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Introduction to Bioinformatics

Fifth Edition

Arthur Lesk

21 May 2019

ISBN: 9780198794141

432 pages

In Stock

Price: £44.99

Active, accessible, and assuming no prior knowledge: the ideal text for biologists encountering bioinformatics for the first time.



Active, accessible, and assuming no prior knowledge: the ideal text for biologists encountering bioinformatics for the first time.

  • Aimed at a biological audience, it is ideal for those without detailed prior knowledge of programming who are encountering bioinformatics for the first time
  • Frequent examples, self-test questions, problems, and exercises are incorporated throughout the text to encourage self-directed learning
  • Emphasises the practical applications of the subject to a wide range of disciplines, such as molecular biology, medicine, forensic science and anthropology
  • Invaluable information retrieval techniques and data calculations are covered to enable the reader to carry out their own online research
  • Online resources include data sets and Web-based problems, alongside guidance for answering the problems and exercises in the book

New to this edition

  • A host of new material includes new content on next generation sequencing, function prediction, sequence assembly, epigenomics, the bioinformatics of gene editing, and the effects of single nucleotide variants
  • Greater background information has been provided for advanced topics to ensure that a broad range of readers will have the necessary pre-requisite knowledge to understand them

About the Author(s)

Arthur Lesk, Professor of Biochemistry and Molecular Biology, The Pennsylvania State University, USA

Table of Contents

    2:From genetics to genomes
    3:The panorama of life
    4:Alignments and phylogenetic trees
    5:Structural bioinformatics and drug discovery
    6:Scientific publications and archives: media, content, access, and presentation
    7:Artificial intelligence and machine learning
    8:Introduction to systems biology
    9:Metabolic pathways
    10:Control of organization and organization of control


"This is an excellent textbook that would appeal to those new to the field as well as those who have prior experience in the subject area. The mixture of narrative and clear diagrammatic representation has been skilfully woven together to produce a rich contextualised resource." - Dr Don Green, London Metropolitan University

"It provides an excellent introduction to the subject and balances a historical perspective with recent developments. Although it is easily accessible, in places it doesn't shy away from more complex, but relevant computational analysis." - Dr Colin Sharpe, University of Portsmouth

"[It] discusses the key concepts well and in an easy to understand format, with useful exercises and examples of real-world applications." - Dr Dallas Roulston, Middlesex University London

"The writing style is appropriate, consistent and very clear." - Dr. Lorena Fernández-Martínez, Edge Hill University

"My "go to" introductory text on bioinformatics. Accessible, yet intelligent." - Dr Lee J. Byrne, Canterbury Christ Church University

Additional Resources

Digital formats and resources

Introduction to Bioinformatics is supported by online resources and is available for students and institutions to purchase in a variety of formats.

The e-book offers a mobile experience and convenient access along with functionality tools, navigation features and links that offer extra learning support: www.oxfordtextbooks.co.uk/ebooks

Access to the online resources is free of charge. Resources include:

For lecturers (password protected):
- Figures and tables from the book available to download

For students:
- 'Weblems'- web related problems
- Data from the book in computer-readable form
- Guidance to help students answer problems from the text, and answers to end of chapter exercises

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