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Published: 30 June 2019

562 Pages | 109 color & 2 B&W

7" x 10" inches

ISBN: 9781621822967

Bookseller Code (06)

Protein Homeostasis, Second Edition

Second Edition

Edited by Jeffery W. Kelly, Franz-Ulrich Hartl, and Richard Morimoto

A Cold Spring Harbor Laboratory Press Publication

Perspectives CSHL

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive update on how the proteostasis network functions in healthy cells and the diseases that result when protein quality control goes awry. The contributors examine the relevant biochemical attributes of proteins (e.g., solubility), the functions of normal protein aggregates (e.g., biofilm formation in bacteria), and the various heat shock proteins, chaperones, translocation machineries, proteasomes, signaling factors, and transcriptional programs involved in proteostasis. The roles of specific subcellular structures-the endoplasmic reticulum, mitochondria, ribosomes, lysosomes, and cytoplasm-in protein quality control are covered, as is the regulation of proteostasis at the organismal level (e.g., via neuronal activity).

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