Oxford Textbook of Headache Syndromes

Michel Ferrari,Andrew Charles,David Dodick,Fumihiko Sakai,Joost Haan

Michel D. Ferrari, MD, PhD, FANA, FRCP is Professor of Neurology, Chair of the Leiden Centre for Translational Neuroscience, and a member of the Permanent Science Committee at Leiden University Medical Centre (LUMC). He is the former President of the International Headache Society (IHS) and is currently President of the Dutch Headache Society.

Professor Ferrari was awarded the quinquennial Winkler Medallion for Excellence in Research from the Dutch Neurological Association in 2005, the Vici Innovational Research Personal Incentive Schema Award from the Netherlands Organisation for Scientific Research in 2004, and the Spinoza Life Time Achievement Premium in 2009. In 2017 he received the 10-year Gravity Award for his work for the Netherlands Organ-on-Chip Initiative. He is an Elected Fellow of the Royal College of Physicians (FRCP) and the American Neurological Association (FANA), and an Honorary Member of the Colombian Neurology Society and the International Headache Society.

Joost Han, MD, PhD, BA, is an Associate Professor of Neurology at Leiden University Medical Centre. He received his medical degree in 1982, his specialty certificate in Neurology in 1988, and his doctorate in clinical Neurophysiology in 1990. Between 2001 and 2007, Dr Haan was a member of the Council of Dutch Neurologists. Having co-authored over 150 peer-reviewed publications and several books on clinical genetics, Dr Haan serves on the scientific board of several Dutch scientific organisations and the editorial board of a number of journals. The main topics of his research are the genetics of headache (migraine, cluster headache), haemorrhagic stroke (cerebral amyloid angiopathy), and ischaemic stroke (CADASIL).


Andrew Charles, MD, is Professor and Director of the Headache Research and Treatment Program in the Department of Neurology at the David Geffen School of Medicine at University of California, Los Angeles (UCLA). In 2013 he was named the Meyer and Renee Luskin Chair in Migraine and Headache Studies at UCLA. As Director of the Headache Research and Treatment Program, Dr. Charles seeks to advance headache medicine through education, clinical research, and patient care. From 2011-2013 he was Co-Chair of the NINDS Common Data Elements Project Group for Headaches. He is an associate editor of the journal Cephalalgia, and serves on the board of directors of the American Headache Society and the board of trustees of the International Headache Society (IHS).


David W. Dodick, MD, FRCO (C), FACP, is Professor of Neurology at the Mayo Clinic College of Medicine and Consultant in Neurology at Mayo Clinic in Scottsdale, Arizona. Formerly President of the American Headache Society, President of the American Migraine Foundation, and President-elect of the International Headache Society (IHS), he is Program Director of the Mayo Clinic Neurology Residency Program and Medical Director of the Headache and Sport Neurology and Concussions programs. Mr. Dodick is Chairman and member of the Medical Advisory Board of eNeura Inc., a member of the Advisory Board at Alder Pharmaceuticals Inc., and co-director of the annual meeting of the American Headache Society. He is board certified by the Royal College of Physicians and Surgeons of Canada and the American Board of Psychiatry and Neurology.

Mr. Dodick has authored more than 300 peer-reviewed publications and co-authored 8 books. He is Editor in Chief of Cephalalgia.

Fumihiko Sakai, MD, is Professor at Saitama Medical University. Professor Sakai obtained his medical degree from Keio University and served as a research fellow with the Department of Neurology at Baylor College of Medicine and a clinical fellow at Keio University Hospital. In 1978 and 1979, he received the 13th and 14th Harold G. Wolff awards from the American Headache Society. He has served as a board member and honorary member of the Societas Neurologica Japonica and as President and Honorary Life Member of the International Headache Society (IHS).

Professor Sakai is currently a member of the board of the Japanese Headache Society, Director of Saitama International Headache Center, and a member of the Scientific Advisory Board at Trigemima.

