Journals Higher Education

$135.00

Hardcover

Published: 31 August 2018

285 Pages | 48 color & 9 B&W

7" x 10" inches

ISBN: 9781621822219


Bookseller Code (06)

Ras and Cancer in the 21st Century

Edited by Linda Van Aelst, Julian Downward, and Frank McCormick

A Cold Spring Harbor Laboratory Press Publication

Perspectives CSHL

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the recent progress that has been made in understanding Ras biology, how Ras activation leads to tumorigenesis, and ways in which oncogenic Ras signaling may be targeted therapeutically. The contributors review the biochemical characteristics of the different Ras isoforms (HRAS, KRAS, and NRAS), their main effectors and signaling pathways, and the mutations that lead to their constitutive activation. Recent work showing that some Ras oncoproteins may be effectively inhibited by small molecules is covered, as is work on alternative targets (e.g., enzymes that catalyze posttranslational modifications of Ras) and inhibitors (e.g., nucleic acids).

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