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Targeted Therapy for Cancer

Edited by Konstantinos Syrigos and Kevin Harrington

Targeted anti-cancer therapy in which a therapeutic agent is used specifically to target cancer cells has developed significantly over the last few years. Many of the recent developments are now beginning to move from the scientific realm into clinical practice. This book is a specialist reference text summarizing the burgeoning literature on these new types of targeted therapy for molecular oncologists, cancer researchers and those involved with clinical trials as well as providing a reference for oncologists who are beginning to use some of these therapies in everyday clinical practice.

Targeted Therapy for Cancer

Edited by Konstantinos Syrigos and Kevin Harrington

1. Section 1 The History of Targeted Therapy For Cancer, K.D. Bagshawe
2. Preclinical Models for the Study of Targeted Therapy, G. Rowlinson-Busza
3. Section 2 Monoclonal Antibody Targeting Therapy: An Overview, Roslyn J Francis & Richard HJ Begent
4. Antibody Directed Enzyme Prodrug Therapy (ADEPT), KN Syrigos & Kevin J Harrington
5. Monoclonal Antibody Targeted Radionuclide Therapy, Surinder K. Batra, Apollina Goel, Gabriela Pavlinkova & David Colcher
6. Combined External Beam Radiotherapy and Radioimmunotherapy, David Raben & Donald J. Buchsbaum
7. Section 3 Genetic Immunotherapy for Cancer, Hardev S Pandha
8. Targeting of Cancer Gene Therapy, Kevin J Harrington & Richard G. Vile
9. Targeted Genetic Prodrug Activation Therapy, Anne Rigg & Hardev Pandha
10. Antisense Therapy as a Targeted Modality, Justin Waters & David Cunningham
11. Dendritic Cells-Targeting the Anti-tumor Immune Response, Alan Melcher, Richard Vile, Andrew Bateman & Kevin Harrington
12. Cell Carriers for Cancer Gene Therapy: Bridging the gap between Targeted Vectors and Systemic Delivery?, Rosa Maria Diaz, Heung Chong & Richard Vile
13. Liposomal Targeting of Cytotoxic Drug, Kevin J Harrington & KN Syrigos
14. Targeting Blood Vessels In Vivo by Using Phage Display Libraries, Claudia Vidal, Marina Cardó-Vila, Johanna LahdenrantaWadih Arap & Renata Pasqualini
15. Section 4 Photodynamic Therapy, Michael R. Hamblin
16. Boron Neutron Capture Therapy: a chemically targeted radiation modality, Gerard M Morris & Jeffrey A. Coderre
17. Section 5 Cancer Immunotherapy Directed at Growth Factor Receptors: The ErbB/HER network as a prototype, Michael Sela, Bilha Schecheter & Yosef Yarden
18. Targeting the Metastatic Process, Lloyd A. Culp, Wen-Chang Lin, Nanette R. Kleinman, Priit Kogerman, Raymond Judware, Carson J. Miller & Julianne L. Holleran

Targeted Therapy for Cancer

Edited by Konstantinos Syrigos and Kevin Harrington

Author Information

Contributors:

Wadih Arap, Department of Genitourinary Medical Oncology and Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, USA

K. D. Bagshawe, CBE, Emeritus Professor of Medical Oncology, Imperial College of Science and Medicine, London, UK

Surinder K. Batra, Associate Professor, Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, USA

Andrew Bateman, Molecular Medicine Program, Mayo Clinic, Rochester, USA

Richard H. J. Begent, Professor of Medical Oncology, Cancer Research Campaign Targeting and Imaging Group, Department of Oncology, Royal Free and University College Medical School, London, UK

Donald J. Buchsbaum, Professor and Director, Division of Radiation Biology, Department of Radiation Oncology, University of Alabama at Birmingham, USA

Marina Cardó-Vila, Department of Genitourinary Medical Oncology and Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, USA

Heung Chong, Molecular Medicine Program, Mayo Clinic, Rochester, USA

Jeffrey A. Coderre, Medical Department, Brookhaven National Laboratory, New York, USA

David Colcher, Director, Radioimmunotherapy Research, Coulter Pharmaceutical, San Francisco, USA

Lloyd A. Culp, Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, USA

David Cunningham, Head of Gastrointestinal and Lymphoma Units, Royal Marsden Hospital, Sutton, UK

Rosa Maria Diaz, Molecular Medicine Program, Mayo Clinic, Rochester, USA

Roslyn J. Francis, Cancer Research Campaign Targeting and Imaging Group, Department of Oncology, Royal Free and University College Medical School, London, UK

Apollina Goel, Research Associate, Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, USA

Michael R. Hamblin, Assistant Professor of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston, USA

Kevin J. Harrington, Melucular Medicine Program, Mayo Clinic, Rochester, USA

Julianne L. Holleran, Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, USA

Raymond Judware, Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, USA

Nanette R. Kleinman, Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, USA

Priitt Kogerman, Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, USA

Johanna Lahdenranta, Department of Genitourinary Medical Oncology and Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, USA

Wen-Chang Lin, Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, USA

Alan Melcher, Molecular Medicine Program, Mayo Clinic, Rochester, USA

Carson J. Miller, Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, USA

Gerard M. Morris, Research Institute, University of Oxford, UK

Hardev S. Pandha, Honorary Simon Weinstock Senior Lecturer in Tumor Immunology, Department of Medical Oncology, St George's Hospital Medical School, London, UK

Renata Pasqualini, Department of Genitourinary Medical Oncology and Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, USA

Gabriela Pavlinkova, Instructor, Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, USA

David Raben, Assistant Professor, Department of Radiation Oncology, University of Colorado, Denver, USA

Anne Rigg, Department of Medicine, Royal Marsden Hospital, London, UK

G. Rowlinson-Busza, Antisoma Research Ltd, St George's Hospital Medical School, London, UK

Bilha Schecheter, Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel

Michael Sela, Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel

K. N. Syrigos, Consultant Medical Oncologist, Head, Oncology Unit, Athens Medical School, Sotiria General Hospital, Athens, Greece

Yosef Yarden, Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel

Claudia Vidal, Department of Genitourinary Medical Oncology and Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, USA

Richard G. Vile, Melucular Medicine Program, Mayo Clinic, Rochester, USA

Justin Waters, Department of Medicine, Royal Marsden Hospital, Sutton, Surrey, UK

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