Jes Olesen, Department of Neurology, Glostrup Hospital, Glostrup, Denmark

A. MaassenVanDenBrink, Department of Internal Medicine, Division of Pharmacology, Erasmus Medical Center, Rotterdam, The Netherlands

A. Scher, Department of Preventive Medicine and Biometrics, Uniformed Services University, Bethesda, USA


Agnes van Sonderen, Department of Neurology, Leyenburg Hospital,The Hague, The Netherlands

Alan C. Newman, Cedars-Sinai Pain Center; Program for Headache, Orofacial Pain and Sleep Apnea, lecturer, department of oral medicine and orofacial pain, UCLA School of Dentistry, Los Angeles, USA

Alan M. Rapoport, Clinical Professor of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, California, USA

Amaal Starling, Department of Neurology, Mayo Clinic Hospital, Phoenix, USA

Ana Marissa Lagman-Bartolome, Clinical Associate, Centre for Headache, Division of Neurology, Women's College Hospital, University of Toronto, Toronto, Canada

Andreas Straube, Department of Neurology, University of Munich, Munich, Germany

Andrew Charles, Professor of Neurology, Director, UCLA Goldberg Migraine Program
Meyer and Renee Luskin Chair in Migraine and Headache Studies
David Geffen School of Medicine at UCLA, USA

Andrew D. Hershey, Department of Pediatrics, Division of Neurology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, College of Medicine, Cincinnati, USA

Aneesh B. Singhal, Vice-Chair of Neurology, Department of Neurology, Stroke Service,
Massachusetts General Hospital, Boston, USA

Antonio Carolei, Institute of Neurology, Department of Applied Clinical Sciences and Biotechnology, University of L'Aquila, Italy

Arne May, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Aydin Gozalov, Danish Headache Center and Department of Neurology, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2600 Glostrup, Copenhagen, Denmark

Benedetti Bellini, Department of Pediatrics and Child and Adolescent Neuropsychiatry, Sapienza University di Roma, Rome, Italy

Brian M. Grosberg, Director, Hartford Healthcare Headache Center, Department of Neurology University of Connecticut School of Medicine, USA

C. Mark Sollars, Associate Editor, Projects Department, McMahon Publishing Group

Carrie E. Robertson, Department of Neurology, Mayo Clinic, Rochester, USA

Catherine Maurice, Neuro-Oncology fellow, University of Toronto, Princess Margaret Hospital, Pencer Brain Tumour Clinic, Canada

Christina Sun-Edelstein, Department of Clinical Neurosciences, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia

Dagny Holle, Department of Neurology, University hospital Essen, Essen, Germany

David P. Kernick, St Thomas Health Centre, Exeter, UK

David W. Dodick, Professor, Department of Neurology, Mayo Clinic, Scottsdale, Arizona, USA

Deborah I. Friedman, Departments of Neurology & Neurotherapeutics and Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

Delphine Magis, University Department of Neurology, CHR Citadelle, Belgium

Dorian A. Lamis

Dorothee Kasteleijn Nolst Trenité, Child Neurology, Pediatric Headache Centre, Sleep Disorders Centre, Chair of Pediatrics, NESMOS Dept., Faculty of Medicine & Psychology, Sapienza University, Rome, Italy


E.G.M. Couturier, Boerhaave Medisch Centrum, Amsterdam, The Netherlands

Elisabetta Cittadini, Functional Magnetic Resonance Imaging of the Brain Centre,
Pain Group, Oxford University, Oxford, UK

Elizabeth Leroux,Departement de Neurologie, Hopital Notre-Dame du CHUM, Montreal, Quebec, Canada

Esma Dilli, Clinical Assistant Professor of Neurology, University of British Columbia, Canada

Farnaz Amoozegar, Clinical Assistant Professor, Dept Clinical Neurosciences, Cumming School of Medicine, University of Calgary and Hotchkiss Brain Institute, Canada

Federico Mainardi, Headache Centres, Department of Neurology, SS Giovanni e Paolo Hospital, Venice, Italy

Frank Andrasik, Distinguished Professor and Chair, Department of Psychology, Psychology Building, University of Memphis, Memphis, USA

Fumihiko Sakai , Director, Professor, Saitama International Headache Centre
Saitama Neuropsychiatric Institute, Saitama, Japan

