Renal Cell Carcinoma

Edited by Nizar M. Tannir

Chapters on RCC therapies including: surgical approaches, adjuvant and neoadjuvant, cytoreductive nephrectomy and systemic therapy, immunotherapy, and targeted therapies
Chapter on the management of complications from RCC therapies
Chapters on supportive and integrative care for RCC patients

Renal Cell Carcinoma

Edited by Nizar M. Tannir

Description

While patients with metastatic renal cell carcinoma (mRCC) are now living longer with improved quality of life, the success of novel therapies for mRCC has created challenges for practicing oncologists. Many patients who initially respond to targeted therapies ultimately develop progressive disease due to acquired resistance to these agents. Additionally, some patients do not respond at all to any of the currently approved targeted agents, underscoring the need for continued and concerted efforts to identify other relevant targets and pursue alternative therapeutic strategies. Part of the Oxford American Oncology Library, Renal Cell Carcinoma is a concise handbook that addresses the complex management of patients with mRCC. The book begins with a review of the epidemiology, pathology, and biology of renal cell carcinoma followed by chapters on specific targeted therapies and managing complications. The final chapters discuss supportive and integrative care and emerging therapies.

Renal Cell Carcinoma

Edited by Nizar M. Tannir

1. Epidemiology of Renal Cell Carcinoma
2. Pathology of Renal Cell Carcinoma
3. Biology of Renal Cell Carcinoma
4. Inherited Renal Cell Cancers
5. Interventional Radiology Procedures in Renal Cell Carcinoma
6. Management of Small Renal Masses and Early-Stage Renal Cell Carcinoma
7. Staging and Surgical Management of Locally Advanced Renal Cell Carcinoma and the Role of Adjuvant and Neoadjuvant Therapy
8. Integration of Targeted Therapy with Cytoreductive Nephrectomy and Metastasectomy in the Management of Metastatic Renal Cell Carcinoma
9. Immunotherapeutic Approaches for Metastatic Conventional-Type Renal Cell Carcinoma
10. Targeted Therapies for Metastatic Conventional-Type Renal Cell Carcinoma
11. Systemic Therapies for Metastatic Renal Cell Carcinoma of Variant Histology
12. Prognostic and Predictive Biomarkers in Renal Cell Carcinoma
13. Management of Complications of Targeted Therapies for Metastatic Renal Cell Carcinoma
14. The Role of Traditional and Stereotactic Radiation in Metastatic Renal Cell Carcinoma
15. Supportive Care in Advanced Renal Cell Carcinoma
16. Integrative Medicine in the Management of Renal Cell Carcinoma
17. Emerging Therapies and Future Directions in Renal Cell Carcinoma

Renal Cell Carcinoma

Edited by Nizar M. Tannir

Author Information

Edited by Nizar M. Tannir, Associate Professor, and Deputy Department Chair, Department of Genitourinary Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center

Associate Professor, and Deputy Department Chair, Department of Genitourinary Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas

Contributors:

Michael B. Atkins, MD
Department of Oncology
Georgetown-Lombardi Comprehensive Cancer Center
Division of Hematology/Oncology
Medstar Georgetown University Hospital
Washington DC

Bradley Atkinson, PharmD, BCPS
Manager of Clinical Pharmacy Services
Department of Genitourinary Medical Oncology
The University of Texas MD Anderson Cancer Center
Houston, Texas

Diana Cauley, PharmD, BCOP
Clinical Pharmacy Specialist
Department Genitourinary Medical Oncology
The University of Texas MD Anderson Cancer Center
Houston, Texas

Alejandro Chaoul, PhD
Assistant Professor
Director of Education, Integrative Medicine Program
General Oncology
The University of Texas MD Anderson Cancer Center
Houston, Texas

David D. Chism, MD, MS
Hematology/Oncology Fellow
University of North Carolina, Chapel Hill
Lineberger Cancer Center
Chapel Hill, North Carolina

Seungtaek Choi
Assistant Professor
Department of Radiation Oncology
The University of Texas MD Anderson Cancer Center
Houston, Texas

Toni K. Choueiri, MD
Division of Medical Oncology
Dana Farber Cancer Institute
Brigham & Women's Hospital
Boston, Massachusetts

Wong-Ho Chow, PhD
Department of Epidemiology
The University of Texas MD Anderson Cancer Center
Houston, Texas

Lorenzo Cohen, PhD
Professor of Oncology
Director of Integrative Medicine Program
The University of Texas MD Anderson Cancer Center
Houston, Texas

