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Pain in Women

Edited by May L. Chin, Roger B. Fillingim, and Timothy J. Ness

Evidence-based
Reviews underlying mechanisms and clinical management
Addresses both types of pain specific to women plus pain conditions with greater prevelence in women
The most up-to-date and evidence-based clinically relevant information regarding pain in women.

Pain in Women

Edited by May L. Chin, Roger B. Fillingim, and Timothy J. Ness

Description

As recently detailed in an Institute of Medicine Report, pain represents one of the most costly and prevalent public health conditions in the United States, and the burden of pain is substantially greater for women than men. Women make up half of the world's population. Yet, the overall treatment of pain in women remains challenging to this day. The differences between men and women are anatomical, physiological and psychosocial in nature. Consequently, several unique features come to mind when discussing pain as experienced by women, such as pain related to pregnancy, pain related specifically to female organs, and chronic painful conditions which have a higher prevalence in the female population.

The purpose of this book is to address the current understanding of mechanisms related to sex differences, and the clinical management of common acute and chronic painful conditions in women, using up-to-date evidence-based information. The painful conditions discussed include those that are specific to female anatomy and physiology and conditions that have a higher female prevalence.

The book is divided into three sections. The first section covers basic science topics related to sex differences in pain. The epidemiology of painful conditions with female prevalence; sex differences in response to pain, and to analgesics; the role of sex hormones and genotype in pain perception and analgesia; sex differences in cerebral responses to pain revealed by brain imaging ; and the role of psychosocial factors, including psychological interventions will be discussed in this section.

The second and third sections are clinically directed. The second section focuses on pain specific to female patients. Topics include the management of labor pain; the management of painful conditions during pregnancy; and the management of pain in the opioid tolerant pregnant patient. The latter includes discussion on the impact of pain management on the fetus in utero, and on the newborn who is breastfed. Chronic pain specific to females, including dysmenorrhea, chronic pelvic pain and vulvodynia will be discussed in this section. Cancer-related pain issues in women will be addressed in the chapter on persistent pain after breast cancer treatment and the chapter on interventional management of pelvic cancer pain.

The third section covers painful conditions with high female prevalence. These include fibromyalgia, chronic fatigue syndrome and neuropathic pain in complex regional pain syndrome. Visceral pain with female prevalence such as irritable bowel syndrome, chronic pelvic pain of undetermined etiology will also be addressed in this section. This section also includes chapters on the presentation of cardiac pain in women; headaches including migraine; and temporomandibular joint disorders and orofacial pain.

The book is intended for a wide readership, including physicians and allied healthcare professionals who encounter female patients with acute or chronic painful conditions. In addition, residents and medical students in training as well as graduate students in health sciences will benefit greatly from this book as they continue to learn about and manage difficult and complex issues related to pain in female patients.

Pain in Women

Edited by May L. Chin, Roger B. Fillingim, and Timothy J. Ness

Section I: SEX DIFFERENCES IN PAIN: EPIDEMIOLOGY, PAIN PERCEPTION, AND ANALGESIC RESPONSES

Chapter 1: Epidemiology of Pain Conditions with Higher Prevalence in Women
Linda LeResche
Chapter 2: Sex Differences in Experimental Pain Responses
Christopher D. King, Margarete Ribeiro-Dasilva and Roger B. Fillingim
Chapter 3: Brain Imaging: Sex Differences in Cerebral Response s to Pain
Katy Vincent and Irene Tracey
Chapter 4: Sex Differences in Analgesic Responses: Clinical and Experimental Studies
Marieke Niesters, Albert Dahan, Leon Aarts, and Elise Sarton

Section II: BIOPSYCHOSOCIAL FACTORS CONTRIBUTING TO SEX DIFFERENCES

Chapter 5: Sex-Dependent Genetic Contributions to Pain and Analgesia
Jeffrey S. Mogil
Chapter 6: Role of Sex Hormones in Pain and Analgesia
Rebecca Craft
Chapter 7: Role Psychosocial Factors and Psychological Interventions
Edmund Keough

