An Introduction to Drug Synthesis

Description

An Introduction to Drug Synthesis explores the central role played by organic synthesis in the process of drug design and development - from the generation of novel drug structures to the improved efficiency of large scale synthesis.

• An introduction to the central role of organic synthesis in the development of therapeutically useful drugs
• Written by an author whose name has become synonymous with clear and engaging explanations
• The extensive use of examples and case studies reinforces the relevance of the subject matter to the synthesis of drugs and highlights the different synthetic strategies available
• An Online Resource Centre provides additional teaching and learning resources to augment the printed text

About the Author(s)

Graham L. Patrick, University of the West of Scotland

Graham Patrick is a lecturer in Organic Chemistry and Medicinal Chemistry at the University of the West of Scotland, Glasgow. He is the author of four other undergraduate textbooks covering medicinal chemistry and organic chemistry, including Introduction to Medicinal Chemistry, which is now in its fifth edition.

Table of Contents

PART A: Concepts
1:The drug discovery process
2:Drug synthesis
3:Retrosynthesis
4:Cyclic systems in drug synthesis
5:The synthesis of chiral drugs
6:Combinatorial and parallel synthesis
PART B: Applications of drug synthesis in the drug development process
7:Synthesis of lead compounds
8:Analogue synthesis in drug design
9:Synthesis of natural products and their analogues
10:Chemical and process development
11:Synthesis of isotopically labelled compounds
PART C: Design and synthesis of selected antibacterial agents
12:Design and synthesis of tetracyclines
13:Erythromycin and macrolide antibacterial agents
14:Quinolones and fluoroquinolones

Reviews

"This is a well-written guide to many of the key concepts in the application of organic synthesis to drug discovery and development." - Doody's Notes

Additional Resources

Online Resource Centre
An Introduction to Drug Synthesis is supported by an Online Resource Centre featuring:

For registered adopters:
- Figures from the book in electronic format;

For students:
- A suite of multiple-choice questions to support the learning process;
- Additional case studies
- More detailed descriptions of key synthetic reactions, as a source of further reference.