Psychiatric Genetics

A Primer for Clinical and Basic Scientists

Edited by Thomas Schulze and Francis McMahon

Offers a comprehensive overview of psychiatric genetics in concise, easy-to-follow language
Each chapter begins with a list of "take home" points that summarizes content
Provides suggestions for further reading on each topic

Psychiatric Genetics

A Primer for Clinical and Basic Scientists

Edited by Thomas Schulze and Francis McMahon

Description

Psychiatrists and other mental health professionals are increasingly confronted with questions about the genetics of psychiatric illness, and the clinical applications of new genetic findings. Psychiatric Genetics: A Primer for Clinical and Basic Scientists addresses these questions through a straightforward introduction to the essentials of psychiatric genetics, complementing more comprehensive textbooks that may seem overwhelming for those new to the field. Written and edited by leaders in the field and the International Society of Psychiatric Genetics (ISPG), the book covers basic epidemiology, recruitment for human studies, phenotyping strategies, formal genetic and molecular genetic studies, statistical genetics, bioinformatics and genomics, pharmacogenetics, the most relevant animal models, and biobanking. Each chapter begins with a list of "take home" points that summarizes content, followed by a brief overview of current knowledge and suggestions for further reading. This Primer is ideal for medical students, psychiatric residents, psychiatrists, and basic neuroscience researchers who are interested in learning about the key concepts and recent advances in the exciting field of psychiatric genetics.

Psychiatric Genetics

A Primer for Clinical and Basic Scientists

Edited by Thomas Schulze and Francis McMahon

Chapter 1: Contribution of Epidemiology to Our Understanding of Psychiatric Genetics
Alison K. Merikangas and Kathleen R. Merikangas
Chapter 2: Recruitment of Human Subjects: An overview of techniques and methods used in psychiatric and other clinical studies
Layla Kassem
Chapter 3: Basic molecular genetics concepts and tools: from SNPs to chips
Sevilla D Detera-Wadleigh, Nirmala Akula, and Liping Hou
Chapter 4: Statistical genetics: Genome-wide studies
Till F.M. Andlauer, Bertram Muller-Myhsok, and Stephan Ripke
Chapter 5: Human Linkage and Association Analysis
John P. Rice
Chapter 6: The role of copy number variation in psychiatric disorders
Elliott Rees and George Kirov
Chapter 7: Pharmacogenomics & Precision Psychiatry
Julia C. Stingl and Gonzalo Laje
Chapter 8. Endophenotypes
David C. Glahn, Laura Almasy, and John Blangero
Chapter 9: Imaging Genetics
Luanna Dixson, Heike Tost, and Andreas Meyer-Lindenberg
Chapter 10: Bioinformatics in psychiatric genetics
Nikola S. Mueller, Ivan Kondofersky, Gokcen Eraslan, Karolina Worf, and Fabian J. Theis
Chapter 11: Epigenomic Exploration of the Human Brain
Tobias B. Halene, Gregor Hasler, Amanda Mitchell, and Schahram Akbarian
Chapter 12: Epigenetics in Psychiatry
Subha Subramanian and James B. Potash
Chapter 13: Next-generation sequencing in genetic studies of psychiatric disorders
Shweta Ramdas and Jun Z. Li
Chapter 14: Animal Models
Tadafumi Kato
Chapter 15: Biobanking of Human Induced Pluripotent Stem Cells for Psychiatric Research
Jennifer C. Moore, Michael Sheldon, and Jay A. Tischfield

Psychiatric Genetics

A Primer for Clinical and Basic Scientists

Edited by Thomas Schulze and Francis McMahon

Author Information

Edited by Thomas Schulze, Professor of Psychiatric Genetics, University of Gottingen, and Edited by Francis McMahon, Chief, Human Genetics Branch, National Institute of Mental Health Intramural Research, NIH

Professor Thomas G. Schulze, MD studied medicine in Germany, the USA, and Catalonia. He trained as a psychiatrist and has held positions in Germany and the USA. Since 2014, he has held the position of Director of the Institute of Psychiatric Phenomics and Genomics at the Ludwig-Maximilans-University of Munich (IPPG). He currently serves as the President of the International Society of Psychiatric Genetics (ISPG).

Professor Francis J. McMahon, MD received his medical degree from Johns Hopkins in 1987, where he also completed a medical internship, a residency in adult psychiatry, and a post-doctoral fellowship in genetics. He is a Senior Investigator and Chief of the Human Genetics Branch in the National Institute of Mental Health Intramural Research Program at the US National Institutes of Health. He is also a visiting Professor of Psychiatry at the Johns Hopkins University School of Medicine and past president of the ISPG.

