The Bipolar Brain

Integrating Neuroimaging and Genetics

Edited by Stephen Strakowski

The first book to bring together leading experts in both genetics and neuroimaging
Provides a current review of these important fields.
Integrates genetic and neuroimaging leading to a new model for bipolar disorder as well as guidance for developing personalized approaches to the illness.

The Bipolar Brain

Integrating Neuroimaging and Genetics

Edited by Stephen Strakowski

Description

Bipolar disorder is one of the most common, and disabling, conditions affecting human kind. Each year, millions of individuals struggle with the effects of this illness. Although clinically well recognized for decades, if not centuries, the causes of this condition remain incompletely understood. However, in the past decade, significant technological advances in both neuroimaging and genetic research have revealed clues about the neurophysiological basis of bipolar illness. In this book, leading experts in neuroimaging and genetics discuss recent discoveries in bipolar disorder that identify both the structural, functional and chemical brain changes that seem to underlie this condition, as well as the possible genetic causes of these brain events. Based upon these discussions, the book then integrates these diverse considerations to develop a specific neurophysiological model of bipolar disorder. This model provides a resource to guide clinicians and patients as they struggle to understand this illness, as well as a guide for future investigations into the causes of bipolar disorder. With this guide in hand, this book will lead to a new framework for understanding bipolar disorder in order to, ultimately, develop improved therapies for affected individuals and novel strategies to prevent the onset in children at risk for this condition.

The Bipolar Brain

Integrating Neuroimaging and Genetics

Edited by Stephen Strakowski

Section I: How neuroimaging informs models of bipolar disorder.
Chapter 1. Brain imaging techniques and their application to bipolar disorder.
by Caleb M. Adler and Michael Cerullo
Chapter 2. Structural brain abnormalities in bipolar disorder.
by Koji Matsuo, Marsal Sanches, Paolo Brambilla, and Jair C. Soares
Chapter 3. Functional brain imaging in bipolar disorder
by Lori L. Altshuler and Jennifer Townsend
Chapter 4. Neurochemical and metabolic imaging in bipolar disorder
by Jieun E Kim, In Kyoon Lyoo, and Perry F Renshaw,
Chapter 5. Neuroimaging studies of bipolar disorder in youth.
by Manpreet K. Singh, Melissa P. DelBello, and Kiki D. Chang
Chapter 6. Neuroimaging difference between bipolar and unipolar depression.
by Amelia Versace, Jorge R.C. Almeida, and Mary L. Phillips
Chapter 7. Neuroimaging in bipolar disorder and schizophrenia.
by Heather Whalley, Jessika Sussman, and Andrew M. McIntosh
Section II: How genetic research informs models of bipolar disorder.
Chapter 8. Genetic techniques and their application to bipolar disorder.
by Aaron C. Vederman and Melvin G. McInnis
Chapter 9. General genetic findings in bipolar disorder.
by John I. Nurnberger, Jr.
Chapter 10. Genetics of bipolar disorder and schizophrenia.
by Michael E. Talkowski, Kodavali V Chowdari, Hader Mansour, K M Prasad, Joel Wood, and Vishwajit L Nimgaonkar
Chapter 11. Mitochondrial genetics and bipolar disorder.
by Hayley B. Clay, Satoshi Fuke, Tadafumi Kato, and Christine Konradi
Section III: Integration and future directions.
Chapter 12. Personalized medicine - can genetics and imaging inform treatment
by Roy H. Perlis and Hilary P. Blumberg
Chapter 13. Integration and consolidation - a neurophysiological model of bipolar disorder.
by Stephen M. Strakowski

The Bipolar Brain

Integrating Neuroimaging and Genetics

Edited by Stephen Strakowski

Author Information

Edited by Stephen Strakowski, The Dr. Stanley and Mickey Kaplan Professor and Chairman of Psychiatry, University of Cincinnati Medical Center

Dr. Strakowski was raised in a small town in northern Indiana. He developed an interest in neuroscience as an undergraduate at the University of Notre Dame, and this interest expanded to psychiatric conditions at Vanderbilt University School of Medicine. He refined his interests into bipolar disorder while training in psychiatry at McLean Hospital and Harvard University School of Medicine. He has developed his professional career at the University of Cincinnati College of Medicine, where he serves as Senior Associate Dean for Research.

Contributors:

Caleb M. Adler, MD , University of Cincinnati College of Medicine, Cincinnati, OH
Jorge R.C. Almeida, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA
Lori L. Altshuler, UCLA Mood Disorders Research Program, UCLA School of Medicine, Los Angeles, CA
Hayley B. Clay, Neuroscience Graduate Program, Vanderbilt University, Nashville, TN
Hilary P. Blumberg, Department of Psychiatry, Yale School of Medicine, New Haven, CT
Paolo Brambilla, Department of Experimental Clinical Medicine, Inter-University Center for Behavioral Neurosciences, University of Udine, IRCCS Scientific Institute "E. Medea", Udine, Italy
Michael A. Cerullo, MD, University of Cincinnati College of Medicine, Cincinnati, OH
Kiki D. Chang, MD, Stanford University School of Medicine, Stanford, CA
Kodavali V Chowdari, Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA
Melissa P. DelBello, MD, MS, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Satoshi Fuke, Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
Tadafumi Kato, Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan
Jieun E Kim, MD, PhD, Department of Brain and Cognitive Sciences, Ewha Womans University, Seoul, South Korea
Christine Konradi, Departments of Pharmacology and Psychiatry, Center for Molecular Neuroscience, Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN
In Kyoon Lyoo, MD, PhD, Departments of Psychiatry and Neuroscience, Seoul National University, Seoul, South Korea, The Brain Institute, The University of Utah, Salt Lake City, UT
Hader Mansour, Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA
Koji Matsuo, Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
Melvin G. McInnis, MD, University of Michigan, Ann Arbor, MI
Andrew M McIntosh, MD, MRCPsych, University of Edinburgh, Royal Edinburgh Hospital, Morningside Park, Edinburgh, UK
Vishwajit L Nimgaonkar, Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA
John I. Nurnberger, Jr., MD, PhD, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN
Roy H. Perlis, Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA
Mary L. Phillips, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA
K M Prasad, Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA
Perry F Renshaw, MD, PhD, The Brain Institute, The University of Utah, Salt Lake City, UT
Marsal Sanches, Department of Psychiatry and Behavioral Sciences, University of Texas Houston Medical School, Houston, TX
Manpreet K. Singh, MD, MS, Stanford University School of Medicine, Stanford, CA
Jair C. Soares, Department of Psychiatry and Behavioral Sciences, University of Texas Houston Medical School, Houston, TX
Stephen M. Strakowski, MD, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH
Jessika E Sussmann, MBChB, MRCPsych, University of Edinburgh, Royal Edinburgh Hospital, Morningside Park, Edinburgh, UK
Michael E. Talkowski, Center for Human Genetic Research, Massachusetts General Hospital, Department of Neurology, Harvard Medical School, Boston, MA, Program in Medical and Population Genetics, Broad Institute of Harvard and M.I.T, Cambridge, MA
Jennifer D. Townsend , UCLA Mood Disorders Research Program, UCLA School of Medicine, Los Angeles, CA
Aaron C. Vederman, PhD, University of Michigan, Ann Arbor, MI
Amelia Versace, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA
Heather C Whalley, PhD , University of Edinburgh, Royal Edinburgh Hospital, Morningside Park, Edinburgh, UK
Joel Wood, Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA