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Patrick: An Introduction to Medicinal Chemistry 5e

Journal Club

Suggested papers and discussion questions linked to topics covered in the book are provided below. These are both relevant to Chapter 21 of the book.

Journal Club 1 - Epigenetics. Tackling Cancer at the Molecular Level
Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, Morse EM, Keates T, Hickman TT, Felletar I, Philpott M, Munro S, McKeown MR, Wang Y, Christie AL, West N, Cameron MJ, Schwartz B, Heightman TD, La Thangue N, French CA, Wiest O, Kung AL, Knapp S* and Bradner JE. (2010) Selective inhibition of BET Bromodomains. Nature, 468, 1067–1073.
[Questions] [Answers]

Journal Club 2 - What a difference a methyl group makes!
Barreiro, EJ, Kummerle, AE and Fraga, CAM (2011) The Methylation Effect in Medicinal Chemistry, Chem. Rev., 111, 5215–5246.
[Questions] [Answers]