The Genetic Basis of Common Diseases

Second Edition

Edited by Richard A. King, Jerome I. Rotter, and Arno G. Motulsky

Oxford Monographs on Medical Genetics

This is the only comprehensive volume on genetic factors in common adult diseases. Its high quality and consistent organization make it the best reference for physicians, geneticists, epidemiologists, biomedical researchers, students and others interested in these problems. For the second edition, the entire book has been updated and 12 new chapters have been added on such topics as osteoporosis, prostate cancer, skin diseases, mitochondrial disorders, and the genetic effects of drug therapy.

The Genetic Basis of Common Diseases

Second Edition

Edited by Richard A. King, Jerome I. Rotter, and Arno G. Motulsky

Oxford Monographs on Medical Genetics

Description

Since the first edition of this highly acclaimed text was published in 1992, much new knowledge has been gained about the role of genetic factors in common adult diseases, and we now have a better understanding of the molecular processes involved in genetic susceptibility and diseases mechanisms. The second edition fully incorporates these advances. The entire book has been updated and twelve new chapters have been added. Most of these chapters deal with diseases such as gallstones, osteoporosis, osteoarthritis, skin cancer, other common skin diseases, prostate cancer and migraine headaches that are seen by all physicians. Others address the genetic and molecular basis of spondylarthropathies, lupus, hemochromatosis, IgA deficiency, mental retardation, hearing loss, and the role of mitochondrial variation in adult diseases. Chapters on the evolution of human genetic disease and on animal models add important background on the omplexities of these diseases. Unique clinical applications of genetics to common diseases are covered in the additional new chapters on genetic counseling, pharmacogenetics, and the genetic consequences of modern therapeutics.