Section III: FEMALE SPECIFIC PAIN

Chapter 8: Current Management of Labor Pain
Cynthia A. Wong
Chapter 9: Pain in Pregnancy
Maryam Jowza, Geeta Nagpal, and James P. Rathmell
Chapter 10: The Opioid Tolerant Pregnant Patient
Nilda E. Salaman and May L. Chin
Chapter 11: Chronic Pelvic Pain: Dysmenorrhea and Endometriosis
Amy Stenson and Andrea J. Rapkin
Chapter 12: Vulvodynia
Ursula Wesselmann and Peter Czakanski
Chapter 13: Persistent Pain After Breast Cancer Treatment
Kenneth Geving Andersen and Henrik Kehlet
Chapter 14: Interventional Techniques for Pelvic Cancer Pain
Kari Kopko Bancroft and Oscar A. de Leon-Casasola

Section IV: PAINFUL CONDITIONS WITH FEMALE PREVALENCE

Chapter 15: Fibromyalgia and Chronic Fatigue Syndrome
Alethia Baldwin Sellers and Daniel Clauw
Chapter 16: Complex Regional Pain Syndrome
Marissa de Mos and Frank J. P. M. Huygen
Chapter 17: Irritable Bowel Syndrome
Margaret D. Eugenio, Monica E. Jarrett, and Margaret M. Heitkemper
Chapter 18: Interstitial Cystitis/Bladder Pain Syndrome
Meredith T. Robbins and Timothy J. Ness
Chapter 19: Chronic Pelvic Pain of Uncertain Origin
Andrew Baranowski
Chapter 20: Cardiac Pain in Women
Eileen Handberg and Marian Limacher
Chapter 21: Migraine in Women
Satnam S. Nijjar, Jason Rosenberg, and B. Lee Peterlin
Chapter 22: Temporomandibular Joint Disorders and Orofacial Pain
Asma A. Khan, William Maixner, and Pei Feng Lim

Pain in Women

Edited by May L. Chin, Roger B. Fillingim, and Timothy J. Ness

Author Information

MLC: Professor of Anesthesiology and Critical Care Medicine, George Washington University, Washington, DC. RBF: Professor, University of Florida College of Dentistry; Staff Psychologist, Gainesville VA Medical Center, Gainesville, Florida. TN: Professor of Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama

Contributors:

Leon Aarts MD PhD
Department of Anesthesiology
Leiden University Medical Center
Leiden, The Netherlands

Kenneth Geving Andersen
Section for Surgical Pathophysiology
Department of Breast Surgery
Rigshospitalet
Copenhagen Universit
Copenhagen, Denmark

Kari Kopko Bancroft, MD
Resident in Anesthesiology
University at Buffalo, School of Medicine
Buffalo, NY

Andrew Baranowski, BSc Hons, MBBS, FRCA, MD, FFPMRCA
University College
London Hospitals
London, United Kingdom

May L. Chin
Professor of Anesthesiology and Critical Care Medicine
George Washington University
Washington, DC

Daniel Clauw, MD
University of Michigan
Ann Arbor, Michigan

Rebecca Craft
Washington State University
Pullman, WA

Peter Czakanski MD PhD
Departments of Anesthesiology/Division of Pain Management and Obstetrics & Gynecology
University of Alabama at Birmingham School of Medicine
Birmingham, AL

Albert Dahan MD PhD
Department of Anesthesiology
Leiden University Medical Center
Leiden, The Netherlands

Margaret D. Eugenio, MD
Fellow, Department of Internal Medicine
Division of Gastroenterology
School of Medicine
University of Washington
Seattle, WA

Roger B. Fillingim
Professor, College of Dentistry and Staff Psychologist
University of Florida
Gainesvile VA Medical Center
Gainesville, FL

Eileen Handberg, PhD, ARNP
Research Associate Professor of Medicine
Division of Cardiovascular Medicine
University of Florida College of Medicine
Gainesville, FL

Margaret M. Heitkemper, PhD
Professor , Department of Biobehavioral
Nursing and Health Systems
University of Washington
Seattle, WA

Frank J. P. M. Huygen, MD, PhD
Department of Anesthesiology
Erasmus MC
Rotterdam, The Netherlands

Monica E. Jarrett, PhD
Professor, Department of Internal Medicine
Division of Gastroenterology
School of Medicine
University of Washington
Seattle, WA

Maryam Jowza, M.D
Fellow in Pain Medicine
Department of Anesthesia, Critical Care and Pain Medicine
Massachusetts General Hospital
Boston, MA

