We use cookies to enhance your experience on our website. By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time. Find out more
Instructor inspection copy request
Cover

Bioinorganic Chemistry

Dieter Rehder

Publication Date - 27 February 2014

ISBN: 9780199655199

240 pages
Paperback
9.7 x 7.4 inches

Description

Bioinorganic chemistry lies at the interface of inorganic chemistry and biochemistry, and explores the function of inorganic species in living systems - from the iron that helps our red blood cells transport oxygen to our tissues, to the calcium that forms an integral part of our bones.

In their book, Rehder and Nordlander provide a broad overview of this dynamic field, reviewing the key chemical elements that have important biological function, and exploring how the chemistry of these elements is central to the function of biological systems.

With sidebars that both review underlying principles of importance to the subject - including the concepts of magnetism and chirality - and discuss some of the analytical approaches that have enabled us to elucidate the biological role of the chemical elements, Bioinorganic Chemistry is the ideal resource for those discovering the field for the first team, and who need a clear, balanced account of the subject.

Online Resource Centre
The Online Resource Centre to accompany Bioinorganic Chemistry features figures from the book in electronic format, for use in lecture slides and other teaching materials.

Features

  • A truly student-friendly account of this buoyant area of chemistry
  • Broad, balanced coverage makes it the perfect resource for those encountering the field for the first time
  • Places particular emphasis on the biological function of the chemical elements, unifying the fields of chemistry and biology in a coherent way
  • Sidebars discuss the analytical approaches adopted to study bioinorganic systems, helping readers to appreciate the experimental basis of the subject
  • An Online Resource Centre provides additional teaching materials for lecturers

About the Author(s)

Dieter Rehder is Professor at the Institute of Inorganic and Applied Chemistry, University of Hamburg. He was winner of the Vanadis Award 2006 for outstanding research in the field of vanadium chemistry.

Table of Contents

    Introduction
    1. Bio-Elements in the Periodic Table
    2. Pre-Life and Early Life Forms, and Extremophiles
    3. The Alkaline and Alkaline Earth Metals
    3.1. Overview
    3.2. Ion Channels and Ion Transport
    3.3. Sodium and Potassium
    3.4. Magnesium
    3.5. Calcium
    3.5.1. Calcium Ions as second messenger
    3.5.2. Calcium Ions as second messenger
    3.5.3. Mineralized calcium
    4. Mineralized calcium
    4.1. General, and Aqueous Chemistry
    4.2. Mobilization, Transport, Storage, Delivery, and Mineralization of Iron
    5. Electron Transport by Iron Proteins, and the Reduction of Oxygen
    5.1. Overview
    5.2. The mitochondrial respiratory chain
    5.3. The mitochondrial respiratory chain
    6. Classification of Copper Proteins (Overview)
    7. Oxygen Transport and Storage
    7.1. Oxygen species
    7.2. Oxygen transport (and storage) proteins Myoglobin and hemoglobin
    8. Oxygenases, Oxidoreductases, Peroxidases and Dismutases
    8.1. Overview and Definitions
    8.2. Cytochrome P450
    8.3. Copper-Based O2-Metabolizing Enzymes
    8.3.1. Tyrosinase and catechol oxidase
    8.3.2. Cu,Zn-Superoxidedismutase
    8.3.3. Galactoseoxidase
    8.4. Iron-Based Oxygenases
    8.5. Oxo-Transfer Proteins Based on Molybdenum, Tungsten and Vanadium
    8.5.1. Molybdo- and tungstopterins
    8.5.2. Vanadate-dependent peroxidases
    9. The Sulfur Cycle
    10. The Nitrogen Cycle
    10.1. Overview, and Native Nitrogenase
    10.2. Overview, and Native Nitrogenase
    10.3. Denitrification
    10.4. Nitric Oxide
    11. Methanogenesis and Nickel Enzymes; Methanotropism
    11.1. Methanogenesis
    11.2. Methanotropism
    11.3. Methanotropism
    .3.1. Ureases
    11.3.2. Nickel Containing Hydrogenases
    11.3.3. Acetylcoenzyme-A Synthase
    11.3.4. Acetylcoenzyme-A Synthase
    12. Photosynthesis
    12.1. Overview
    12.2. The Light Reaction
    12.2.1. Chlorophylls and the water oxidase (Oxygen Evolving Centre, OEC)
    12.2.2. Chlorophylls and the water oxidase (Oxygen Evolving Centre, OEC)
    12.3. The Electron Transfer Chain and the Dark Reaction
    12.4. Artificial Photosynthesis
    13. The Biochemistry of Zinc
    13.1. General and overview
    13.2. Enzymes
    13.2.1. Ligases and synthases
    13.2.2. Carboanhydrases based on Zn or Cd
    13.2.3. Hydrolases
    13.2.4. Alcoholdehydrogenase
    13.3. Structural Functions
    13.3.1. Structural Functions
    13.3.2. Transcription factors (zinc fingers)
    13.3.3. The Ada repair protein
    13.3.4. Thioneins and Cd/Hg detoxification
    14. The Biogenic Metalloid- and Metal-Carbon Bond
    14.1. Vitamin B12
    14.2. Others
    15. Inorganics in Medicine
    15.1. Toxic Metals and Metaloids
    15.2. Dysfunctions Based on Metal Imbalances
    15.2.1. Iron overload and iron deficiency
    15.2.2. Copper and iron the Alzheimer disease
    15.2.3. Zinc antagonists: Cadmium and mercury poisoning
    15.3. Carcinogenic Metal and Metalloid Compounds
    15.4. Metals in Therapy
    15.4.1. Anti-cancer agents
    15.4.2. Treatment of arthritis with gold preparations
    15.4.3. Silver and disinfection
    15.4.4. Lithium treatments (dipolar disorder, hypertension)
    15.4.5. The potential of vanadium and zinc complexes in the treatment of diabetes
    15.4.6. Gastritis and bismuth preparations
    15.4.7. Historical applications
    15.5. Metals in Diagnostics
    15.6. Metals in Implants
    15.7. The Therapeutic and Toxic Potentials of CO, NO, H2S and NO3-
    15.8. Metal-Functionalized Nucleic Acids

Related Titles