Tailored Polymer Architectures for Pharmaceutical and Biomedical Applications

Edited by Carmen Scholz and Jorg Kressler

ACS Symposium Series

Presents the most recent research in polymer science, as it relates to biomedical and pharmaceutical uses.
Stems from a symposium held at national meeting of the American Chemical Society.

Tailored Polymer Architectures for Pharmaceutical and Biomedical Applications

Edited by Carmen Scholz and Jorg Kressler

Description

New synthetic polymers and polymer architectures contribute widely to the progress in pharmacy and biomedicine. This book consists of five sections that describe and discuss recent developments in biorelated polymers; specifically, the focus is on the following subject areas: i) Synthesis of new polymers for pharmacy and biomedicine, ii) Using polymers for modern therapeutic approaches, iii) Delivery of biomacromolecules, i.e., drugs as well as nucleic acids, iv) Polymers for tissue engineering, and v) Polymers for surfaces and sensors. All chapters were written by the world's leading scientists in their respective fields. Research presented in these chapters demonstrates that these new polymers, new polymer architectures, and new polymer conjugates are well suited for demanding applications in biomedical diagnostics and therapies. Modern approaches to drug delivery systems, new scaffolds for tissue engineering, and surfaces for sensors or antimicrobial activity are discussed in detail. Novel strategies in polymer synthesis are presented, as e.g. the functionalization of dendrimers or hyperbranched polymers, exploiting the possibilities of 'click' chemistry for the synthesis of well-defined block and graft copolymers or bioconjugation, and introducing environmentally responsive polymer moieties.
This book was inspired by the 11th Biorelated Polymer Symposium that was held at the 243rd ACS meeting in March of 2012. The 20 chapters of this book provide detailed information on cutting edge research in the field of polymer science for biomedical and pharmaceutical applications. They are intended not only for polymer scientists but also for engineers and scientists working with polymers in life sciences.

Tailored Polymer Architectures for Pharmaceutical and Biomedical Applications

Edited by Carmen Scholz and Jorg Kressler

ACS Symposium Series

Preface
Introduction
1. Introduction to Polymers in Today's Biomedical Realm
Carmen Scholz and Jörg Kressler
Polymers with New Designs
2. Polyether-Based Lipids Synthesized with an Epoxide Construction Kit:
Multivalent Architectures for Functional Liposomes
Sophie S. Müller, Carsten Dingels, Anna Maria Hofmann, and Holger Frey
3. Bioactive-Based Poly(anhydride-esters) and Blends for Controlled Drug
Delivery
R. Fogaça, M. A. Ouimet, L. H. Catalani, and K. E. Uhrich
4. Fatty Acid Modified Poly(glycerol adipate) - Polymeric Analogues of
Glycerides
T. Naolou, V. M. Weiss, D. Conrad, K. Busse, K. Mäder, and J. Kressler
5. Poly(oxazoline) Block Copolymers for Biomedical Applications
Michael J. Isaacman and Luke Theogarajan
6. Investigating the Secondary Structure of Oligomeric Poly(amino acid)s
David Ulkoski, Tracy Armstrong, and Carmen Scholz
7. Polymeric Micelles Stabilized by Electrostatic Interactions for Drug
Delivery
Yuichi Ohya
Modern Therapies
8. Combating HIV-1 Entry and Fusion with Peptide-Synthetic Polymer
Conjugates
Maarten Danial and Harm-Anton Klok
9. Cancer Stem Cells: Potential Target For Anti-Cancer Nanomedicines
Yan Zhou, Jiyuan Yang, and Jindrich Kopecek
10. Enhanced Delivery of Polymer Therapeutics to Solid Tumors
Adam J. Gormley, Nate Larson, and Hamidreza Ghandehari
Delivery of Biomacromolecules
11. Fine-Tuning of Repeating Aminoethyelene Units in Poly(aspartamide) Side
Chains for Enhanced siRNA Delivery
Kanjiro Miyata, R. James Christie, Tomoya Suma, Hiroyasu Takemoto,
Hirokuni Uchida, Nobuhiro Nishiyama, and Kazunori Kataoka
12. Dendrimer-Based RNA Interference Delivery for Cancer Therapy
Leyuan Xu, W. Andrew Yeudall, and Hu Yang
13. Challenges for PEGylated Proteins and Alternative Half-Life Extension
Technologies Based on Biodegradable Polymers
Ahmed Besheer, Robert Liebner, Martin Meyer, and Gerhard Winter
14. Thermoresponsive Polymers with Functional Groups Selected for
Pharmaceutical and Biomedical Applications
Naohiko Shimada and Atsushi Maruyama
Tissue Engineering
15. Biomaterial-Induced Angiogenesis To Address Peripheral Vascular Disease:
The Application of Sphere Templated Hydrogels
Dale Terasaki, Michael Sobel, Colleen Irvin, Errol Wijelath, and Buddy D. Ratner
16. Novel Cellulose Derivatives with Mitogenic and Osteogenic Activity
Kai Zhang, Dieter Peschel, Steffen Fischer, and Thomas Groth
17. Tailoring Silk-Based Matrices for Tissue Regeneration
A. Motta, C. Foss, and C. Migliaresi
Surfaces and Sensors
18. Health and Safety via Surface Modification of Polyurethanes
Kenneth J. Wynne, Pinar Kurt, Kennard Brunson, Asima Chakravorty, Murari Gupta,
Wei Zhang, Lynn Wood, and Dennis E. Ohman
19. Antimicrobial Polymers: Molecular Design as Synthetic Mimics of
Host-Defense Peptides
Edmund F. Palermo, Satyavani Vemparala, and Kenichi Kuroda
20. Discrimination of Influenza Virus Strains and Super High Sensitive
Detection of Viruses Using Sugar Chip and Sugar-Chain Immobilized Gold
Nanoparticles
Yasuo Suda, Xu Zhang, Yuko Takahashi, Risa Yokoyama, Mami Nagatomo,
Kazue Aoyama, Toshiomi Okuno, Shigeru Saito, Saeko Morikawa, Satoshi Hiroi,
Tetsuo Kase, Naoki Murakami, Junichiro Nishi, and Masahiro Wakao
Editors' Biographies
Indexes
Author Index
Subject Index

Tailored Polymer Architectures for Pharmaceutical and Biomedical Applications

Edited by Carmen Scholz and Jorg Kressler

ACS Symposium Series

Author Information

Edited by Carmen Scholz, Professor of Chemistry, University of Alabama in Huntsville, and Jorg Kressler, Professor of Physical Chemistry, The Martin Luther University Halle-Wittenberg

Carmen Scholz is Professor of Chemistry at the University of Alabama in Huntsville. Jorg Kressler is Professor of Physical Chemistry at The Martin Luther University Halle-Wittenberg.