G. Bussone, Clinical Neuroscience Department, Neurological Institute IRCCS C.Besta, Milano, Italy

G. M. Terwindt, Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands

Gene Hunder, Emeritus Member, Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, USA

Germán Morís, Neuroscience Area, Service of Neurology, Asturias Central University Hospital, Oviedo, Spain

Gerrit L.J. Onderwater, Department of Neurology, Leiden University Medical Centre, the Netherlands

Giorgio Zanchin, Padua University, Padua, Italy

Gisela M. Terwindt, Department of Neurology, Leiden University Medical Centre, Leiden, the Netherlands

Guus G. Schoonman, Elisabeth-Tweesteden Hospital,Tilburg, the Netherlands

Henrik Winther Schytz

Hille Koppen, Department of Neurology, Leyenburg Hospital,The Hague, The Netherlands

Hine J.A. van Os, Leiden University Medical Center, Department of Neurology, Leiden, The Netherlands

Ilse F. de Coo, Department of Neurology Leiden University Medical Centre, Leiden, The Netherlands

James W. Lance, University of New South Wales, Sydney, New South Wales, Australia

Jan Hoffmann, Institute of Psychiatry, Psychology and Neuroscience, King's College London,
London, UK

Jerry W. Swanson, Department of Neurology, Mayo Clinic, Rochester, USA

Joanna M. Zakrzewska, Facial pain unit, Division of Diagnostic, Surgical and Medical Sciences, Eastman Dental Hospital, UCLH NHS Foundation Trust, London, UK

Johan Lim, Department of Neurology. Alrijne Hospital Leiderdorp. The Netherlands

Johannes A. Carpay, Department of Neurology, Tergooiziekenhuizen, Hilversum, the Netherlands

Jonathan H. Smith, Department of Neurology, Mayo Clinic, Rochester, USA

Jonathan P. Gladstone, Director, Gladstone Headache Clinic, Headache Specialist, The Hospital for Sick Children, Sunnybrook Health Sciences Centre, Toronto Rehabilitation Institute and Cleveland Clinic Canada, Toronto, Ontario, Canada

Joost Haan, Associate professor, Leiden University Medical Centre and Alrijne Hospital Leiderdorp, The Netherlands

Juan A. Pareja,Department of Neurology, University Hospital Fundación Alcorcón, Madrid, Spain

Julio Pascual, Neuroscience Area, Service of Neurology, Asturias Central University Hospital, Oviedo, Spain

K. Ibrahimi, Department of Internal Medicine, Division of Pharmacology, Erasmus Medical Center, Rotterdam, The Netherlands

Kathleen Digre, Department of Ophthalmology, John A Moran Eye Center, University of Utah Health Sciences Center, Salt Lake City, USA

Kuan-Po Peng, Department of Systems Neuroscience, University Clinic Hamburg Eppendorf (UKE) Hamburg, Germany; Brain Research Center, National Yang-Ming University, Taipei, Taiwan

Laura Papetti, Department of Pediatrics, Child Neurology Division, “Sapienza” University of Rome, Italy

Leopoldine A. Wilbrink, Department of Neurology Leiden University Medical Centre, Leiden, The Netherlands

M. A. Louter, Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands

M. J. Eadie, University of Queensland, Indooroopilly, Brisbane, Australia

Mamoru Shibata, Department of Neurology, School of Medicine, Keio University, Shinjuku-ku,
Tokyo, Japan

Maria Chiara Paolino, Child Neurology, Pediatric Headache Centre, Sleep Disorders Centre, Chair of Pediatrics, NESMOS Dept., Faculty of Medicine & Psychology, “Sapienza University”, Rome, Italy

María Luz Cuadrado, Headache Unit, Department of Neurology, San Carlos Clinical Hospital, Madrid, Spain

Marieke J.H. Wermer, Leiden University Medical Center, Department of Neurology, Leiden, The Netherlands

Marina de Tommaso, Neuroscience and Sensory System, Department Bari Aldo Moro University, Policlinico General Hospital, Neurological Building, Bari, Italy

Mark C. Kruit, Department of Radiology, Leiden University Medical Centre, RC Leiden, the Netherlands

Matthew S. Robbins, Matthew S. Robbins, Department of Neurology, Weill Cornell Medicine, New York, USA