The Genetic Basis of Common Diseases

Second Edition

Edited by Richard A. King, Jerome I. Rotter, and Arno G. Motulsky

Oxford Monographs on Medical Genetics

Part I Approaches
1. Approach to Common Bases of Common Diseases, Richard A. King, Jerome I. Rotter, and Arno G. Motulsky
2. Molecular Genetics of Common Diseases, Jeffrey R. Smith, Thomas D. Gelehrter, Francis S. Collins (JS: Vanderbilt; TG: University of Michigan; FC: National Human Genome Research Institute)
3. Genetic Epidemiologic Methods, Stephen S. Rich and Thomas A. Sellers (SR:Wake Forest University School of Medicine; TS: Mayo Clinic and Mayo Foundation)
4. The Evolution of Human Genetic Diseases, Jared Diamond and Jerome I. Rotter (University of California, Los Angeles, both)
5. Animal Models of Complex Genetic Disease, Aldons J. Lusis, David West, and Richard C. Davis (AL, DW: University of California, Los Angeles; RD: Parke-Davis Pharmaceuticals)
6. Genetic Counseling: History, Risk Assessment, Strategies, and Ethical Considerations, Bonnie S. LeRoy and Ann P. Walker (BL: University of Minnesota; AW: University of California, Irvine)
Part II Cardiopulmonary Diseases
7. Genetics of COronary Atherosclerosis, Arno G. Motulsky and John D. Brunzell (University of Washington, both)
8. Hypertension, Steven C. Hunt, Paul N. Hopkins, Jean-Marc Lalouel (University of Utah, all)
9. Chronic Obstructive Pulmonary Disease, Francine Kauffmann and Florence Demenais (INSERM, both)
Part III Immunologic and Infectious Diseases
10. Genetics of Human Susceptibility to Infectious Diseases: Progress and Prospects, Ellen Buschman, Emil Skamene, and Erwin Schurr (EB, EmilS: McGill University Health Centre; ErwinS: Mc Gill Centre for the Study of Host Resistance)
11. Genetics of Asthma and Bronchial Hyperresponsiveness, Deborah A. Meyers, Denise G. Wiesch, and Eugene R. Bleecker (DM, EB: Wake Forest University School of Medicine; DW: National Institute of Allergy and Infectious Disease)
12. IgA Deficiency and Common Variable Immunodeficiency, Harry W. Schroeder, Jr. (University of Alabama at Birmingham)
Part IV Gastrointestinal Disorders
13. Peptic Ulcer and Gastritis, A.S. Pena (Vrije Universiteit Medical Center)
14. Lactase Deficiiency: Biological and Medical Aspects of the Adult Human Lactase Polymorphism, Edward J. Hollox and Dallas M. Swallow (EH: University Nottingham; Ds: University College London)
15. Inflammatory Bowel Disease.Huiying Yang and Krent D. Taylor (UCLA School of Medicine, both)
16. Gallstones, Beverly Paigen and Martin C. Carey (BP: The Jackson Laboratory; MC: Harvard Medical School)
17. Chronic Liver Disease, Albert J. Czaja (Mayo Clinic and Mayo Foundation)
18. Hereditary Hemochromatosis, Frances Busifield, G.J. Anderson, and L.W. Powell (The University of Queensland, Australia, all)
19. Gluten-Sensitive Enteropathy, Susan L. Neuhausen and John J. Zone (University of Utah, both)
Part V Endocrine Disorders
20. Thyroid Disease, Stefan K.G. Grebe (University of Outago, New Zealand)
21. Type 1 Diabetes Mellitus, Steven C. Elbein, Ken C. Chui, and M. Alan Permutt
22. Type 2 Diabetes Mellitus, Steven C. Elbein, Ken C. Chin, and M. Alan Permutt (SE: Univerity of Arkansas for Medical Sciencs; KC: UCLA School of Medicin; MP: Washington University School of Medicine)
23. Obesity, George Bray and Claude Bouchard (Louisiana State University, both)
24. Genetics of Osteoporosis, Tatiana Foroud, Michael J. Econs, and C. Conrad Johston, Jr. (Indiana University School of Medicine, all)
25. Hyperuricemia and Gout, Michael A. Becker (The University of Chicago Pritzker School of Medicine)
Part VI Genitourinary Disorders
26. Genetics of Gynecologic Disorders, Joe Leigh Simpson (Baylor College of Medicine)
27. Genetics of Infertility and Pregnancy Loss, Carole Ober, Marion S. Verp, Kenneth P. Roberts, and Jon L. Pryor (CO, MS: University of Chicago; KR, JP: University of Minnesota)
Part VII Rheumatologic Diseases
28. Immunology and Immunogenetics, Gerald T. Nepom and Henry A. Erlich (GN: University of Washington School of Medicine; HE: Roche Molecular Systems)
29. Rheumatoid Arthritis, Barbara Nepom and Richard A. King (BN: Virginia Mason Research Center, RK: University of Minnesota)
30. Seronegative Spondyloarthropathies, R. Hal Scofield (University of Oklahoma)
31. The Genetics of Systemic Lupus Erythematosus, Patrick M. Gafney, Richard A. King, and Timothy W. Behrens (University of Minnesota, all)
32. Genetic Basis of Primary Osteoarthritis, John Loughlin and Kay Chapman (University of Oxford, both)
33. Common Disorders of Connective Tissue, Reed E. Pyeritz (University of Pennsylvania School of Medicine)
Part VIII Cancer
34. Gastrointestinal Cancer, Randall W. Burt (University of Utah Health Sciences Center)
35. Breast Cancer, Katherine L. Nathanson and Barbara L. Weber (University of Pennsylvania, both)
36. Familial and Genetic Influences on Risk of Lung Cancer, Thomas A. Sellers and Ping Yang (Mayo Clinic, both)
37. Reproductive Organ Cancers, Maren T. Scheuner and Beth Y. Karlan (UCLA School of Medicine, both)
38. Skin Cancer, Allen E. Bale, Suzanne J. Brown, and William D. Posten (Yale University School of Meidicine, all)
39. Prostate Cancer, William B. Isaacs and Jianfeng Xu (WI: Johns Hopkins University; JX: Wake Forest University School of Medicine)
40. Hematologic Cancer, Marshall Horwitz (University of Washington School of Medicine)
Part IX Neuropsychiatric Disorders
41. Epilepsy, Magali Fernandez and Thomas D. Bird (MF: Ohio State University; TB University of Washington School of Medicine)
42. Genetic Basis of Multiple Sclerosis, Leena Peltonen, Janna Saarela, and Satu Kuokkanen (LP: UCLA School of Medicine; JS: University of Helsinki; SK: Columbia University)
43. The Genetics of Alzheimer Disease, Margaret A. Pericak-Vance and Jonathan L. Haines (MP-V: Duke University Medical Center; JH: Vanderbilt University Medical Center)
44. Genetics of Affective Disorders, Servilla D. Detera-Wadleigh and Lynn R. Goldin (SD-W: National Institute of Mental Health; LG: National Cancer Institute)
45. Schizophrenia, Ann E. Pulver, Godfrey Pearlson, John McGrath, Virginia Keyes Lasseter, Karen Swarts, and George Papadimitriou (GP: Athens University Medical School: All others: Johns Hopkins University)
46. Alcoholism, Dharam P. Agarwal (University of Hamburg)
47. Mental Retardation, W. Ted Brown (SUNY Downstate Medical Center)
48. Hereditary Hearing Loss, Rena Ellen Falk and Nathan Fischel-Ghodsian (UCLA School of Medicine, both)
49. Genetics of Migraine, Aarno Palotie, Robert Baloh, and Maija Wessman (AP, RB: UCLA School of Medicine; MW: University of Helsinki)
Part X Other Common Problems
50. Common Skin Disease, Virginia P. Sybert (University of Washington School of Medicine)
51. Genetic Modulation of Aging and Longevity, George M. Martin (University of Washington School of Medicine)
52. Mitochondrial Defects in Commons Diseases, Douglas C. Wallace and Marie T. Lott (Emory University, both)
53. Constitutional Chromosome Disorders in Adults, Georgia L. Wiesner, David B. Everman, and Suzanne B. Cassidy (GW: Case Western Reserve University; DE: Greenwood Genetic Center; SC: University of California, Irvine)
Part XI Therapy
54. Genetic Consequences of Modern Therapeutics: Iatrogenic Mutagensis, John J. Mulvihill, Sarah F. Whitton, and Patrick H. Horn (University of Oklahoma College of Medicine, all)
55. Pharmacogenetics, Ecogenetics, and Pharmacogenomics, Werner Kallow (University of Toronto)

The Genetic Basis of Common Diseases

Second Edition

Edited by Richard A. King, Jerome I. Rotter, and Arno G. Motulsky

Oxford Monographs on Medical Genetics

Reviews and Awards

From reviews of the first edition:

"The Genetic Basis of Common Diseases is an excellent compilation of current knowledge....I use this fine book daily and look forward to subsequent editions."--Journal of the American Medical Association

"Future generations of physicians may look back at the first edition of this book much the way we now percieve Osler's Principles and Practice of Medicine, initially published in 1892, as the first in a long line of episodic revisions that acquired many competitors along the way...this new work stands alone and is a worthy addition to the literature of internal medicine."--Annals of Internal Medicine

"The organizational aspects of the text make the information readily retrievable...This useful reference text is not only relevant to the student seeking a basic understanding of a particular disease, it is relevant to the physician through its discussion of treatments and to the genetic couselor through its presentation of genetic risk information for families."--International Journal of Experimental and Clinical Investigation

"This text follows the tradition of excellence of the Oxford Monographs in Medical Genetics."--Neuromuscular Disorders