Elliott & Elliott: Biochemistry and Molecular Biology 4e
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A commentary on the ENCODE project results which shows that genes may be far from compact assemblies but have regions scattered around the genome. Highly readable.
Zamore, P. D. (2001). RNA interference: listening to the sound of silence. Nat. Struct. Biol., 8, 746-50 [DOI: 10.1038/nsb0901-746].
Review on gene silencing.
Shi, Y. (2003). Mammalian RNAi for the masses. Trends Genet., 19, 9-12 [DOI: 10.1016/S0168-9525(02)00005-7].
The siRNAs (small interfering RNAs) are easily synthesized chemically. Their sequence specificity means that, in principle, any mRNA can be targeted to silence (or knockdown) expression of specific genes. Deals with potential medical applications.
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Natural antisense transcripts have been implicated in many aspects of eukaryotic gene expression.
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Very comprehensive, more suitable for instructors
Eckstein, F. (2005). Small non-coding RNAs as magic bullets. Trends Biochem. Sci., 30, 445-52 [DOI: 10.1016/j.tibs.2005.06.008].
Very good summary of all aspects
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This review examines the role of miRNAs in the pathogenesis of cancer as well as miRNA-profiling studies performed in human malignancies.
Mattick, J. (2007). A new paradigm for developmental biology. J. Exptl. Biol., 210, 1526-47 [DOI: 10.1242/jeb.005017].
Zhongxing. (2007). Blockade of invasion and metastasis of breast cancer cells via targeting CXCR4 with an artificial microRNA. Biochem. Biophys. Res. Commun., 363, 542-6 [DOI: 10.1016/j.bbrc.2007.09.007].
CXCR4 is a chemokine receptor
Nowacki, M., Vijayan, V., Zhou, Y., Schotanus. K., Doak, T. G., and Landweber, L. F. (2008). RNA-mediated epigenetic programming of a genome-rearrangement pathway. Nature, 451, 153-60 [DOI: 10.1038/nature06452] [PubMed: 18046331].