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Oxford University Press - Online Resource Centres

Elliott & Elliott: Biochemistry and Molecular Biology 4e

Chapter 04

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Branden, C. and Tooze, J. (1999). Introduction to protein structure, 2nd edn. Garland Publishing.

Lesk, A. M. (2001). Introduction to protein architecture. Oxford University Press.
An advanced treatise on the structural biology of proteins.

Protein size and structure

Chothia, C. (1984). Principles that determine the structure of proteins. Annu. Rev. Biochem., 53, 537-72 [DOI: 10.1146/annurev.bi.53.070184.002541].
Excellent for the basics of protein structure.

Goodsell, D. S. (1991). Inside a living cell. Trends Biochem. Sci., 16, 203-6 [DOI: 10.1016/0968-0004(91)90083-8].
Presents a picture of the distribution of molecules on a proper scale in a cell of E. coli.

Goodsell, D. S. (1993). Soluble proteins: size, shape and function. Trends Biochem. Sci., 18, 65-8 [DOI: 10.1016/0968-0004(93)90153-E].
A survey of protein structures - their size and shape. Why are they so big? Why are they oligomeric?

Gerlt J. A. and Babbitt P. C. (2001). Divergent evolution of enzymatic function: mechanistically diverse superfamilies and functionally distinct suprafamilies. Annu. Rev. Biochem., 70, 209-46 [DOI: 10.1146/annurev.biochem.70.1.209].

S?ding, J. and Lupas, A. N. (2003). More than the sum of their parts: on the evolution of proteins from peptides. BioEssays, 25, 837-46 [DOI: 10.1002/bies.10321].

Protein modules or domains

Doolittle, R. F. (1995). The multiplicity of domains in proteins. Annu. Rev. Biochem., 64, 287-314 [DOI: 10.1146/annurev.bi.64.070195.001443].
A discussion of domains, domain shuffling, exons, and introns. (The latter two topics are dealt with in Chapter 24 of this book.)

Proteins of hair and connective tissue

Francis, M. J. O. and Duksin, D. (1983). Heritable disorders of collagen metabolism. Trends Biochem. Sci., 8, 231-4 [DOI: 10.1016/0968-0004(83)90345-6].
A relatively simple account of this very complex and medically important field.

Hulmes, D. J. S. (1992). The collagen superfamily - diverse structures and assemblies. Essays Biochem., 27, 49-67.

Arcangelis, A. D. and Georges-Labouesse, E. (2002). Integrin and ECM functions: roles in vertebrate development. Trends Genet., 16, 389-94 [DOI: 10.1016/S0168-9525(00)02074-6].
Reviews signalling roles (ECM = extracellular matrix)

Mercer, J. F. B., et al., (1993). Isolation of a candidate gene for Menkes disease by positional cloning. Nat. Genet., 3, 20-5 [DOI: 10.1038/ng0193-20].

Hymes, R. D. (2002). Integrins: bidirectional, allosteric signalling machines. Cell 20, 673-87 [DOI: 10.1016/S0092-8674(02)00971-6].

Wheelock, M. J. and Johnson, K. R. (2003). Cadherins as modulators of cellular phenotype. Ann. Rev. Cell Dev. Biol., 19, 207-35 [DOI: 10.1146/annurev.cellbio.19.011102.111135].
A comprehensive review. Probably suitable for instructors rather than students.

Nelson W. J. and Nusse, R. (2004) Convergence of Wnt, β-Catenin, and Cadherin pathways. Science, 303, 1483-7 [DOI: 10.1126/science.1094291] [PubMed: 15001769].
An advanced review describing the cellular arrangements and control of cell migration by cadherins. Suitable for instructors rather than students.