Vaccines for the Prevention of Cervical Cancer

Edited by Peter Stern and Henry Kitchener

Oxford Oncology Library

DT Helpful Key Points at the beginning of each chapter to summarise content
DT Portable, accessible format for quick reference
DT Includes up-to-date research literature that has direct clinical application for busy healthcare professionals
Includes updated trial data in the chapter on prophylactic HPV vaccination: current status

Vaccines for the Prevention of Cervical Cancer

Edited by Peter Stern and Henry Kitchener

Description

Cervical cancer is the second most common form of cancer found in women and is responsible for more than a quarter of a million deaths worldwide each year. With approximately 70% of cervical cancers now known to be caused by two oncogenic types of the human papillomavirus (HPV), there is great interest surrounding the approval of the vaccine for clinical use. Despite this, many questions remain about how the new vaccines should be implemented and how cervical cancer screening will change following vaccination.

This practical pocketbook provides an overview of the role of HPV in the pathophysiology of cervical cancer and its current screening and management, the principles of immune control of HPV infection in cervical cancer, and the challenges of implementing HPV vaccines and future developments. This revised edition includes updated trial data in the chapter on prophylactic HPV vaccination: current status.

Vaccines for the Prevention of Cervical Cancer

Edited by Peter Stern and Henry Kitchener

Oxford Oncology Library

1. The UK cervical screening programme, Karin Denton
2. Management of cervical intraepithelial neoplasia (CIN), Julia E. Palmer and John A Tidy
3. Role of HPV in cervical carcinogenesis, Sally Roberts and Lawrence S. Young
4. HPV and genital cancer: the essential epidemiology, F. Xavier Bosch, Silvia de Sanjose, and Xavier Castallsague
5. The role of HPV testing in cervical screening, Margaret E. Cruickshank
6. Natural immune control of HPV infection, Peter L. Stern
7. Prophylactic HPV vaccines: pre-clinical and proof of principle studies, Margaret A. Stanley
8. Prophylactic HPV vaccination: current status, Henry C. Kitchener
9. Introduction of HPV prophylactic vaccination, Loretta Brabin
10. HPV vaccination in the developing world, Rengaswamy Sankaranarayanan and Catherine Sauvaget
11. Screening post vaccination, Patrick Walker, Adeola Atilade, and Henry C. Kitchener
12. Second-generation HPV prophylactic vaccines, Richard BS Roden
13. Therapeutic HPV vaccines, Sjoerd H. van der Burg
14. Conclusion, Peter L. Stern and Henry C. Kitchener

Vaccines for the Prevention of Cervical Cancer

Edited by Peter Stern and Henry Kitchener

Oxford Oncology Library

Author Information

Peter L. Stern is Professor of Immunology, Patterson Institute of Cancer Research, Christie Hospital NHS Trust, University of Manchester, Manchester, UK

Henry C. Kitchener is Professor of Gynacological Oncology at St. Mary's Hospital, University of Manchester, manchester, UK

Contributors:

Xavier Bosch, Servei d'Epidemiologia i Resgistre del Càncer, 2ª Planta, Institut Català d'Oncologia, L'Hospitalet de Llobregat, Barcelona, Spain
Loretta Brabin, Academic Unit of Obstetrics and Gynaecology, St Mary's Hospital, Whitworth Park, Manchester, UK
Xavier Castellsagué, Servei d'Epidemiologia i Resgistre del Càncer, 2ª Planta, Institut Català d'Oncologia, L'Hospitalet de Llobregat, Barcelona, Spain
Maggie Cruickshank, Senior Lecturer in Gynaecology, University of Aberdeen Medical School, King's College
Aberdeen, UK
Karin Denton, Consultant Cytopathologist, Department of Pathology, Southmead Hospital, Westbury on Trym, Bristol, UK
Henry C. Kitchener, Professor of Gynaecological Oncology, St Mary's Hospital, Whitworth Park, Manchester, UK
Julia Palmer, Subspecialty Trainee in Gynaecological Oncology, Department of Gynaecological Oncology, Sheffield Hospitals NHS Trust, Sheffield, UK
Sally Roberts, Senior Lecturer, Division of Cancer Studies, University of Birmingham Medical School, Edgbaston
Birmingham, UK
Richard Roden, Associate Professor, Department of Pathology, John Hopkins University School of Medicine, Baltimore, USA
Silvia de Sanjosé, Servei d'Epidemiologia i Resgistre del Càncer 2ª Planta, Institut Català d'Oncologia, L'Hospitalet de Llobregat, Barcelona, Spain
R Sankaranarayanan, Head, Screening Group, International Agency for Research on Cancer, Lyon, France
C. Sauvaget, Screening Group, International Agency for Research on Cancer, Lyon, France
Margaret Stanley, Department of Pathology, University of Cambridge, Cambridge, UK
Peter L. Stern, Group Leader, UK Immunology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, University of Manchester, Withington, Manchester, UK
John Tidy, Consultant in Obstetrics and Gynaecology, Sheffield Teaching Hospitals, Northern General Hospital, Sheffield, UK
Sjoerd H. van der Burg, Associate Professor, Head of Laboratory of Clinical Oncology, Leiden University Medical Center
Leiden, the Netherlands.
Patrick Walker, Consultant, Department of Obstetrics and Gynaecology, Royal Free Hospital, London, UK
Lawrence Young, Professor of Cancer Biology, Head of Division of Cancer Studies, Cancer Research UK Institute for Cancer Studies, University of Birmingham Medical School, Edgbaston, Birmingham, UK