Ruhee Dere, PhD
Center for Translational Cancer Research
Institute of Biosciences and Technology
Texas A&M Health Science Center
Houston, Texas

Tim Eisen BSc, MB BChir, PhD, FRCP
Professor of Medical Oncology
Department of Oncology
Cambridge Cancer Trials Centre

M. Kay Garcia, DrPH, MSN, LAc
Acupuncturist
General Oncology
The University of Texas MD Anderson Cancer Center
Houston, Texas

Bishoy A. Gayed, MD
Assistant Instructor of Urology
University of Texas Southwestern Medical Center
Dallas, Texas

Amol J. Ghia
Assistant Professor
Department of Radiation Oncology
The University of Texas MD Anderson Cancer Center
Houston, Texas

Jian Gu, PhD
Department of Epidemiology
The University of Texas MD Anderson Cancer Center
Houston, Texas

Anasuya Gunturi , MD PhD
Hematology/Oncology Fellow
Department of Medicine
Beth Israel Deaconess Medical Center
Boston, Massachusetts

Thai H. Ho, MD, PhD
Division of Hematology and Oncology
Mayo Clinic
Scottsdale, Arizona

Eric Jonasch, MD
Associate Professor of Genitourinary Medical Oncology
The University of Texas MD Anderson Cancer Center
Houston, Texas

Sarathi Kalra, MD
Department of Genitourinary Medical Oncology
The University of Texas MD Anderson Cancer Center
Houston, Texas

Jose A. Karam, MD
Assistant Professor of Urology
The University of Texas MD Anderson Cancer Center
Houston, Texas

Dae Y. Kim, MD, PhD
Urologic Oncology Fellow
Department of Urology
The University of Texas MD Anderson Cancer Center
Houston, Texas

Richard Lee, MD
Assistant Professor of Oncology
Medical Director of Integrative Medicine Center
The University of Texas MD Anderson Cancer Center
Houston, Texas

Gabriel Lopez, MD
Assistant Professor of Oncology
The University of Texas MD Anderson Cancer Center
Houston, Texas

Vitaly Margulis, MD
Assistant Professor of Urology
University of Texas Southwestern Medical Center
Dallas, Texas
Surena F. Matin, MD, FACS
Professor of Urology
Division of Surgery
The University of Texas MD Anderson Cancer Center
Houston, Texas

David F. McDermott, MD
Associate Professor of Medicine
Harvard Medical School
Department of Hematology/Oncology
Beth Israel Deaconess Medical Center
Boston, Massachusetts

Sumanta K. Pal, MD
Department of Medical Oncology & Experimental Therapeutics
City of Hope Cancer Center
Duarte, California

George K. Philips, MB,BS
Department of Oncology
Georgetown-Lombardi Comprehensive Cancer Center
Division of Hematology/Oncology
Medstar Georgetown University Hospital
Washington DC

Priya Rao, MD
Assistant Professor of Pathology
Department of Pathology
The University of Texas MD Anderson Cancer Center
Houston, Texas

W. Kimryn Rathmell, MD, PhD
Associate Professor of Medicine
Division of Hematology and Oncology
University of North Carolina, Chapel Hill
Lineberger Cancer Center
Chapel Hill, North Carolina

Sharjeel H. Sabir, MD
Assistant Professor of Interventional Radiology
The University of Texas MD Anderson Cancer Center
Houston, Texas

Ferdinandos Skoulidis MD, PhD, MRCP
Academic Clinical Lecturer in Medical Oncology
Department of Oncology
University of Cambridge
Cambridge, United Kingdom

Xiang Shu, MS
Department of Epidemiology
The University of Texas MD Anderson Cancer Center
Houston, Texas

Alda L. Tam, MD, FRCPC, MBA
Assistant Professor of Diagnostic Radiology
The University of Texas MD Anderson Cancer Center
Houston, Texas

Pheroze Tamboli, MD
Professor of Pathology
The University of Texas M. D. Anderson Cancer Center
Houston, Texas

Cheryl L. Walker, PhD
Center for Translational Cancer Research
Institute of Biosciences and Technology
Texas A&M Health Science Center
Houston, Texas

Christopher G. Wood, MD, FACS
Professor and Deputy Chairman of Urology
The University of Texas MD Anderson Cancer Cent
Houston, Texas

Xifeng Wu, MD, PhD
Professor and Department Chair of Epidemiology
The University of Texas MD Anderson Cancer Center
Houston, Texas

Sriram Yennurajalingam, MD, MS
Associate Professor of Medicine
Department of Palliative Care and Rehabilitation Medicine
University of Texas, MD Anderson Cancer Center
Houston, Texas