Radiotherapy in practice - radioisotope therapy

Edited by Peter J Hoskin

Radiotherapy in Practice

Provides a background in the physics and developmental biology that underpins the use of radioisotopes
Emphasizes practical guidance, making it useful in the clinical setting
Includes site and disease specific chapters, covering the most common use of this treatment modality
Radioisotope therapy is currently an active area of research

Radiotherapy in practice - radioisotope therapy

Edited by Peter J Hoskin

Description

Radioisotope therapy is an internal form of radiation used to treat cancer; it may be administered orally or intravenously and represents the nearest treatment option to the 'magic bullet', specifically targeting sites of disease whilst sparing surrounding normal tissues. Radioisotope therapy has an important role to play in modern medicine, particularly in the treatment of thyroid disease, neuroendocrine tumours, bone metastasis and non-Hodgkin's lymphoma. It is found in both the diagnostic setting and in therapy, but recently there has been a renaissance in the application of radioisotope unsealed sources in therapeutic indications. It is an active area of research, with the quest for new compounds that will be specific for therapeutic targets.

This book is an essential, practical guide to the use of radioisotope therapy, and also includes the background and developmental biology which underpins its use. Individual tumours and diseases are explored, with specific focus given to radioisotope treatment options. The barriers to radioisotope therapy, such as ease of access, acquisition of radioisotopes, radiation protection regulations, and cost are also discussed.

ABOUT THE SERIES
Radiotherapy remains the major non-surgical treatment modality for the management of malignant disease, with over 50% of patients receiving treatment at some time during the management of their malignant disease. It is based on the application of the principles of applied physics, radiobiology, and tumour biology to clinical practice. Each volume in this series takes the reader through the basic principles of different types of radiotherapy, and then develops these by individual sites. This series of practical handbooks are aimed at physicians both training and practising in radiotherapy, as well as medical physicists, dosimetrists, radiographers and senior nurses.

Radiotherapy in practice - radioisotope therapy

Edited by Peter J Hoskin

Radiotherapy in Practice

1:Physics principles in the clinical use of radioisotopes, B Pratt and S Evans
2:Antibody directed radioisotope therapy, J L J Dearling and R B Pedley
3:Radiotherapy for benign thyroid disease: use of I131, Hyer and C Harmer
4:Malignant thyroid disease: use of I131, S E M Clarke and U Mallick
5:Neuroendocrine tumours, J Bomanji and G Gnanasegaran
6:Radioisotope therapy for metastatic bone disease, P Hoskin
7:Radioimmunotherapy for lymphoma, T Illidge and Y Du
8:Other therapeutic use of radioisotopes, P Hoskin
9:Radioprotection and regulatory aspects of radioisotope therapy, S Evans and B Pratt

Radiotherapy in practice - radioisotope therapy

Edited by Peter J Hoskin

Radiotherapy in Practice

Author Information

Edited by Peter J Hoskin, Professor of Clinical Oncology, University College London, and Mount Vernon Hospital, Rickmansworth Road, Northwood, Middlesex, UK

Contributors:

Jamshed Bomanji, Consultant in Nuclear Medicine, Middlesex Hospital, London, UK
Sue Clarke, Consultant in Nuclear Medicine, King's College Hospital, London, UK
Yong Du, Specialist Registrar Physician, Institute of Nuclear Medicine, University College London, UK
Jason L J Dearling, Cancer Research UK Targeting and Imaging Group, Department of Oncology, Royal Free and UCL Medical School, London, UK
Stephen Evans, Head of Radiological Physics and Radiation Protection Advisor, Royal Marsden NHS Foundation Trust, London, UK
G Gnanasegaran, Specialist Registrar in Nuclear Medicine, Guy's Hospital, London, UK
Clive L Harmer, Head of Thyroid Unit and Consultant in Clinical Oncology, Royal Marsden Hospital, London, UK
Peter J Hoskin, Professor of Clinical Oncology, Mount Vernon Hospital, Middlesex, UK
Steve L Hyer, Consultant Endocrinologist, St Hellier Hospital, Carshalton, UK
Tim Illidge, Professor of Clinical Oncology, Christie Hospital, Manchester, UK
Ujjal Mallick, Consultant Clinical Oncologist, The Northern Centre for Cancer Treatment, Newcastle-upon-Tyne, UK
R Barbara Pedley, Reader and Group Head: Tumor Biology, Department of Oncology, Royal Free and University College Medical School, Royal Free Hospital, London, UK
Brenda Pratt, Principal Radioisotope Protection Physicist, Royal Marsden NHS Foundation Trust, London, UK

Radiotherapy in practice - radioisotope therapy

Edited by Peter J Hoskin

Radiotherapy in Practice

Reviews and Awards

"...an essential, practical guide to the use of radioisotope therapy, and also includes the background and developmental biology which underpins its use. Individual tumours and diseases are explored, with specific focus given to radioiodine (I131) and monoclonal antibodies as treatment options. The barriers to radioisotope therapy, such as ease of access, acquisition of radioisotopes, radiation protection, and cost are also discussed." - Anticancer Research