The Vein Book

Second Edition

Edited by John J. Bergan and Nisha Bunke-Paquette

Fully updated from the previous edition to include recent discoveries in the field, technological advances, and new venous procedures
The must-have resource on the condition and treatment of varicose veins, spider veins, and thread veins

The Vein Book

Second Edition

Edited by John J. Bergan and Nisha Bunke-Paquette

Description

Since its initial publication nearly a decade ago, The Vein Book continues to serves as the ultimate comprehensive resource on venous disease. Upholding its reputation as the go-to reference for complete, authoritative, and up-to-date information about venous function and dysfunction, this second edition effectively bridges the gap between clinical medicine and basic science, suitable both for the seasoned surgeon as well as the medical student.

The book is divided into five essential sections: basic considerations, primary superficial venous insufficiency, venous thromboembolism, chronic venous insufficiency, and congenital venous malformations. The book covers the entire spectrum of venous conditions from clarification of the pathophysiology of venous insufficiency, molecular mechanisms in the cause of varicose veins, new treatment options for varicose veins and spider veins, startling new treatment for venous thromboembolic disease, and effective treatment for leg ulcers.

More user-friendly and encyclopedic than ever, The Vein Book is still a must-have for vascular surgeons, phlebologists, interventional radiologists, research scientists, epidemiologists, and surgeons at all levels.

The Vein Book

Second Edition

Edited by John J. Bergan and Nisha Bunke-Paquette

Part I: Basic Considerations

1. Historical Introduction
Alberto Caggiati and Claudio Allegra

2. Venous Embryology and Anatomy
Geza Mozes and Peter Gloviczki

3. Epidemiology of Chronic Peripheral Venous Disease
Michael H. Criqui, Julie O. Denenberg, Robert D. Langer, Robert M. Kaplan, and Arnost Fronek

4. Venous Anatomy, Physiology, and Pathophysiology
John J. Bergan and Luigi Pascarella

5. Physiologic Testing in Venous Disorders
Jeffrey K. Raines and Jose I. Almeida

6. Inappropriate Leukocyte Activation in Venous Disease
Philip Coleridge Smith

7. Molecular Basis of Venous Insufficiency

8. Chronic Venous Insufficiency: Molecular Abnormalities and Ulcer Formation
Joseph D. Raffetto

9. Pathophysiology of Chronic Venous Insufficiency
Peter J. Pappas, Brajesh K. Lal, Frank T. Padberg Jr., Robert W. Zickler, and Walter N. Duran

10. Mechanism and Effects of Compression Therapy
Hugo Partsch

11. Classifying Venous Disease
Bo Elkof

Part II: Primary Superficial Venous Insufficiency

12. Risk Factors, Manifestations, and Clinic Examination of the Patient with Primary Venous Insufficiency
John J. Bergan

13. Sclerosing Agents
A. Cavezzi and M. Izzo

14. Sclerotherapy Treatment of Telangiectasias
Robert A. Weiss and Margaret A. Weiss

15. Complications and Adverse Sequelae of Sclerotherapy
Mitchel P. Goldman

16. Laser Treatment of Telangiectasias and Reticular Veins
Neil Sadick and Lian Sorhaindo

17. Overview: Treatment of Venous Insufficiency
John J. Bergan

18. Ultrasound Examination of the Patient with Primary Venous Insufficiency
Luigi Pascarella and Lisa Mekenas

19. Sclerotherapy and Ultrasound Sclerotherapy
Paul K. Thibault

20. Sclerofoam for Treatment of Varicose Veins
Jeanjerome Guex

21. Sclerosants in Microfoam: A New Approach in Angiology
Juan Cabrera, Maria V. Rubia, and Juan Cabrera Jr.

22. Ultrasound Guided Catheter and Foam Therapy for Venous Insufficiency
Luigi Pascarella and John J. Bergan

23. Principles of Treatment of Varicose Veins
Steven E. Zimmet

24. Inversion Stripping of the Saphenous Vein
John J. Bergan

25. Neovascularization: An Adverse Response to Proper Groin Dissection
Marianne De Maeseneer

26. The Changing Importance of the Saphenous Vein: Treating vs. Non-treatment
Paul Pittaluga, Chastanet S, Locret T

27. Principles of Ambulatory Phlebectomy
Jose I. Almeida and Jeffrey K. Raines

28. Powered Phlebectomy in Surgery of Varicose Veins
Nick Morrison

29. Endovenous Radiofrequency and Laser Ablation
Nick Morrison

30. Treatment of Small Saphenous Vein Reflux
Kenneth Myers, Amy Clough, Stefania Roberts, and Damien Jolley

31. Recurrent Varicose Veins After Operative Treatment
Michel Perrin

32. Use of System-Specific Questionnaires and Determination of Quality of Life After Treatment of Varicose Veins
A C Shepherd, M Davis, and A H Davies

