We use cookies to enhance your experience on our website. By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time. Find out more
Oxford University Press - Online Resource Centres

Elliott & Elliott: Biochemistry and Molecular Biology 4e

Chapter 33

Please note that some of the sites you will be directed to from this page may require a username and password to access the article.

Fearon, E. R. (1999). Cancer progression. Curr. Biol., 9, R873-5 [DOI: 10.1016/S0960-9822(00)80071-8].
A ?primer? article giving essential information very briefly.

Hanahan, D. and Weinberg, R. A. (2000). The hallmarks of cancer. Cell 100, 57-70 [DOI: 10.1016/S0092-8674(00)81683-9] [PubMed: 10647931].
Includes succinct statement of six essential alterations in cancer development.

Bernards, R. and Weinberg, R. A. (2002). A progression puzzle. Nature, 418, 823 [DOI: 10.1038/418823a] [PubMed: 12192390].
A one-page comment on cancer progression to metastasis.

Lu, J. et al. (2005). MicroRNA expression profiles classify human cancers. Nature, 435, 834-8 [DOI: 10.1038/nature03702] [PubMed: 15944708].

Ma, L., Teruya-Feldstein, J., and Weinberg, R. A. (2007). Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature, 449, 682-8 [DOI: 10.1038/nature06174] [PubMed: 17898713].

Karnoub, A. E., et al. (2007). Mesenchymal stem cells within a tumour stroma promote breast cancer metastasis. Nature, 449, 557-63 [DOI: 10.1038/nature06188] [PubMed: 17914389].


Johnson, F. B., Marcniak, R. A., and Guarente, L. (1998). Telomeres, the nucleolus and aging. Curr. Opin. Cell Biol., 10, 332-8 [DOI: 10.1016/S0955-0674(98)80008-2].
Discusses the relationship between telomere lengthening and replicative senescence. Includes discussion of the relationship to human ageing.


Cavanee, W. K. and White, R. L. (1995). The genetic basis of cancer. Sci. Am., 272(3), 50-7.
Describes the accumulation of genetic defects that can cause normal cells to become cancerous.

Diffley, J. F. X. and Evan, G. (1999). Oncogenes and cell proliferation. Cell cycle, genome integrity and cancer - a millennial view. Curr. Opin. Genet. Dev., 10, 13-16 [DOI: 10.1016/S0959-437X(99)00053-2].
An informative editorial overview of the whole field. It also refers to subsequent reviews in the same issue of the journal.

Tumour-suppressor genes

Brehm, A. and Kouzrides, T. (1999). Retinoblastoma protein meets chromatin. Trends Biochem. Sci., 24, 142-5 [DOI: 10.1016/S0968-0004(99)01368-7].
Discusses the effect of the tumour-suppressor retinoblastoma protein on chromatin remodelling.

Macleod, K. (2000). Tumor suppressor genes. Curr. Opin. Genet. Dev., 10, 81-93 [DOI: 10.1016/S0959-437X(99)00041-6].

p53 tumour suppressor

Elledge, R. M. and Lee, W.-H. (1995). Life and death by p53. BioEssays, 17, 923-30 [DOI: 10.1002/bies.950171105] [PubMed: 8526886].

Summarizes the many functions of the P53 gene product, including its role in cancer suppression. p53 tumour suppressor. (1998). Curr. Biol., 8, R476 [DOI: 10.1016/S0960-9822(98)70308-2].
A single-page quick guide giving salient facts of this important gene mentioning that at the time of publication there were 11,226 papers on the subject.

Lozano, G. and Elledge, S. J. (2000). P53 sends nucleotides to repair DNA. Nature, 404, 24-5 [DOI: 10.1038/35003670] [PubMed: 10716425].
A News and Views article describing a new aspect of the tumour suppressor p53, namely that it activates a gene coding for a subunit of ribonucleotide reductase. This produces the deoxyribonucleotides required for DNA replication and repair.

Caspari, T. (2000). Checkpoints: how to activate p53. Curr. Biol., 10, R315-7 [DOI: 10.1016/S0960-9822(00)00439-5].
Activation and stabilization involves protein kinase ATM

Sharpless, N. E. and DePinho, R. A. (2002). P53: good cop/bad cop. Cell 110, 9-12 [DOI: 10.1016/S0092-8674(02)00818-8] [PubMed: 12150992].
A minireview

DNA mismatch repair

Prolla, T. A. (1998). DNA mismatch-repair and cancer. Curr. Opin. Cell Biol., 10, 311-16 [DOI: 10.1016/S0955-0674(98)80005-7].
Mutations of mismatch repair proteins are associated with the development of tumours in mice and in humans.