Mass Spectrometry

Description

The most clear, concise, and accessible first introduction to the basic principles of mass spectrometry.

• Focused introductions designed to give students an in-depth understanding of a diverse range of important topics in modern chemistry
• Frequent diagrams, margin notes, and definitions support students in their learning
• Questions at the end of every chapter and interactive online questions encourage active learning and promote deep understanding
• Provides a clear and accessible first introduction to the basic principles of mass spectrometry
• Reflects the practical elements of mass spectrometry which are an increasingly important focus of undergraduate studies
• Includes mathematical content tailored to the specific needs and abilities of an undergraduate audience
• Supplemented by numerous real-life examples, interesting facts about the technique, and links to other textbooks which provide more detailed coverage

About the Author(s)

James McCullagh, Associate Professor of Analytical Chemistry, University of Oxford, and Neil Oldham, Professor of Biomolecular Mass Spectrometry, University of Nottingham

Professor James McCullagh is a lecturer in Analytical Chemistry at the University of Oxford and Director of the Mass Spectrometry Research Facility in the Department of Chemistry. He spent several years in industry before moving to academia where he now conducts research developing novel mass spectrometry and separation science techniques and applies these at the interfaces between chemistry, biology and medicine. In his early career he used mass spectrometry to investigate diet and nutrition and developed methods for compound-specific radiocarbon dating. In the last ten years his research has focussed on understanding the role of small molecules in health and disease and developing metabolomics and isotope tracer techniques. Current interests focus on measuring central energy metabolism and understanding its perturbations in diseases including diabetes and cancer. He is the author of over 80 research papers and books.

Professor Neil Oldham is Professor of Biomolecular Mass Spectrometry in the School of Chemistry at the University of Nottingham. His research activities are focussed on the use of mass spectrometry and associated techniques for the study of protein structure, interactions and modification, although he also has considerable experience in small molecule mass spectrometry and natural product analysis. He has authored over 130 research papers in the field of applied mass spectrometry. His teaching interests span organic and biological chemistry, organic spectroscopy and analytical chemistry.

Table of Contents

1:Introduction
2:Methods of ionization
3:Methods of mass analysis
4:Resolution, accurate mass and sensitivity
5:Tandem mass spectrometry
6:Interpretation of mass spectra
7:Separation techniques and quantification
8:Mass spectrometry applications

Reviews

"Mass Spectrometry is now an essential tool in a wide range of scientific disciplines across academia and industry. This superb book provides a highly accessible and up to date introduction for students and researchers alike. I highly recommend it." - Professor Dame Carol Robinson, University of Oxford and President of the Royal Society of Chemistry.

"A well written and complete overview of the subject." - Karin Heutinck, Saxion University of Applied Sciences, Netherlands

"Excellent support material pitched at an appropriate level to take students through their degree programme and beyond. " - Cate Cropper, University of Liverpool

"Concise and clear - the book is built up systematically going from instrumentation to interpretation to applications. " - Hanno Kossen, Newcastle University

"The descriptions are really amenable to the undergraduate student, and are balanced very well between simplicity with sufficient detail." - Peter Fielden, Lancaster University

Additional Resources

Online resources

The online resources that accompany Mass Spectrometry include:

For students:
- Multiple-choice questions for self-directed learning

For registered adopters of the text:

- Figures from the book available to download