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Drug Design and Development

Chris Rostron

August 2020

ISBN: 9780198749318

376 pages
Paperback
246x189mm

In Stock

Price: £32.99

Drug Design and Development outlines the processes involved in the design and development of new drugs and emphasises the significance of these processes to the practice of pharmacy.

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Description

Drug Design and Development outlines the processes involved in the design and development of new drugs and emphasises the significance of these processes to the practice of pharmacy.

  • Presents the full life process of a drug, from the initial design to entry into the market, as a single complex process
  • Explains the need for all practicing pharmacists, including those working in hospitals and high street stores, to understand the processes involved in designing and developing the drugs currently on the market and highlights the relevance to these professions throughout
  • Clearly demonstrates connections between scientific concepts and principles and how they are applied to pharmacy
  • Also available as an e-book with functionality, navigation features, and links that offer extra learning support

About the Author(s)

Chris Rostron, Honorary Research Fellow in the School of Pharmacy and Biomolecular Sciences at Liverpool John Moores University, Chairman of the Academic Pharmacy Forum and Deputy Chair of the Educational Expert Advisory Panel, Royal Pharmaceutical Society

Dr Chris Rostron graduated in Pharmacy from Manchester University and completed a PhD in Medicinal Chemistry at Aston University. He gained Chartered Chemist status in 1975. After a period of post-doctoral research he was appointed as a lecturer in Medicinal Chemistry at Liverpool Polytechnic. He is now an Honorary Research Fellow in the School of Pharmacy and Biomolecular Sciences at Liverpool John Moores University. He was a member of the Academic Pharmacy Group Committee of the Royal Pharmaceutical Society of Great Britain and chairman for the past 5 years. He is currently chairman of the Academic Pharmacy Forum and deputy chair of the Education Expert Advisory Panel of the Royal Pharmaceutical Society. He is an external examiner in Medicinal Chemistry at a number of Schools of Pharmacy both in the UK and abroad. In 2008 he was awarded honorary membership of the Royal Pharmaceutical Society of Great Britain for services to Pharmacy education.

Table of Contents

    1:Introduction
    Part 1 Drug targets
    2:Receptors and signal transduction
    3:Enzymes as drug targets
    4:Nucleic acids and protein synthesis as drug targets
    5:Other drug targets
    Part 2 Origins of drug molecules
    6:Sources of lead compounds
    7:Drug synthesis
    8:Optimisation of lead compounds
    9:Computer-aided drug design
    10:Combinatorial chemistry and high-throughput screening
    11:Biotechnology and biopharmaceuticals
    Part 3 Biological aspects of drug development
    12:Drug metabolism
    13:Pharmacogenetics and pharmacogenomics
    14:Toxicity testing
    Part 4 Preformulation studies
    15:Solubility and drug development
    16:Solid state characteristics
    17:Drug stability
    Part 5 Clinical research
    18:Clinical research and its regulation
    19:Design and management of clinical trials

Reviews

"Well written text that guides students through the complex elements of the drug development process. It has a chemistry focus and utilises 'key points' to reinforce the important aspects at regular opportunities." - Dr James F. Brown, University of Portsmouth

Additional Resources

Digital formats and resources

Drug Design and Development is available for students and institutions to purchase in a variety of formats.

The e-book offers a mobile experience and convenient access along with functionality tools, navigation features, and links that offer extra learning support: www.oxfordtextbooks.co.uk/ebooks