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Oxford University Press - Online Resource Centres

Elliott & Elliott: Biochemistry and Molecular Biology 4e

Chapter 20

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Antifolate drugs

Huennekens, F. M. (1994). The methotrexate story: a paradigm for development of cancer therapeutic agents. Adv. Enzyme Regul., 34, 392-419.
Gives history of the antifolate drug, the structure of dihydrofolate reductase, and development of methotrexate resistance in cells.