33. Pelvic Congestion Syndrome: Diagnosis and Treatment
G D Richardson

Part III: Venous Thromboembolism

34. The Epidemiology of Venous Thromboembolism in the Community: Implications for Prevention and Management
John A. Heit

35. Fundamental Mechanisms in Venous Thrombosis: New Insights
Jose A. Diaz, Daniel D. Myers Jr., and Thomas W. Wakefield

36. Congenital and Acquired Hypercoagulable Syndromes
Jocelyn A. Segall and Timothy K. Liem

37. New Ways To Prevent Venous Thromboembolism: Inhibition of Factor Xa and Thrombin
David Bergqvist

38. Diagnosis of Deep Venous Thrombosis
David A. Frankel and Warner P. Bundens

39. Thrombotic Risk Assessment: A Hybrid Approach
Joseph A. Caprini

40. Venous Thromboembolism Prophylaxis in the General Surgical Patient
J.I. Arcelus and Joseph A. Caprini

41. Conventional Treatment of Deep Venous Thrombosis
Graham F. Pineo and Russell D. Hull

42. The Diagnosis and Management of Heparin-Induced Thrombocytopenia
Theodore E. Warkentin

43. Operative Venous Thrombectomy
Anthony J. Comerota and Steven S. Gale

44. Permanent Vena Cava Filters: Indications, Filter Types, and Results
Ali F. AbuRahma and Patrick A. Stone

45. Complications of Vena Cava Filters
Teresa L. Carman and Linda M. Graham

46. Temporary Filters and Prophylactic Indications
John C. McCallum and Nikhil Kansal

47. Thrombolytic Therapy for Acute Venous Thrombosis
Anthony J. Comerota and Santiago Chahwan

48. Percutaneous Mechanical Thrombectomy in the Treatment of DVT
Colleen M. Johnson, Pritham P. Reddy, and Robert B. McLafferty

49. Diagnosis and Management of Primary Axillo-Subclavian Venous Thrombosis
Niren Angle

50. Subclavian Vein Obstruction: Techniques for Repair and Bypass
Richard J. Sanders

51. Superficial Thrombophlebitis: Recommendations for Diagnosis and Management
Joann M. Lohr

Part IV: Chronic Venous Insufficiency

52. The Primary Cause of Chronic Venous Insufficiency
Michel Perrin, Oscar Maleti, and Marzia Lugli

53. Conventional Surgery for Chronic Venous Insufficiency
William Marston

54. Subfascial Endoscopic Perforating Vein Surgery (SEPS) for Chronic Venous Insufficiency
Peter Gloviczki, Manju Karla, and Alessandra Puggioni

55. Ultrasound Guided Sclerotherapy of Perforating Veins In Chronic Insufficiency
Fedor Lurie, Alessandra Puggionu, and Robert L. Kistner

56. Perforating Veins
John J. Bergan and Luigi Pascarella

57. Endovenous Treatment of Iliocaval Occlusion
Patricia E. Thorpe and Francisco J. Osse

58. Popliteal Venous Entrapment
Seshadri Raju

59. Valvuloplasy In Primary Venous Insufficiency: Development, Performance, and Long-Term Results
Robert L. Kistner, Elna Masuda, and Fedor Lurie

60. Prosthetic Venous Valves
Michael C. Dalsing

61. Post-Thrombotic Syndrome: Clinical Features, Pathology, and Treatment
Seshadri Raju

62. Efficacy of Veno-Active Drugs In Chronic Venous Disease: Survey Of Evidence, Synthesis, And Tentative Recommendations
Michel Perrin and A.A. Ramelet

63. Medical Management of the Venous Leg Ulcer: Wound Dressings and Adjuvant Agents

Part V: Congenital Venous Abnormalities

64. Venous Malformations and Tumors: Etiology, Diagnosis, and Management
BB Lee and J Laredo

The Vein Book

Second Edition

Edited by John J. Bergan and Nisha Bunke-Paquette

Author Information

John J. Bergan, MD, FACS, FACPh, FRCS, pioneered a new era of diagnosis and treatment for venous conditions, expanding the scope of research and discovering new frontiers in phlebology. As a clinical vascular surgeon, physician, scientist, and respected teacher of vascular surgery, he has published over 800 academic papers and authored or edited more than 40 textbooks. He has served as president for all the major vascular surgery societies and resided on editorial boards of all major surgical and vascular journals, including the Journal of Vascular Surgery, Annals of Vascular Surgery, and the British Journal of Surgery. Additionally, he was a co-founder of the American Venous Forum and American College of Phlebology.

