Radiotherapy and the Cancers of Children, Teenagers, and Young Adults

Edited by Tom Boterberg, Karin Dieckmann, and Mark Gaze

Radiotherapy in Practice

Presents a comprehensive, practical, and evidence-based guide to radiotherapy in the management of children and young people with cancer
Provides guidance on the range of radiotherapy options available including image-guided and intensity modulated radiotherapy, brachytherapy, proton beam therapy, and molecular radiotherapy
Emphasizes a multi-disciplinary team approach, and considers the wider services needed for treating young people, such as anaesthesia and play specialist support
Includes case histories to demonstrate in practice the various methods explored
Clear and easy to use, with over 75 full-colour illustrations and a carefully selected further reading list on each topic

Radiotherapy and the Cancers of Children, Teenagers, and Young Adults

Edited by Tom Boterberg, Karin Dieckmann, and Mark Gaze

Description

This new volume in the Radiotherapy in Practice series provides a comprehensive and evidence-based guide to radiotherapy in the management of children and young people with cancer.

It explains the roles of the various modalities of treatment available, including image-guided and intensity modulated radiotherapy, brachytherapy, proton beam therapy, and molecular radiotherapy, and aids selection of the most appropriate technique in different situations. Each cancer type in children is explored, including diagnostic investigations, risk stratification, multi-modality approaches to treatment, and decision making with regard to radiotherapy. Specific guidance is given for the planning and prescription of radiotherapy for infants, children, and teenagers. The authors also identify the need for specialist paediatric radiotherapy service provision, and the wider requirements for radiotherapy in children, including consent, immobilisation, anaesthesia, multi-professional team working, and play specialist support.

With over 75 colour illustrations, case histories to demonstrate the various approaches, and a carefully selected guide to further reading on each topic, this practical volume will be a valuable resource for physicians and trainees in radiotherapy and clinical oncology, and to nurses, radiographers and other allied health professionals who come into contact with young patients receiving radiotherapy.

ABOUT THE SERIES
Radiotherapy remains the major non-surgical treatment modality for the management of malignant disease. It is based on the application of the principles of applied physics, radiobiology, and tumour biology to clinical practice. Each volume in the series takes the reader through the basic principles of the use of ionizing radiation and then develops this by individual sites. This series of practical handbooks is aimed at physicians both training and practising in radiotherapy, as well as medical physics, dosimetrists, radiographers, and senior nurses.

Radiotherapy and the Cancers of Children, Teenagers, and Young Adults

Edited by Tom Boterberg, Karin Dieckmann, and Mark Gaze

Radiotherapy in Practice

Section 1: Generic issues in childhood and teenage and young adult cancer
1:Cancers in children, teenagers and young adults, Tom Boterberg, Karin Dieckmann, and Mark Gaze
2:Cancer services for children, teenagers and young adults, Tom Boterberg, Karin Dieckmann, Helen Woodman and Mark Gaze
3:Diagnosis, risk stratification, therapeutic choices, Tom Boterberg, Edmund Cheesman, Felice D'Arco, Karin Dieckmann, Mark Gaze, Paul Humphries, Anna Kelsey, Øysten Olsen, Bruce Poppe, Derek Roebuck, Chitra Sethuraman, Frank Speleman and Gordan Vujanic
Section 2: Generic aspects of radiotherapy in this age range
4:Radiotherapy preparation and treatment, Ronda Alexander, Tom Boterberg, Karin Dieckmann, Mark Gaze, Hannah King and Helen Woodman
5:Aftercare, Tom Boterberg, Yen-Ch'ing Chang, Karin Dieckmann, Mark Gaze and Helen Woodman
Section 3: Specifics of each disease type
6:Central nervous system, Thankamma Ajithkumar, Tom Boterberg, Edmund Cheesman, Felice D'Arco, Karin Dieckmann, Mark Gaze, Gail Horan, Geert Janssens, Rolf-Dieter Kortmann, Nicky Thorp and Gillian Whitfield
7:Extracranial solid tumours, Thankamma Ajithkumar, Tom Boterberg, Victoria Castel, Karin Dieckmann, Jennifer Gains, Mark Gaze, Gail Horan, Paul Humphries, Anna Kelsey, Henry Mandeville, Øystein Olsen, Andrew D. J. Pearson, Derek Roebuck, Daniel Saunders and Chitra Sethuraman
8:Lymphoid and haematological malignancy and related conditions, Tom Boterberg, Yen-Ch'ing Chang, Karin Dieckmann, Eve Gallop-Evans, Mark Gaze, Paul Humphries, Anna Kelsey, Øystein Olsen, Derek Roebuck, and Chitra Sethuraman

Radiotherapy and the Cancers of Children, Teenagers, and Young Adults

Edited by Tom Boterberg, Karin Dieckmann, and Mark Gaze

Radiotherapy in Practice

Author Information

Edited by Tom Boterberg, Radiation Oncologist, Department of Radiation Oncology, Ghent University Hospital, Belgium, Karin Dieckmann, Radiation Therapy Professor, Medical University Vienna, Austria, and Mark Gaze, Consultant Clinical Oncologist, Department of Oncology, University College London Hospitals NHS Foundation Trust, UK

Tom Boterberg graduated as an MD in 1994 at Ghent University. After one year of residency in radiation oncology, he worked for 4 years at the Laboratory of Experimental Cancer Research on the biology of the invasive and metastatic behaviour of breast cancer cells. He obtained his PhD in 2000. Afterwards he continued his training in radiation oncology and in 2001 he obtained his Board Certificate in Radiation Oncology. Since 2001 he works as a staff member at the Department of Radiation Oncology at Ghent University Hospital. He is especially interested in paediatricradiotherapy. He is actively involved in the radiotherapy committees of SIOPEN (neuroblastoma) and EpSSG (rhabdomyosarcoma). He is boardmember of SIOPE and chairs the QUARTET project on quality assurance in paediatric radiotherapy. He is author or co-author of over 100 articlesin peer-reviewed journals. His other interests are haematology, neuro-oncology, intra-operative brachytherapy and radioprotection.