Henrik Kehlet
Section for Surgical Pathophysiology
Rigshospitalet
Copenhagen Universit
Copenhagen, Denmark

Edmund Keogh, BSc, MSc, PhD
Centre for Pain Research & Department of Psychology
University of Bath,
Bath, United Kingdom

Asma A. Khan, BDS, PhD
Center for Neurosensory Disorders
University of North Carolina
Chapel Hill, NC

Christopher D. King
University of Florida, College of Dentistry
Gainesville, FL

Oscar A. de Leon-Casasola, MD
Professor of Anesthesiology and Medicine
Vice-Chair for Clinical Affairs
Dept. of Anesthesiology, University at Buffalo, School of Medicine
Chief, Pain Medicine and Professor of Oncology
Roswell Park Cancer Institute
Buffalo, NY

Linda LeResche, Sc.D.
Department of Oral Medicine
University of Washington
Seattle, WA

Pei Feng Lim, BDS, MS
Center for Neurosensory Disorders
University of North Carolina
Chapel Hill, NC

Marian Limacher, MD
Senior Associate Dean for Faculty Affairs and Professional Development
AHA Endowed Professor of Cardiovascular Research
University of Florida College of Medicine
Gainesville, FL

William Maixner DDS, PhD
Center for Neurosensory Disorders
University of North Carolina
Chapel Hill, NC

Marissa de Mos, MD, PhD
Department of Anesthesiology
Erasmus MC
Rotterdam, The Netherlands

Jeffrey S. Mogil
Dept. of Psychology and Centre for Research on Pain
McGill University
Montreal, Canada

Geeta Nagpal, M.D
Fellow in Pain Medicine
Department of Anesthesia, Critical Care and Pain Medicine
Massachusetts General Hospital
Boston, MA

Timothy J. Ness MD PhD
Department of Anesthesiology
University of Alabama at Birmingham
Birmingham, AL

Satnam S. Nijjar, MD
Department of Neurology
Johns Hopkins University School of Medicine
Baltimore, MD

Marieke Niesters MD MS
Department of Anesthesiology
Leiden University Medical Center
Leiden, The Netherlands

B. Lee Peterlin, DO
Department of Neurology
Johns Hopkins University School of Medicine
Baltimore, MD

Andrea J. Rapkin, MD
Professor, Department of Obstetrics and Gynecology
David Geffen School of Medicine at the University of California, Los Angeles
Los Angeles, CA

James P. Rathmell, M.D.
Chief, Division of Pain Medicine
Department of Anesthesia, Critical Care and Pain Medicine
Massachusetts General Hospital
Boston, MA

Margarete Ribeiro-Dasilva
University of Florida, College of Dentistry
Gainesville, FL, USA

Meredith T. Robbins PhD
Department of Anesthesiology
University of Alabama at Birmingham
Birmingham, AL

Jason Rosenberg, MD
Department of Neurology
Johns Hopkins University School of Medicine
Baltimore, MD

Nilda E. Salaman, M.D.
George Washington University
Washington, DC

Elise Sarton, MD, PhD
Department of Anesthesiology
Leiden University Medical Center
Leiden, The Netherlands

Alethia Baldwin Sellers, MD
University of Alabama at Birmingham
Birmingham, AL

Amy Stenson MD, MPH
Assistant Professor, Department of Obstetrics and Gynecology
David Geffen School of Medicine at the University of California, Los Angeles
Los Angeles, CA

Irene Tracey PhD
Centre for Functional Magnetic Resonance Imaging of the Brain
Nuffield Department Clinical Neurosciences
Nuffield Division Anaesthetics
University of Oxford
Oxford, United Kingdom

Katy Vincent MBBS, PhD
Centre for Functional Magnetic Resonance Imaging of the Brain
Nuffield Department Clinical Neurosciences
Nuffield Division Anaesthetics
Nuffield Department of Obstetrics and Gynaecology
University of Oxford
Oxford, United Kingdom

Ursula Wesselmann MD PhD
Departments of Anesthesiology/Division of Pain Management and Neurology
University of Alabama at Birmingham School of Medicine
Birmingham, AL

Cynthia A. Wong, MD
Northwestern University Feinberg School of Medicine
Chicago, IL