Elliott & Elliott: Biochemistry and Molecular Biology 4e
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A one-page guide
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An account of the ?unorthodox? genes - jumping genes, fragile chromosomes, expanded genes, edited mRNA, and nonstandard genetic code in mitochondria and chloroplasts.
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Reviews a meeting to mark the 40th anniversary of the double helix. Biochemical nostalgia, but which summarizes the landmarks in the area and looks to the future.
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Transcriptional complexity may be the answer to why humans have relatively few genes.
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Chromatin was found to be digested in a nonrandom manner.
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Reviews the nucleosome story
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Papers cover noncoding RNAs and RNA silencing
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An early prediction of the importance of RNA in gene control.
Nudler, E. and Mironov, A. S. (2004). The riboswitch control of bacterial metabolism. Trends Biochem. Sci., 29, 11-17 [DOI: 10.1016/j.tibs.2003.11.004].
Summary of the recent progress identifying small RNA aptamers, called ?riboswitches?. Found in the leader sequences of many metabolic genes they can repress or activate their cognate genes at both transcriptional and translational levels.
Gusella, J. F. and MacDonald, M. E. (2006). Huntington?s disease: seeing the pathogenic process through a genetic lens. Trends Biochem. Sci., 31, 533-40 [DOI: 10.1016/j.tibs.2006.06.009].
No authors quoted. (2007). Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature, 447, 799-816 [DOI: 10.1038/nature05874] [PubMed: 17571346].
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A commentary on the ENCODE project results which shows that genes may be far from compact assemblies but have regions scattered around the genome. Highly readable.