Pharmacology in Anesthesia Practice

Edited by Anita Gupta and Nina Singh-Radcliff

Includes coverage of vitamins, herbal supplements, drugs of abuse, poisons, and new drugs on the horizon.
Highlights drug effects on pertinent body systems (e.g., cardiovascular effects, respiratory effects, neurological effects, etc.) as well as peri-operative risks and concerns.
Provides easy and rapid review of commonly used pharmacologic agents in anesthesia
Emphasizes clinical applications of the medications

Pharmacology in Anesthesia Practice

Edited by Anita Gupta and Nina Singh-Radcliff

Description

In anesthesia practice and treatment, pharmacology and therapeutics are intimately related, synergistic, and mutually reinforcing. Rapid advances in pharmacotherapy often offer myriad treatment options for clinicians to sort through when developing patient management strategies. In turn, the principles of clinical therapeutics are rooted in fundamental pharmacology. Clinicians must understand pharmacologic principles in order to formulate and implement therapeutic algorithms that maximize patient benefit. Pharmacology in Anesthesia Practice provides clinicians with a rapid and easy review of the most commonly utilized pharmacologic agents during perioperative care. Clinical application is emphasized throughout. It aims to offer clinicians point-of-care guidance from internationally recognized authors and centers of excellence.

Pharmacology in Anesthesia Practice

Edited by Anita Gupta and Nina Singh-Radcliff

Contributors
1 Inhalational Agents
1.1 Volatile Anesthetics
Philip Gallegos, MD, Nina Singh-Radcliff, MD
1.2 Nitrous Oxide
Philip Gallegos, MD and Nina Singh-Radcliff, MD
2 Induction Agents
2.1 Propofol
Ellen Wang, MD and Nina Singh-Radcliff, MD
2.2 Barbiturates
Katherine C. Normand, MD
3 Pain Medications
3.1 Opioids
Thomas H. Scott and Jane C. Ballantyne
3.2 Skeletal Muscle Relaxants
Chitra Ramasubbu, MD, Anita Gupta DO, PharmD
3.3 Non-Steroidal Anti-Inflammatory Drugs
Matthew Lesneski MD and Peter Yi MD
3.4 Acetaminophen
Chitra Ramasubbu, MD and Anita Gupta DO, PharmD
3.5 Benzodiazepines
Ellen Wang, MD
4 Muscle Relaxants
4.1 Nondepolarizing Neuromuscular Blockers
Jared Feinman, MD and Nina Singh-Radcliff, MD
4.2 Succinylcholine
Jared Feinman, MD and Nina Singh-Radcliff, MD
5 Anticholinergics and Anticholinesterases
5.1 Anticholinesterases
Devin Tang, MD and Anita Gupta, DO PharmD
5.2 Anticholinergics
Anita Gupta DO, PharmD, Amna Mehdi, BS
6 Vasopressors and Inotropes
Priscilla Nelson, MD, Jonas A. Nelson, MD, and Nina Singh-Radcliff, MD
7 Anti-Hypertensives
7.1 Beta Blockers
Anita Gupta DO, PharmD, and Amna Mehdi, BS
7.2 Antihypertensives
Onyi Onuoha, MD and Nina Singh-Radcliff, MD
8 Local Anesthetics
Nina Singh-Radcliff, MD
9 Antiemetics
Alissa Wilmot, MD and Sander Schlichter, MD
10 Gastric Medications
Shanique Brown, MD, and Nina Singh-Radcliff, MD
11 Anti-Inflammatory
11.1 Steroids
Lisa Witkin, MD, Anita Gupta, DO, PharmD
11.2 Antihistamines
Mona Patel, MD, and Anita Gupta, DO, PharmD
12 Narcotic and Benzodiazepine Reversal Agents
Gaurav Bhatia, MD, and Anita Gupta, DO, PharmD
13 Hematologic Agents
13.1 Dipyridamole
Elizabeth Duggan, MD
13.2 Adenosine Diphosphate Inhibitors
