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An Introduction to Medicinal Chemistry

Sixth Edition

Graham Patrick

Publication Date - June 2017

ISBN: 9780198749691

832 pages
10.4 x 7.7 inches

In Stock

Retail Price to Students: $64.95

Renowned for its clear and accessible writing style, An Introduction to Medicinal Chemistry 6th edition is widely regarded as the leading undergraduate text in this area. Complete coverage of the subject is augmented by extensive pedagogical support and opportunities for students to hone their problem solving skills


For many people, taking some form of medication is part of everyday life, whether for mild or severe illness, acute or chronic disease, to target infection or to relieve pain. However for most it remains a mystery as to what happens once the drug has been taken into the body: how do the drugs actually work? Furthermore, by what processes are new drugs discovered and brought to market?

An Introduction to Medicinal Chemistry, sixth edition, provides an accessible and comprehensive account of this fascinating multidisciplinary field. Assuming little prior knowledge, the text is ideal for those studying the subject for the first time. Part one of the book introduces the principles of drug action via targets such as receptors and enzymes. The book goes on to explore how drugs work at the molecular level (pharmacodynamics), and the processes involved in ensuring a drug meets its target (pharmacokinetics). Further sections cover the processes by which drugs are discovered and designed, and what has to happen before a drug can be made available to the public. The book concludes with a selection of current topics in medicinal chemistry, and a discussion of various key drug groups. The subject is brought to life throughout by engaging case studies highlighting particular drugs and the stories behind their discovery and development.

The Online Resource Centre features:

For students:
DT Multiple Choice Questions to support self-directed learning
DT Web articles describing recent developments in the field and further information on topics covered in the book
DT Journal Club to encourage students to critically analyse the research literature
DT Molecular Modelling Exercises, with new exercises in Chem3D
DT New assignments to help students develop data analysis and problem solving skills

For registered adopters of the book:

DT A test bank of additional multiple-choice questions, with links to relevant sections in the book
DT Answers to end-of-chapter questions.
DT Figures from the book, ready to download.
DT Power Point slides to accompany every chapter in the book.


  • Much-praised writing style makes the text ideal for those new to the subject
  • Frequent boxes and case studies help students to link the underlying theory to its pharmaceutical application
  • Numerous questions and activities both throughout the book and on the accompanying website help students hone their problem solving skills
  • Well-developed pedagogy--including frequent key point sections, a full glossary of terms, and links to material on the accompanying Online Resource Centre--supports students in their learning

About the Author(s)

Graham Patrick is Lecturer in Organic Chemistry and Medicinal Chemistry at the University of the West of Scotland.

Dr. Graham Patrick gained his BSc Honours at Glasgow University, winning the McKay-Smith Prize for Chemistry. He completed his PhD with Professor Kirby and Professor Robins studying the biosynthesis of gliotoxin and related fungal metabolites. Following this, he worked in the pharmaceutical industry as a research chemist and radiochemist on a variety of projects that included topic areas such as opioids, antibacterial agents and antidepressants.

His academic career has included positions at Leeds and Strathclyde Universities as well as the Australian National University. He joined the University of Paisley (now the University of the West of Scotland) in 1990, teaching medicinal chemistry and drug design.

Table of Contents

    1. Drugs and drug targets - an overview
    Part A Drug targets - structure and function
    2. Protein structure and function
    3. Enzymes: structure and function
    4. Receptors: structure and function
    5. Receptors and signal transduction
    6. Nucleic acids: structure and function
    Part B Pharmacodynamics and pharmacokinetics
    7. Enzymes as drug targets
    8. Receptors as drug targets
    9. Nucleic acids as drug targets
    10. Miscellaneous drug targets
    11. Pharmacokinetics and related topics
    Case study 1: Statins
    Part C Drug discovery, design, and development
    12. Drug discovery: finding a lead
    13. Drug design: optimizing target interactions
    14. Drug design: optimizing access to the target
    15. Getting the drug to market
    Case study 2: The design of ACE inhibitors
    Case study 3: Artemisinin and related antimalarial drugs
    Case study 4: The design of oxamniquine
    Part D Tools of the trade
    16. Combinatorial synthesis
    17. Computers in medicinal chemistry
    18. Quantitative structure-activity relationships (QSAR)
    Case study 5: De novo design of a thymidylate synthase inhibitor
    Part E Selected topics in medicinal chemistry
    19. Antibacterial agents
    20. Antiviral agents
    21. Anticancer agents
    22. Cholinergics, anticholinergics, and anticholinesterases
    23. Drugs acting on the adrenergic nervous system
    24. Opioid analgesics
    25. Antiulcer agents
    26. Cardiovascular drugs
    Case study 6: Steroidal anti-inflammatory agents
    Case Study 7: Design of a novel antidepressant
    Case Study 8: The design and development of aliskiren
    Case Study 9: Factor Xa inhibitors
    Case Study 10: Reversible inhibitors of HCV NS3-4A protease

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