Molecular Biology of Cancer

Description

Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an accessible, engaging, and optimistic account of cancer biology for undergraduate and graduate students.

• Provides an engaging and manageable route into the complex subject of cancer biology
• Describes the theoretical basis of cancer biology and shows how this theory is applied to develop new cancer therapies, giving students a clear appreciation of how theoretical knowledge can be translated into therapeutic strategies
• Draws on the latest research in this dynamic field but presents it in a manner readily accessible to the student
• Available for students and institutions to purchase in a variety of formats, and is supported by online resources.

New to this edition

• The inclusion of additional primary data from the literature provides up-to-date information about this dynamic field of research.
• Figures to illustrate mechanisms of DNA repair.
• New topics covered include extrachromosomal circular DNA as major sources of oncogene expression and tumor heterogeneity, the use of errors in RNA transcription and splicing as a new source of neoantigens for vaccines, the application of artificial intelligence to cancer imaging, and expanded applications of CRISPR, to name a few.
• The expanded "Pioneers in the field" feature introduces students to thirteen inspiring molecular biologists working in the field from past to present.

About the Author(s)

Lauren Pecorino, Professor, Cancer Biology, University of Greenwich

Dr Lauren Pecorino obtained her PhD in Cell and Developmental Biology at the State University of New York at Stony Brook, USA. She then moved to London to carry out a post-doctoral tenure at the Ludwig Institute for Cancer Research where she studied the phenomenon of limb regeneration. Here she used a technique called biolistics, using a 'gene gun' to shoot gold bullets coated with DNA to introduce genes into the regenerating limbs of live newts. Since 1996, Lauren has been a member of academic staff at the University of Greenwich, where she developed her interest in teaching Cancer Biology. In 2018, Lauren was made a Principal Fellow of the Higher Education Academy.

Table of Contents

1:Introduction
2:The cancer genome
3:Regulation of gene expression
4:Growth factor signaling and oncogenes
5:The cell cycle
6:Tumor suppressor genes
7:Apoptosis
8:Cancer stem cells and the regulation of self-renewal and differentiation pathways: focus on colon cancer and leukemias
9:Metastasis
10:Angiogenesis
11:Reprogrammed metabolism and diet
12:Tumor immunology and immunotherapy
13:Inflammation, infection, and the microbiome
14:Strategies and tools for research and drug development

Reviews

"I think this is a very well written book, the features are clear and concise and it's very easy and pleasing to follow and understand. It's covered a wide range of topics and the figures/diagrams are excellent. The features such as pause and think and pioneers in the field are such a great touch." - Blyth Richards, Student, Swansea University

"This textbook has extensive learning features that help to improve the reader's user experience and knowledge of scientific concepts. It is extremely well detailed and concise with a clear structure throughout. Specialised when needed, simplified whenever possible, highly recommend." - Daniel O'Neill, Student, Aberystwyth University

"This textbook is a clear and comprehensive overview of molecular biology in the context of cancer research and treatment. It is accessible to undergraduates and a helpful refresher for postgraduates as well." - Holly English, Student, University College Dublin

"I loved this book! It is stimulating and makes some very challenging work readable and accessible. The various learning features are useful and supportive, and serve to encourage a [strong] level of engagement." - Gary Edward Spencer, Student, Canterbury Christ Church University

"Overall I feel that the way in which the book explains complex mechanisms is outstanding. Where other textbooks can often leave you feeling perplexed, this textbook simplifies everything into manageable chunks." - Rebecca Kemp, Student, University of Nottingham

"This book provides a comprehensive grounding for students who want to investigate cancer mechanisms. It contains helpful active learning activities to ensure that students can understand, and most importantly, apply their knowledge to real life scenarios." - Dr Sarah Bailey, University of Surrey

"A good overview of the current understanding of the molecular events in cancer biology and how they are being exploited for targeting cancer treatments at the molecular level." - Dr Christopher Mee, University of Leicester

Additional Resources

Molecular Biology of Cancer is supported by online resources and is available for students and institutions to purchase in a variety of formats.

The ebook offers a mobile experience and convenient access along with functionality tools, navigation features, and links that offer extra learning support: www.oxfordtextbooks.co.uk/ebooks

The online resources include:
For students:
- Multiple choice questions
- Web links to additional cancer biology resources

For registered adopters of the book:
· Figures from the book, available to download