Michael J. Duggan, MD, Elizabeth W. Duggan, and Jiri Horak, MD
13.3 Low Molecular Weight Heparin (LMWH)
Elizabeth W. Duggan, MD, Michael J. Duggan, MD, and Maurizio Cereda, MD
13.4 Miscellaneous Anticoagulants
Michael J. Duggan, MD, Elizabeth W. Duggan, and Jiri Horak, MD
13.5 Streptokinase and Tissue Plasminogen Activator (tPA)
Elizabeth Duggan, MD and Michael Duggan, MD
13.6 Heparin and Argatroban
Crystal C. Wright, MD
13.7 Procoagulants
Peter Killoran, MD, and Katherine Normand, MD
14 Obstetrics
14.1 Prostaglandins (carboprost, misoprostol, alprostadil)
Cristianna Vallera, MD
14.2 Ergots (Methylergonovine Maleate)
Emily Baird, MD
14.3 Oxytocin (Pitocin)
Emily Baird, MD
14.4 Magnesium
Robert Gaiser, MD
14.5 Beta 2 Adrenergic Agonist (Terbutaline)
Robert Gaiser, MD
15 Antiepileptic Drugs
Emily E. Peoples, M.D.
16 Bronchodilators
Anita Gupta DO, PharmD, and Amna Mehdi, BS
17 IV Fluids
17.1 Crystalloids
Katherine Chuy, MD, and Nina Singh-Radcliff, MD
17.2 Colloids
Katherine Chuy, MD, and Nina Singh-Radcliff, MD
17.3 Transfusion Products
Nina Singh Radcliff, MD
18 Electrolytes
18.1 Sodium/Potassium/Calcium/Phosphate
Yianni Augoustides and Tygh Wyckoff
18.2 Sodium bicarbonate
Nina Singh-Radcliff, MD
19 Diuretics
20 Antiarrhythmics
20.1 Antiarrhythmics
Gaurav Malhotra, MD
21 Antihyperglycemic Agents
21.1 Insulin
Elizabeth Valentine, MD and Nina Singh-Radcliff, MD
22 Mood Stabilizers and Antidepressants
22.1 Monoamine Oxidase Inhibitors (MAOIs)
Gregory Moy, MD and Nabil Elkassabany, MD
22.2 Selective Serotonin Reuptake Inhibitors (SSRIs)
Gregory Moy, MD and Nabil Elkassabany, MD
22.3 Tricyclic Antidepressants (TCAs)
Gregory Moy, MD, and Nabil Elkassabany, MD
22.4 Antipsychotics
Gregory Moy, MD, and Nabil Elkassabany, MD
22.5 Lithium
Gregory Moy, MD and Nabil Elkassabany, MD
23 Antibiotics
23.1 Antibiotics
Nina Singh-Radcliff MD and Kris E. Radcliff, MD
23.2 Antivirals
Meghan Lane-Fall, MD and Todd Miano, PharmD, BCPS
24 Statins: HMG-CoA Reductase Inhibitors
Jason Choi, MD, and John G. Augoustides, MD
25 Vitamins/Herbals
Ellen Wang, MD
26 Illicit Substances
26.1 Cocaine
Nabil Elkassabany, MD
26.2 Drugs of Abuse
William Gao and Nabil Elkassabany
27 Other Key Drugs
27.1 1-deamino-8-D-arginine vasopressin (DDAVP)
Jesse Raiten, MD
27.2 Carbidopa
Shannon Bianchi, MD and Nina Singh-Radcliff, MD
27.3 Doxapram
Shannon Bianchi, MD
27.4 Caffeine
Shannon Bianchi, MD
27.5 Nitric oxide
Jesse Raiten, MD
27.6 Dexmedetomidine
Shannon Bianchi, MD
27.7 Acetylcysteine
Shannon Bianchi, MD
27.8 Adriamycin (Doxorubicin)
Matt N. Decker and Nina Singh-Radcliff, MD
27.9 Sugammedex
Mark Decker, MD, and Nina Singh-Radcliff, MD
27.10 Thyroid Medications
Mona Patel, MD, Anita Gupta, DO, PharmD

Pharmacology in Anesthesia Practice

Edited by Anita Gupta and Nina Singh-Radcliff

Author Information

Edited by Anita Gupta, Director of Pain Medicine, Drexel University College of Medicine, USA, and Nina Singh-Radcliff, Assistant Professor, Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, USA

Anita Gupta, DO, PharmD, is Chief of the Division of Pain Medicine and Regional Anesthesiology at Hahnemann University Hospital and Drexel College of Medicine. Nina Singh-Radcliff, MD, is Assistant Professor, Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine.