Nisha Bunke-Paquette, MD, FACPh, is the Director of La Jolla Vein Care, Volunteer Clinical Instructor of Surgery at the University of California San Diego School of Medicine, member of the Scripps Ximed Medical Group.

Contributors:

Ali F. AbuRahma
Department of Surgery
Robert C. Byrd Health Sciences Center
West Virginia University
Charleston, WV

Claudio Allegra
Department of Anatomy
University La Sapienza
Rome, Italy

Jose I. Almeida
Miami Vein Center
Miami, FL

Niren Angle
University of California, San Diego Medical Center
San Diego, CA

J. I. Arcelus
Hospital Virgen de las Nieves
University of Granada
Department of Surgery
Granada, Spain

John J. Bergan
The Vein Institute of La Jolla
La Jolla, CA

David Bergqvist
Department of Surgery
Uppsala University Hospital
Uppsala, Sweden

Warner P. Bundens
Department of Surgery
Department of Family and Preventitive Medicine
University of California, San Diego
La Jolla, CA

Juan Cabrera
Granada, Spain

Juan Cabrera Jr.
University Clinic of Navarra
Granada, Spain

Alberto Caggiati
Department of Anatomy
University La Sapienza
Rome, Italy

Joseph A. Caprini
Department of Surgery
Evanston Northwestern Healthcare
Evanston, IL

Teresa L. Carman
Director, Vascular Medicine
University Hospitals Case Medical Center
Assistant Professor of Medicine
Case Western Reserve University School of Medicine
Cleveland, OH

A. Cavezzi
Vascular Unit
Poliambulatorio Hippocrates
Clinic Stella Maris
Tronto, Italy

Santiago Chahwan
Jobst Vascular Center
The Toledo Hospital
Toledo, OH

S. Chastanet
Riviera Veine Institut
Monaco

Amy Clough
Melbourne Vascular Ultrasound
Melbourne, Australia

Anthony J. Comerota
Jobst Vascular Center
The Toledo Hospital
Toledo, OH

Michael H. Criqui
Division of Preventative Medicine
University of California, San Diego
La Jolla, CA

Michael C. Dalsing
School of Medicine
Indiana University
Indianapolis, IN

Alun H. Davies
Charing Cross Hospital
London, England

Meryl Davis
Charing Cross Hospital
London, England

Marianne De Maeseneer
Department of Thoracic and Vascular Surgery
University Hospital of Antwerp
Edegem, Belgium

Julie O. Denenberg
Division of Preventative Medicine
University of California, San Diego
La Jolla, CA

Jose A. Diaz
Katy, TX

Walter N. Duran
New Jersey Medical School
Newark, NJ

Bo Eklöf
Doctors Office Center
Helsingborg, Sweden

Steve Elias
Division of Vascular Surgery Vein Programs
Columbia University
New York, NY

David A. Frankel

Arnost Fronek
University of California, San Diego
La Jolla, CA

Steven S. Gale
Jobst Vascular Center
The Toledo Hospital
Toledo, OH

Peter Gloviczki
Department of Vascular Surgery
Mayo Clinic
Rochester, MN

Mitchel P. Goldman
Dermatology/Cosmetic Laser Associates of La Jolla, Inc.
La Jolla, CA

Linda M. Graham
Department of Biomedical Engineering
Cleveland Clinic Lerner Research Institute
Cleveland, OH

Jean-Jérôme Guex
Phlebology Clinic
Nice, France

John A. Heit
Mayo Clinic
Hematology Research
Rochester, MN

Russell D. Hull
Foothills Hospital
University of Calgary
Calgary, Alberta, Canada

M. Izzo
Interdepartmental Research Center
Mathematics for Technology, Medicine & Bioscience
University of Ferrara
Ferrara, Italy

Colleen M. Johnson
Division of Vascular Surgery
Department of Surgery
Southern Illinois University School of Medicine
Springfield, IL

Damien Jolley
Faculty of Medicine
Monash University
Victoria, Australia

Manju Kalra
Department of Vascular Surgery
Mayo Clinic
Rochester, MN

Nikhil Kansal
University of California, San Diego
San Diego, CA

Robert M. Kaplan
Department of Health Services
UCLA School of Public Health
Los Angeles, CA

Robert L. Kistner
Kistner Vein Clinic
Honolulu, HI

Brajesh K. Lal
Department of Surgery
University of Maryland Medical Center (UMMC)
Baltimore, MD

Robert D. Langer
Jackson Hole Center for Preventive Medicine
Jackson, WY

J Laredo
Division of Vascular Surgery
Department of Surgery
George Washington University School of Medicine
Washington, D.C.

BB Lee
Division of Vascular Surgery
Department of Surgery
George Washington University School of Medicine
Washington, D.C.