Contributors:

Schahram Akbarian, MD, PhD
Friedman Brain Institute
Departments of Psychiatry and Neuroscience
Mount Sinai School of Medicine
New York, NY

Nirmala Akula, PhD
Human Genetics Branch
National Institute of Mental Health Intramural Research Program
National Institutes of Health
Bethesda, MD

Laura Almasy, PhD
Department of Genetics
Perelman School of Medicine
University of Pennsylvania
Department of Biomedical and Health Informatics
Children's Hospital of Philadelphia
Philadelphia, PA

John Blangero, PhD
South Texas Diabetes and Obesity Institute
University of Texas Rio Grande Valley School of Medicine
Brownsville, TX

Sevilla D. Detera-Wadleigh, PhD
Human Genetics Branch
National Institute of Mental Health Intramural Research Program
National Institutes of Health
Bethesda, MD

Gokcen Eraslan, MSc
Institute of Computational Biology
Helmholtz Zentrum Munchen
Neuherberg, Germany

David C. Glahn, PhD
Department of Psychiatry
Yale University School of Medicine
New Haven, CT
Olin Neuropsychiatric Research Center
Institute of Living, Hartford Hospital
Hartford, CT

Tobias B. Halene, MD, PhD
Friedman Brain Institute
Departments of Psychiatry and Neuroscience
Mount Sinai School of Medicine
New York, NY
Mental Illness Research Education and Clinical Center (MIRECC)
James J. Peters VA Medical Center
Bronx, NY

Gregor Hasler, MD
Friedman Brain Institute
Departments of Psychiatry and Neuroscience
Mount Sinai School of Medicine
New York, NY
Division of Molecular Psychiatry
Translational Research Center
University Hospital of Psychiatry and Psychotherapy
University of Bern
Bern, Switzerland

Liping Hou, PhD
Human Genetics Branch
National Institute of Mental Health Intramural Research Program
National Institutes of Health
Bethesda, MD

Layla Kassem, PsyD, PhD
Malachite Institute for Behavioral Health, Corp
Washington, DC

Tadafumi Kato, MD, PhD
Laboratory for Molecular Dynamics of Mental Disorders
RIKEN Brain Science Institute
Wako, Japan

George Kirov, PhD
MRC Centre for Neuropsychiatric Genetics & Genomics
Institute of Psychological Medicine and Clinical Neurosciences
Cardiff University School of Medicine
Cardiff, Wales

Ivan Kondofersky, PhD
Institute of Computational Biology
Helmholtz Zentrum Munchen
Neuherberg, Germany
Department of Mathematics
Technische Universitat Munchen
Garching, Germany

Gonzalo Laje, MD
Director
Washington Behavioral Medicine Associates, LLC
Chevy Chase, MD

Jun Z. Li, PhD
Department of Human Genetics
University of Michigan
Ann Arbor, MI

Alison K. Merikangas, MPH, PhD
Postdoctoral Fellow
Neuropsychiatry Program
Department of Psychiatry
Perelman School of Medicine
University of Pennsylvania
Philadelphia, PA

Kathleen R. Merikangas, PhD
Senior Investigator and Chief
Genetic Epidemiology Research Branch
Intramural Research Program
National Institute of Mental Health
National Institutes of Health
Bethesda, MD

Amanda Mitchell, PhD
Friedman Brain Institute
Departments of Psychiatry and Neuroscience
Mount Sinai School of Medicine
New York, NY

Jennifer C. Moore, PhD
Department of Genetics
The Human Genetics Institute of New Jersey
RUCDR Infinite BiologicsRG
Rutgers, the State University of New Jersey
Piscataway, NJ

Nikola S. Mueller, PhD
Institute of Computational Biology
Helmholtz Zentrum Munchen
Neuherberg, Germany

James B. Potash, MD, MPH
University of Iowa Carver College of Medicine
Iowa City, IA

Shweta Ramdas, BSc
Program in Bioinformatics
University of Michigan
Ann Arbor, MI

Elliott Rees, PhD
MRC Centre for Neuropsychiatric Genetics & Genomics
Institute of Psychological Medicine and Clinical Neurosciences
Cardiff University School of Medicine
Cardiff, Wales

John P. Rice, PhD
Department of Psychiatry
Washington University
St. Louis, MO

Michael Sheldon, PhD
Department of Genetics
The Human Genetics Institute of New Jersey
RUCDR Infinite BiologicsRG
Rutgers, the State University of New Jersey
Piscataway, NJ

Julia C. Stingl, MD
Centre for Translational Medicine
University Bonn, Medical School Bonn
Federal Institute for Drugs and Medical Devices (BfArM)

Subha Subramanian, MD
University of Iowa Carver College of Medicine
Iowa City, IA

Fabian J. Theis, MSc, PhD
Institute of Computational Biology
Helmholtz Zentrum Munchen
Neuherberg, Germany
Department of Mathematics
Technische Universitat Munchen
Garching, Germany

Jay A. Tischfield, PhD
Department of Genetics
The Human Genetics Institute of New Jersey
RUCDR Infinite BiologicsRG
Rutgers, the State University of New Jersey
Piscataway, NJ

Karolina Worf, MS
Institute of Computational Biology
Helmholtz Zentrum Munchen
Neuherberg, Germany