Elliott & Elliott: Biochemistry and Molecular Biology 4e
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Fearon, E. R. (1999). Cancer progression. Curr. Biol., 9, R873-5 [DOI: 10.1016/S0960-9822(00)80071-8].
A ?primer? article giving essential information very briefly.
Hanahan, D. and Weinberg, R. A. (2000). The hallmarks of cancer. Cell 100, 57-70 [DOI: 10.1016/S0092-8674(00)81683-9] [PubMed: 10647931].
Includes succinct statement of six essential alterations in cancer development.
Johnson, F. B., Marcniak, R. A., and Guarente, L. (1998). Telomeres, the nucleolus and aging. Curr. Opin. Cell Biol., 10, 332-8 [DOI: 10.1016/S0955-0674(98)80008-2].
Discusses the relationship between telomere lengthening and replicative senescence. Includes discussion of the relationship to human ageing.
Diffley, J. F. X. and Evan, G. (1999). Oncogenes and cell proliferation. Cell cycle, genome integrity and cancer - a millennial view. Curr. Opin. Genet. Dev., 10, 13-16 [DOI: 10.1016/S0959-437X(99)00053-2].
An informative editorial overview of the whole field. It also refers to subsequent reviews in the same issue of the journal.
Brehm, A. and Kouzrides, T. (1999). Retinoblastoma protein meets chromatin. Trends Biochem. Sci., 24, 142-5 [DOI: 10.1016/S0968-0004(99)01368-7].
Discusses the effect of the tumour-suppressor retinoblastoma protein on chromatin remodelling.
Macleod, K. (2000). Tumor suppressor genes. Curr. Opin. Genet. Dev., 10, 81-93 [DOI: 10.1016/S0959-437X(99)00041-6].
p53 tumour suppressor
Summarizes the many functions of the P53 gene product, including its role in cancer suppression. p53 tumour suppressor. (1998). Curr. Biol., 8, R476 [DOI: 10.1016/S0960-9822(98)70308-2].
A single-page quick guide giving salient facts of this important gene mentioning that at the time of publication there were 11,226 papers on the subject.
Lozano, G. and Elledge, S. J. (2000). P53 sends nucleotides to repair DNA. Nature, 404, 24-5 [DOI: 10.1038/35003670] [PubMed: 10716425].
A News and Views article describing a new aspect of the tumour suppressor p53, namely that it activates a gene coding for a subunit of ribonucleotide reductase. This produces the deoxyribonucleotides required for DNA replication and repair.
Caspari, T. (2000). Checkpoints: how to activate p53. Curr. Biol., 10, R315-7 [DOI: 10.1016/S0960-9822(00)00439-5].
Activation and stabilization involves protein kinase ATM
DNA mismatch repair
Prolla, T. A. (1998). DNA mismatch-repair and cancer. Curr. Opin. Cell Biol., 10, 311-16 [DOI: 10.1016/S0955-0674(98)80005-7].
Mutations of mismatch repair proteins are associated with the development of tumours in mice and in humans.