Bioinorganic Chemistry

Description

Bioinorganic Chemistry provides a broad overview of this dynamic field, reviewing the key chemical elements that have important biological function, and exploring how the chemistry of these elements is central to the function of biological systems.

• A truly student-friendly account of this buoyant area of chemistry
• Broad, balanced coverage makes it the perfect resource for those encountering the field for the first time, and for those who wish to deepen and to broaden their expertise
• Places particular emphasis on the biological function of the chemical elements, unifying the fields of chemistry and biology in a coherent way
• Sidebars discuss the analytical approaches adopted to study bioinorganic systems, helping readers to appreciate the experimental basis of the subject
• An Online Resource Centre provides additional teaching materials for lecturers

About the Author(s)

Dieter Rehder, University of Hamburg, Germany

Dieter Rehder is a Professor in the Institute of Inorganic and Applied Chemistry, University of Hamburg where his main fields of research include organometallic, bioinorganic and medicinal chemistry (of vanadium), oxido- and sulfidometal clusters, and metal NMR. Dieter was winner of the Vanadis Award 2006 for outstanding research in the field of vanadium chemistry.

Table of Contents

Introduction
1:Bio-Elements in the Periodic Table
2:Pre-Life and Early Life Forms; extremophiles
3:The Alkaline and Alkaline Earth Metals
3.1:Overview
3.2:Ion Channels
3.3:Sodium and Potassium
3.4:Magnesium
3.5:Calcium
4:Iron: General Features of its Inorganic Chemistry and Biochemistry
4.1:General, and Aqueous Chemistry
4.2:Mobilization, Transport, Delivery, and Mineralization of Iron
5:Oxygen Transport and the Respiratory Chain
5.1:Oxygen and oxygen transport by haemoglobin and myoglobin
5.2:Oxygen transport by hemerythrin and haemocyanin
5.3:The Respiratory Chain
6:Oxidoreductases Based on Iron, Manganese, and Copper
6.1:Ribonucleotide Reductases
6.2:Superoxide dismutases, superoxide Reductases, and peroxidases
6.3:Oxygenases and oxidases
7:Oxo-transfer Proteins Based on Molybdenum, Tungsten, and Vanadium
7.1:Molybdo- and Tungsto-pyranopterins
7.1.1:The Xanthine Oxidase Family
7.1.2:The Sulfite Oxidase Family
7.1.3:The Dimethylsulfoxide (DMSO) Reductase Family
7.2:Vanadate-dependent Haloperoxidases
7.3:Model Chemistry
8:The Sulfur Cycle
8.1:Environmental Sulfur Cycling
8.2:Biogenic Metabolism of Sulfur
9:Nitrogenase and Nitrogen Cycle Enzymes
9.1:Overview and Native Nitrogenase
9.2:Nitrogenase Models and Model Reactions
9.3:Denitrification
9.4:Nitric Oxide
10:The Methane Cycle and Nickel Enzymes
10.1:Introduction
10.2:Methanogenesis
10.3:Biogenic Oxidation of Methane
10.4:Nickel Enzymes not Involved in Methane Metabolism
11:Photosynthesis
11.1:Overview
11.2:The Reaction Pathway
11.3:Modeling Photosynthesis
12:The Biochemistry of Zinc
12.1: An Overview of Zinc
12.2:Zinc Enzymes
12.2.1:Carboanhydrases
12.2.2:Hydrolases
12.2.3:Alcohol Dehydrogenase
12.3:The Role of Zinc in the Transcription of Genes
12.4:Thioneins
13:Metal- and Metalloid-Carbon Bonds
13.1:Organometallic Compounds of Transition Metals
13.2:Carbon Bonds to Main Group Metals and Metalloids
14:Inorganics in Medicine
14.1:Metals and Metalloids: An Introduction
14.2:Dysfunction of Iron and Copper Homeostasis
14.2.1:Iron
14.2.2:Copper
14.3:Metals and Metalloids in Therapy
14.3.1:Historical and General Notes
14.3.2:Treatment of Arthritis with Gold Compounds
14.3.3:Cancer Treatment
14.3.4:Further Metal Based Medications
14.3.5:Radiopharmaceuticals
14.4:Metals and Metalloids in Diagnostic Imaging
14.5:The Toxic and Therapeutic Potential of CO, NO and H2S

Reviews

"Until now, our bookshelves have lacked a modern and conceptual textbook on bioinorganic chemistry. Rehder's Bioinorganic Chemistry now fills that gap. This textbook covers general concepts, discusses current literature, and inspires students for individual additional examinations. For these reasons, I strongly recommend this textbook for students and will incorporate it into my future teaching." - Angewandte Chemie International Edition, 2014, Issue 53

Additional Resources

Online Resource Centre
The Online Resource Centre to accompany Bioinorganic Chemistry features figures from the book in electronic format, for use in lecture slides and other teaching materials.