Spectroscopy

Jeremy N. S. Evans

Publication Date - 28 September 1995

ISBN: 9780198547662

464 pages


The technique of nuclear magnetic resonance (NMR) spectroscopy is an important tool in biochemistry and biophysics for the understanding of the structure and, ultimately, the function of biomolecules. This textbook explains the salient features of biological NMR spectroscopy to undergraduates and postgraduates taking courses in NMR, 4iological NMR, physical biochemistry, and biophysics. Unlike other books in the general field of NMR (except the advanced treatises), the approach here is to introduce and make use of quantum mechanical product operators as well as the classical vector method of explaining the bewildering array of pulse sequences available today. The book covers two-dimensional, three-dimensional, and four-dimensional NMR, and their application to protein and DNA structure determination. A unique feature is the coverage of the biological aspects of solid-state NMR spectroscopy. The author provides many selected examples from the research literature, illustrating the applications of NMR spectroscopy to biological proteins.


"This book should be considered seriously for any course dealing with biomolecular NMR spectroscopy."--Microchemical Journal

"An instructor of an NMR course in a Biochemistry department would surely be pleased with the array of biochemical NMR examples presented .... In addition, a biologically oriented student would find Evans useful as a resource to determine if NMR could be used to provide data for a particular biochemical problem." -- Nature Structural Biology

"Overall, Biomolecular NMR Spectroscopy is a very useful book .... students received the text very well and were favorably impressed with the coverage." -- Biophysical Journal

"A worthwhile introduction to the field."--Journal of Magnetic Resonance

"A lucid teaching text...A very worthwhile purchase for anyone who wishes to gain a better understanding of the powers and limitations of NMR spectroscopy as a tool for the study of biologic processes...Written in a good-natured conversational style...The section on theory contains particularly clear and succinct explanations of key ideas...A valuable feature of this book is the attention given to practical considerations...The paper and printing are of good quality. Many of the excellent graphs, illustrations, and NMR spectra are reproduced from key reference cited in the book...An excellent teaching text for students...a valuable reference..."--Radiology

Table of Contents

    Part 1: Theory
    1. Introduction
    2. Methods for spectral assignment - multidimensional NMR
    3. Obtaining NMR structures
    Part II: Proteins
    4. Protein structure
    5. Protein folding
    Part III: Enzymes
    6. Enzyme function
    7. Acyl and phosphoryl transfer enzymes
    8. Other enzymes
    Part IV: Nucleic Acids and Carbohydrates
    9. Nucleic acids and carbohydrates
    Part V: Membranes
    10. Structure of membranes and membrane proteins
    Appendix 1 Examples of product operator calculations
    Appendix 2 Useful NMR data on amino acid residues
    Appendix 3 Useful NMR data on oligonucleotide residues
    Appendix 4 Useful NMR data on common solvents

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