Karin Dieckmann graduated from the University of Hamburg,and was trained in Radiology and Radio-oncology at the University of Goettingen and at the Charité Berlin, all in Germany. Since 1994 she has worked at the Department of Radio-oncology of the Medical University Vienna and undertakes research in stereotactic radiosurgery and paediatric radiation oncology. She is especially interested in paediatic radiotherapy and is actively involved in the European Paediatric Hodgkin studies (EuroNetPhL C1 and C2), SIOPEN neuroblastoma study, and the European Brain Tumour Group. For many years she has been a faculty member of the ESTRO teaching courses,and is now chair of the ESTRO paediatric oncology teaching course. She is chair of the German Paediatric Radio-oncology Group (APRO). She is author and co-author of radiation oncology books, and of more than 150 articles in peer-reviewed journals.

Mark Gaze qualified from Saint Bartholomew's Hospital, London. He trained in clinical oncology in Edinburgh and Glasgow and undertook research at the universities there. He is a consultant clinical oncologist at University College London Hospitals and Great Ormond Street Hospital for Children NHS Foundation Trusts and has developed a highly specialised practice in paediatric and molecular radiotherapy. He has an interest in both neuroblastoma and rhabdomyosarcoma, and is a member of SIOPEN and EpSSG, chairing their radiotherapy committees in the past, and the National Cancer Research Institute's Neuroblastoma Group. Wider interests in paediatric oncology and medicine in general led him to chair the Children's Cancer and Leukaemia Group, and to have been a member of council for both the Royal College of Physicians of Edinburgh and the Royal College of Radiologists. He is a member of the Administration of Radioactive Substances Advisory Committee for the Department of Health and Social Care.

Contributors:

Thankamma Ajithkumar
Consultant in Clinical Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
Rhonda Alexander
Senior Play Specialist, Department of Oncology, University College London Hospitals NHS Foundation Trust, London, UK
Tom Boterberg
Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium
Victoria Castel
Pediatric Oncology Unit, La Fe University Hospital, Valencia, Spain
Edmund Cheesman
Consultant Paediatric Histopathologist, Manchester University NHS Foundation Trust, Manchester, UK
Yen-Ch'ing Chang
Consultant Clinical Oncologist, Department of Oncology, University College London Hospitals NHS Foundation Trust, London, UK
Felice D'Arco
Consultant Paediatric Neuroradiologist, Great Ormond Street Hospital, for Children NHS Foundation Trust, London, UK
Karin Dieckmann
Radiation Therapy Professor, Medical University Vienna, Vienna, Austria
Jennifer Gains
Consultant Clinical Oncologist, Department of Oncology, University College London Hospitals NHS Foundation Trust, London, UK
Eve Gallop-Evans
Consultant Clinical Oncologist and Director of Clinical Trials Unit, Velindre Cancer Centre, Cardiff, UK
Mark Gaze
Consultant Clinical Oncologist, Department of Oncology, University College London Hospitals NHS Foundation Trust, London, UK
Gail Horan
Consultant Clinical Oncologist, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
Paul Humphries
Consultant Radiologist, University College London Hospitals NHS Foundation Trust, London, UK
Geert Janssens
Radiation Oncologist, Department of Radiotherapy, University Medical Centre Utrecht, Utrecht, the Netherlands
Anna Kelsey
Consultant Peadiatric Histopathologist, Manchester University NHS Foundation Trust, Manchester, UK
Hannah King
Consultant Paediatric Anaesthetist, Department of Anaesthesia, Nottingham University Hospitals NHS Trust, Nottingham, UK
Rolf-Dieter Kortmann
Head of Department, Radiation Therapy, University of Leipzig, Leipzig, Germany
Henry Mandeville
Consultant Clinical Oncologist, The Royal Marsden NHS Foundation Trust, London, UK
Øysten Olsen
Consultant Paediatric Radiologist, Great Ormond Street Hospital, for Children NHS Foundation Trust, London, UK
Andrew D. J. Pearson
Former Professor of Paediatric Oncology, Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, UK
Bruce Poppe
Clinical Geneticist and Head of Department, Centre for Medical Genetics, Ghent University, Ghent, Belgium
Derek Roebuck
Professor of Paediatric Radiology, University of Western Australia and Perth Children's Hospital, Perth, Australia
Daniel Saunders
Consultant Clinical Oncologist, The Christie NHS Foundation Trust, Manchester, UK
Chitra Sethuraman
Consultant Paediatric, Placental and Perinatal Histopathologist, Manchester University NHS Foundation Trust, Manchester, UK
Frank Speleman
Principal Investigator - Lab for Paediatric Oncogenomics, Centre for Medical Genetics, Ghent University, Ghent, Belgium
Nicky Thorp
Consultant Clinical Oncologist, Clatterbridge Cancer Centre, Birkenhead, UK
Gordan Vujanic
Professor Gordan Vujanic, Senior Attending Physician in Pediatric Pathology, Sidra Medicine, Qatar
Gillian Whitfield
Consultant Clinical Oncologist, The Christie NHS Foundation Trust, Manchester, UK
Helen Woodman
Clinical Nurse Specialist, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK