An Introduction to Medicinal Chemistry

Description

The market-leader in medicinal chemistry: clear, supportive, and practical. It helps students to effortlessly make the link from theory to real-life applications using practical and focused coverage alongside a package of supportive online resources.

• The author's renowned clarity of writing and the book's logical structure help to address the challenges of teaching and studying Medicinal Chemistry.
• New chapters on Protein Kinase and Antibodies provide insightful, up-to-date coverage of some of the most significant topics in the subject today
• The pedagogical features enhance student engagement, which supports better knowledge retention, and a more confident application of concepts and ideas to unfamiliar problems.
• Boxes and case studies support a real-life applied approach that helps lecturers to show how theoretical content relates to the practical reality of medicinal chemistry.
• Full-colour images throughout the new edition enhance the student experience by helping them to better visualise the concepts presented.
• New and updated exercises, questions, and activities throughout the book and online help students to hone their problem-solving skills.
• Also available as an e-book with functionality, navigation features, and links that offer extra learning support.

New to this edition

• Newly added high-level Multiple-Choice Questions to support self-directed learning and challenge the understanding of the processes and concepts covered
• Updated and new Protein Data Bank Exercises available online.
• New and updated assignments to help students develop their data analysis and problem-solving skills
• Full-colour images throughout the new edition enhance the student experience by helping them to better visualise the concepts presented.
• Also available as an e-book with functionality, navigation features, and links that offer extra learning support.

About the Author(s)

Graham L. Patrick, Associate Lecturer, University of the West of Scotland

Dr Graham L. Patrick gained his BSc Honours at Glasgow University, winning the McKay-Smith Prize for Chemistry. He completed his PhD with Professor Kirby and Professor Robins studying the biosynthesis of gliotoxin and related fungal metabolites. Following this, he worked in the pharmaceutical industry as a research chemist and radiochemist on a variety of projects that included topic areas such as opioids, antibacterial agents and antidepressants. His academic career has included positions at Leeds and Strathclyde Universities as well as the Australian National University. He joined the University of Paisley (now the University of the West of Scotland) in 1990, teaching medicinal chemistry and drug design. Currently, he is an Associate Lecturer with the Open University, an author of scientific textbooks and fiction, and an historical archivist

Table of Contents

1:Drugs and Drug Targets
2:Protein Structure and Function
3:Enzymes: Structure and Function
4:Receptors: Structure and Function
5:Receptors and Signal Transduction
6:Nucleic Acids: Structure and Function
7:Enzymes as Drug Targets
8:Receptors as Drug Targets
9:Nucleic Acids as Drug Targets
10:Miscellaneous Drug Targets
11:Pharmacokinetics and Related Topics
Case Study 1:Statins
12:Drug Discovery: Finding a Lead
13:Drug Design: Optimizing Target Interactions
14:Drug Design: Optimizing Access to the Target
15:Getting the Drug to Market
Case Study 2:The Design of ACE Inhibitors
Case Study 3:Artemisinin and Related Antimalarial Drugs
Case Study 4:The Design of Oxamni
Case Study 5:Fosfidomycin as an Antimalarial Agent
16:Combinatorial and Parallel Synthesis
17:In Silico Drug Design
18:Quantitative Structure-Activity Relationships
Case Study 6: De Novo Design of a Thymidylate Synthase Inhibitor
19:Antibacterial Agents
20:Antiviral Agents
21:Anticancer Agents
22:Protein Kinase Inhibitors as Anticancer Agents
23:Antibodies and Other Biologics
24:Cholinergics, Anticholinergics, and Anticholinestarases
25:Drugs Acting on the Adrenergic Nervous System
26:The Opioid Analgesics
27:Anti-Ulcer Agents
28:Cardiovascular Drugs
Case Study 7:Steroidal Anti-Inflammatory Agents
Case Study 8:Design of a Novel Antidepressant
Case Study 9:The Design and Development Of Aliskiren
Case Study 10:Factor Xa Inhibitors
Case Study 11:Reversible Inhibitors of HCV NS-34A Protease

Reviews

"The best general undergraduate textbook on medicinal chemistry. This new edition retains the accessible style of writing, but provides important updates on the topics." - Dr Mark Ashton, School of Pharmacy, Newcastle University, UK

"I read this masterpiece to build a strong knowledge of medicinal chemistry and it has helped me a lot. I would definitely recommend it to others. Detailed explanations of enzyme-substrate interactions and much more are very useful." - Jinkal Gondaria, MChem student, Manchester Metropolitan University, UK

"A very useful medical chemistry book and teaching tool. Great learning resources and easy to digest content." - Dr Silvia M.M.A. Pereira-Lima, Department of Chemistry, University of Minho, Portugal

Additional Resources

An Introduction to Medicinal Chemistry 7e is available for students and institutions to purchase in a variety of formats, and is supported by online resources.
· The e-book offers a mobile experience and convenient access along with hyperlinks to multiple-choice questions, Protein Data Bank exercises, and links to relevant web articles: www.oxfordtextbooks.co.uk/ebooks
Student resources: newly added multiple-choice questions, web articles providing further information, molecular modelling exercises, protein data bank exercises, and more, organised by chapter are available online.
Instructor resources: test bank of additional questions with links to relevant sections in the book, answers to end-of-chapter questions, figures from the book, and PowerPoint slides to accompany every chapter in the book.