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Bioinorganic Chemistry

Dieter Rehder

January 2014

ISBN: 9780199655199

240 pages
Paperback
246x189mm

In Stock

Price: £38.99

A truly student-friendly account of this buoyant area of chemistry.

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Description

Bioinorganic Chemistry provides a broad overview of this dynamic field, reviewing the key chemical elements that have important biological function, and exploring how the chemistry of these elements is central to the function of biological systems.

  • A truly student-friendly account of this buoyant area of chemistry
  • Broad, balanced coverage makes it the perfect resource for those encountering the field for the first time, and for those who wish to deepen and to broaden their expertise
  • Places particular emphasis on the biological function of the chemical elements, unifying the fields of chemistry and biology in a coherent way
  • Sidebars discuss the analytical approaches adopted to study bioinorganic systems, helping readers to appreciate the experimental basis of the subject
  • An Online Resource Centre provides additional teaching materials for lecturers

About the Author(s)

Dieter Rehder, University of Hamburg, Germany

Dieter Rehder is a Professor in the Institute of Inorganic and Applied Chemistry, University of Hamburg where his main fields of research include organometallic, bioinorganic and medicinal chemistry (of vanadium), oxido- and sulfidometal clusters, and metal NMR. Dieter was winner of the Vanadis Award 2006 for outstanding research in the field of vanadium chemistry.

Table of Contents

    Introduction
    1: Bio-Elements in the Periodic Table
    2: Pre-Life and Early Life Forms; extremophiles
    3: The Alkaline and Alkaline Earth Metals
    3.1: Overview
    3.2: Ion Channels
    3.3: Sodium and Potassium
    3.4: Magnesium
    3.5: Calcium
    4: Iron: General Features of its Inorganic Chemistry and Biochemistry
    4.1: General, and Aqueous Chemistry
    4.2: Mobilization, Transport, Delivery, and Mineralization of Iron
    5: Oxygen Transport and the Respiratory Chain
    5.1: Oxygen and oxygen transport by haemoglobin and myoglobin
    5.2: Oxygen transport by hemerythrin and haemocyanin
    5.3: The Respiratory Chain
    6: Oxidoreductases Based on Iron, Manganese, and Copper
    6.1: Ribonucleotide Reductases
    6.2: Superoxide dismutases, superoxide Reductases, and peroxidases
    6.3: Oxygenases and oxidases
    7: Oxo-transfer Proteins Based on Molybdenum, Tungsten, and Vanadium
    7.1: Molybdo- and Tungsto-pyranopterins
    7.1.1: The Xanthine Oxidase Family
    7.1.2: The Sulfite Oxidase Family
    7.1.3: The Dimethylsulfoxide (DMSO) Reductase Family
    7.2: Vanadate-dependent Haloperoxidases
    7.3: Model Chemistry
    8: The Sulfur Cycle
    8.1: Environmental Sulfur Cycling
    8.2: Biogenic Metabolism of Sulfur
    9: Nitrogenase and Nitrogen Cycle Enzymes
    9.1: Overview and Native Nitrogenase
    9.2: Nitrogenase Models and Model Reactions
    9.3: Denitrification
    9.4: Nitric Oxide
    10: The Methane Cycle and Nickel Enzymes
    10.1: Introduction
    10.2: Methanogenesis
    10.3: Biogenic Oxidation of Methane
    10.4: Nickel Enzymes not Involved in Methane Metabolism
    11: Photosynthesis
    11.1: Overview
    11.2: The Reaction Pathway
    11.3: Modeling Photosynthesis
    12: The Biochemistry of Zinc
    12.1: An Overview of Zinc
    12.2: Zinc Enzymes
    12.2.1: Carboanhydrases
    12.2.2: Hydrolases
    12.2.3: Alcohol Dehydrogenase
    12.3: The Role of Zinc in the Transcription of Genes
    12.4: Thioneins
    13: Metal- and Metalloid-Carbon Bonds
    13.1: Organometallic Compounds of Transition Metals
    13.2: Carbon Bonds to Main Group Metals and Metalloids
    14: Inorganics in Medicine
    14.1: Metals and Metalloids: An Introduction
    14.2: Dysfunction of Iron and Copper Homeostasis
    14.2.1: Iron
    14.2.2: Copper
    14.3: Metals and Metalloids in Therapy
    14.3.1: Historical and General Notes
    14.3.2: Treatment of Arthritis with Gold Compounds
    14.3.3: Cancer Treatment
    14.3.4: Further Metal Based Medications
    14.3.5: Radiopharmaceuticals
    14.4: Metals and Metalloids in Diagnostic Imaging
    14.5: The Toxic and Therapeutic Potential of CO, NO and H2S

Reviews

"Until now, our bookshelves have lacked a modern and conceptual textbook on bioinorganic chemistry. Rehder's Bioinorganic Chemistry now fills that gap. This textbook covers general concepts, discusses current literature, and inspires students for individual additional examinations. For these reasons, I strongly recommend this textbook for students and will incorporate it into my future teaching." - Angewandte Chemie International Edition, 2014, Issue 53

Additional Resources

Online Resource Centre
The Online Resource Centre to accompany Bioinorganic Chemistry features figures from the book in electronic format, for use in lecture slides and other teaching materials.