Contributors:

John G. Augoustides, MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Emily Baird, MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Jane C. Ballantyne. MD
Professor
Division of Pain Medicine
University of Washington
Seattle, Washington

Gaurav Bhatia, M.D.
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Shannon Bianchi, MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Shanique Brown, MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Maurizio Cereda, MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Jason Choi MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Katherine Chuy, MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Matt N. Decker, BS
Department of Anesthesiology and Critical Care
Hospital of the University of Pennslyvania
Philadelphia, PA

Elizabeth W. Duggan, MD
Department of Anesthesiology and Critical Care
Jefferson Health System
Philadelphia, PA

Michael J. Duggan, MD
Department of Anesthesiology and Critical Care
Jefferson Health System
Philadelphia, PA

Nabil Elkassabany, MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Jared Feinman, MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Robert Gaiser, MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Philip Gallegos, MD
Attending Anesthesiologist,
Contributor

William Gao
Attending Anesthesiologist,
Contributor

Anita Gupta DO, PharmD
Medical Director
University Pain Institute
Division of Pain Medicine & Regional Anesthesiology
Department of Anesthesiology and Perioperative MEdicine
Drexel University College of Medicine
Philadelphia, PA

Jiri Horak, MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Peter Killoran, MD
Attending Anesthesiologist,
Contributor

Meghan Lane-Fall, MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Matthew Lesneski, MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Gaurav Malhotra, MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Amna Mehdi, BS
Department of Public Health
Rutgers University
New Brunswick, NJ

Todd Miano, PharmD, BCPS
Contributor

Gregory Moy, MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Jonas A. Nelson, MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Priscilla Nelson, MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Katherine C. Normand, MD
Attending Anesthesiologist,
Contributor

Onyi Onuoha, MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Mona Patel, MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Emily E. Peoples, M.D.
Department of Anesthesiology and Critical Care
University of Michigan
Ann Arbor, MI

Jesse Raiten, MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Chitra Ramasubbu, MD
Department of Anesthesiology and Critical Care Medicine
Division of Pain Medicine
Johns Hopkins University
Baltimore, MD

Kris E. Radcliff, MD
Attending Physician, Contributor

Sander Schlichter, MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Thomas H. Scott. MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Nina Singh-Radcliff, MD
Contributor and Co-Editor

Devin Tang, MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Elizabeth Valentine, MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Cristianna Vallera, MD
Attending Anesthesiologist,
Contributor

Ellen Wang, MD
Attending Anesthesiologist,
Contributor

Alissa Wilmot, MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Lisa Witkin, MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadephia, PA

Crystal C. Wright, MD
Attending Anesthesiologist,
Contributor

Tygh Wycoff, MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Peter Yi, MD
Department of Anesthesiology and Critical Care
Hospital of the University of Pennsylvania
Philadelphia, PA

Pharmacology in Anesthesia Practice

Edited by Anita Gupta and Nina Singh-Radcliff

Reviews and Awards

"The purpose is to provide a quick and authoritative review of the pharmacology of medications routinely used in anesthesia practice. With an ever-increasing list of drugs, this book serves a very important purpose... Practicing anesthesiologists are the primary audience, but students and residents will find the book helpful as well. The book is written and edited by experienced clinicians who do the subject justice... The best part of the book is its brevity and clinical relevance. No words are wasted." - Tariq M. Malik, for Doody's, July 2013

Pharmacology in Anesthesia Practice

Edited by Anita Gupta and Nina Singh-Radcliff

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