Timothy K. Liem
Vascular Surgery
Oregon Health & Science University
Portland, OR

T. Locret
Riviera Veine Institut
Monaco

Joann M. Lohr
Cincinnati, OH

Fedor Lurie
Kistner Vein Clinic
Honolulu, HI

Oscar Maleti
Senior Consulting in Vascular Surgery
Hesperia Hospital Modena

William Marston
Division of Vascular Surgery
University of North Carolina, Chapel Hill
Chapel Hill, NC

Elna Masuda
Straub Clinic & Hospital
Honolulu, HI

John C. McCallum
San Diego, CA

Robert B. McLafferty
Division of Vascular Surgery
Department of Surgery
Southern Illinois University
School of Medicine
Springfield, IL

Lisa Mekenas
Vascular Lab
Sharp Memorial Hospital
Department of Radiology
San Diego, CA

Nick Morrison
Morrison Vein Institute
Scottsdale, AZ

Geza Mozes
Department of Vascular Surgery
Mayo Clinic
Rochester, MN

Daniel D. Myers Jr.
University of Michigan Health Systems
Jobst Vaascular Research Lab
Ann Arbor, MI

Kenneth Myers
Epworth Hospital, Vascular Unit
Richmond, Australia

Francisco J. Osse
Venaclinic
Sao Paulo, Brazil

Frank T. Padberg Jr.
New Jersey Medical School
Newark, NJ

Peter J. Pappas
New Jersey Medical School
Newark, NJ

Hugo Partsch
Professor of Dermatology
University of Vienna
Vienna, Austria

Luigi Pascarella
The Vein Institute of La Jolla
La Jolla, CA

Michel Perrin
Chemlin de Decines
Clinique du Grande Large
Chassieu, France

Graham F. Pineo
Foothills Hospital
Calgary, Alberta, Canada

Paul Pittaluga
Riviera Veine Institut
Monaco

Alessandra Puggioni
Scottsdale Vascular Services
Scottsdale, AZ

Joseph D. Raffetto
VA Boston Healthcare System
Boston, MA

Jeffrey K. Raines
Miami Vein Center
Miami, FL

Seshadri Raju
The RANE Center for Venous and Lymphatic Diseases
River Oaks Hospital
Jackson, MS

Albert-Adrien Ramelet
Lausanne, Switzerland

Pritham P. Reddy
Division of Vascular Surgery
Department of Surgery
Southern Illinois University School of Medicine
Springfield, IL

Stefania Roberts
Victoria Vein Clinic
East Melbourne, Australia

Graeme D. Richardson
Rural Clinical School
Wagga Wagga, NSW, Australia

Maria V. Rubia

Robert B. Rutherford
The University of Colorado Medical Center/School
Corpus Christi, TX

Neil Sadick
Sadick Dermatology
New York, NY

Richard J. Sanders
Denver, CO

Geert W. Schmid-Schönbein
Department of Bioengineering
University of California, San Diego
La Jolla, CA

Jocelyn A. Segall
Vascular Surgery
Oregon Health & Science University
Portland, OR

A C Shepherd

Philip Coleridge Smith
British Vein Institute
London, UK

Lian Sorhaindo
Weill Cornell Medical College of Cornell University
New York, NY

Patrick A. Stone
Charleston, WV

Paul Thibault
Central Vein & Cosmetic Medical Centre
Broadmeadow, NSW, Australia

Patricia E. Thorpe
Department of Surgery
University of Iowa Health Care
Iowa City, IA

Thomas W. Wakefield
Department of Vascular Surgery
University of Michigan
Ann Arbor, MI

Theodore E. Warkentin
Professor, Pathology and Molecular Medicine
McMaster University
Hamilton Regional Laboratory Medicine Program
Hamilton General Hospital
Hamilton, Ontario, Canada

Margaret A. Weiss
Johns Hopkins School of Medicine
Baltimore, MD

Robert A. Weiss
Johns Hopkins School of Medicine
Baltimore, MD

Robert W. Zickler
New Jersey Medical School
Newark, NJ

Steven E. Zimmet
Zimmet Vein and Dermatology Clinic
Austin, TX

The Vein Book

Second Edition

Edited by John J. Bergan and Nisha Bunke-Paquette

Reviews and Awards

"This continues to be the go-to book for venous disease. This second edition is complete with up-to-date, evidence-based information on medical therapy, minimally invasive and surgical procedures, and other aspects of treatment. The tables, diagrams, illustrations, and photographs make for a very helpful addendum to the detailed but easy-to-read text. This is a must-read for vascular trainees who might not get much exposure to venous disease in their training programs. And it should be included in libraries of anyone taking care of patients with venous disease." --Doody's Health Sciences Book Review