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Oxford University Press - Online Resource Centres

Elliott & Elliott: Biochemistry and Molecular Biology 4e

Chapter 09

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Digestion and absorption of fats

Riddihough, G. (1993). Picture of an enzyme at work. Nature, 362, 793 [DOI: 10.1038/362793a0] [PubMed: 8479515].
News and Views summary of how pancreatic lipase is activated in the digestion of fats.

Cholesterol transport

Attie, A. D. (2007). ABCA1 at the nexus of cholesterol, HDL and atherosclerosis. Trends Biochem. Sci., 32, 172-9 [DOI: 10.1016/j.tibs.2007.02.001].

Insulin resistance

Alper, J. (2000). New insights into Type 2 diabetes. Science, 289, 37-8 [DOI: 10.1126/science.289.5476.37] [PubMed: 10928926].

Arner, P. (2003). The adipocyte in insulin resistance: key molecules and the impact of thiazolidinediones. Trends Endocrin. Metab., 14, 137-45 [DOI: 10.1016/S1043-2760(03)00024-9].
A wide-ranging review relating to obesity and diabetes. Requires knowledge of cell signalling (Chapter 27).

Appetite control

Mechoulam, R. and Fride, E. (2001). A hunger for cannabinoids. Nature, 410, 763-4 [DOI: 10.1038/35071214] [PubMed: 11298428].
Links between cannabinoids and leptin

Schwartz, M. W. and Morton, G. J. (2002). Keeping hunger at bay. Nature, 418, 595-7 [DOI: 10.1038/418595a] [PubMed: 12167841].
News and Views article on the hormones that control eating.

Batterham, R. L., et al. (2002). Gut hormone PYY (3-36) physiologically inhibits food intake. Nature, 428, 650-2 [DOI: 10.1038/nature00887].

Bjorbaek, C. and Hellenberg, A. N. (2002). Leptin and melanocortin signaling in the hypothalamus. Vitam. Horm., 65, 281-311 [DOI: 10.1016/S0083-6729(02)65068-X].

Flier, J. and Maratos-Flier, E. (2000). Energy homeostasis and body weight. Curr. Biol., 10, R215-17 [DOI: 10.1016/S0960-9822(00)00393-6].

Marx, J. (2003). Cellular warriors at the battle of the bulge. Science, 299, 846-9 [DOI: 10.1126/science.299.5608.846] [PubMed: 12574615].

Flier, J. S. (2004). Obesity wars: molecular progress confronts an expanding epidemic. Cell 116, 337-50 [DOI: 10.1016/S0092-8674(03)01081-X] [PubMed: 14744442].
A comprehensive review dealing with leptin and other relevant adipocyte signalling molecules.

Muolo, D. M. and Newgard, C. B. (2006). Obesity related derangements in metabolic regulation. Annu. Rev. Biochem., 75, 367 [DOI: 10.1146/annurev.biochem.75.103004.142512].

Wagenmakers, A. (ed). (2006). The biochemical basis of health aspects of exercise. Essays in biochemistry, Portland Press U.K.
A student-orientated wide-ranging text which covers aspects of insulin and nitric oxide signalling and their roles in diabetes type 2, obesity, and vascular problems.

Roth, J. D., et al. (2008). Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies. Proc. Natl. Acad. Sci. U.S.A., 105, 7257-62 [DOI: 10.1073/pnas.0706473105] [PubMed: 18458326].