Matthijs C. Brouwer, Academic Medical Center, Department of Neurology, Amsterdam, The Netherlands

Maurice Vincent, Medical Fellow - Neuroscience Research, Eli Lilly and Company, Indianapolis, USA

Maurizio Pompili, School of Health Sciences, Sapienza University of Rome, Department of Medical and Molecular Sciences, Rome, Italy

Messoud Ashina, Associate Professor, Department of Neurology, University of Copenhagen, Danish Headache Center, DHC Glostrup Hospital Nord, Glostrup, Denmark

Michel D. Ferrari, Department of Neurology, Leiden University Medical Centre, the Netherlands

Miguel JA Láinez, Servicio de Neurología. Hospital Clínico Universitario, Valencia, Spain

Nadine Pelzer, Department of Neurology, Leiden University Medical Centre, Leiden, the Netherlands

Nikolai Bogduk, Emeritus Professor of Pain Medicine, University of Newcastle, Newcastle, UK

Norihiro Suzuki, Department of Neurology, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan

Ore-ofe O. Adesina, Clinical Assistant Professor of Ophthalmology & Neurology, Ruiz Department of Ophthalmology and Visual Science, Houston, Texas, USA

P. J. Koehler, Department of Neurology, Atrium Medical Centre, The Netherlands

Paolo Martelletti, School of Health Sciences, Sapienza University of Rome, Department of Medical and Molecular Sciences, Rome, Italy

Pasquale Parisi, Child Neurology, Pediatric Headache Centre, Sleep Disorders Centre, Chair of Pediatrics, NESMOS Dept., Faculty of Medicine & Psychology, “Sapienza University”, Rome, Italy

Peter J. Goadsby, Headache Group, NIHR-Wellcome Trust Clinical Research Facility,
King's College London, London, UK

Peter van den Berg, Department of Neurology, Isala kliniek, Zwolle, The Netherlands

Randolph W. Evans, Clinical Professor of Neurology, Baylor College of Medicine, Houston,
Texas, USA

Rashmi B. Halker, Department of Neurology, Mayo Clinic Hospital, Phoenix, USA

Richard B. Lipton, Edwin S. Lowe Professor and Vice Chair of Neurology, Professor of Epidemiology and Population Health,Director, Montefiore Headache Center, Albert Einstein College of Medicine, Bronx, New York, USA

Richard Peatfield, Princess Margaret Migraine Clinic, Charing Cross Hospital, London UK

Rigmor Jensen, Danish Headache Centre, Copenhagen, Denmark

S. Labruijere, Department of Internal Medicine, Division of Pharmacology, Erasmus Medical Center, Rotterdam, The Netherlands

Sebastiaan F. T, M De Bruijn, Department of Neurology, Leyenburg Hospital,The Hague, The Netherlands

Shih-Pin Chen, Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan

Shuu-Jiun Wang, Brain Research Center and School of Medicine, National Yang-Ming University Neurological Institute, Taipei-Veterans General Hospital. Taipei, Taiwan

Simona Sacco, Institute of Neurology, Department of Applied Clinical Sciences and Biotechnology, University of L'Aquila; Italy

Stefan Evers, Department of Neurology, University of Münster, Germany

Stephen D. Silberstein, Professor of Neurology and Director, Jefferson Headache Center
Thomas Jefferson University, Philadelphia, USA

Steven B. Graff-Radford†, Director, The Program for Headache and Orofacial Pain, Cedars-Sinai Medical Center, Los Angeles, USA

Sudama Reddi

Sylvia Lucas, Clinical Professor of Neurology & Neurological Surgery Adjunct, Rehabilitation Medicine, Wadsworth Term Clinical Professor in Headache Research and Practice, University of Washington Medical Center, Harborview Medical Center, Seattle, Washington, USA

T. H. Dirkx

Tobias Freilinger, Department of Neurology, Passau Hospital, Passau, Germany

Vesselina Grozeva, Servicio de Neurología. Hospital Clínico Universitario, Valencia, Spain
Vincent T. Martin, University of Cincinnati, USA

Vincenzo Guidetti, Department of Pediatrics and Child and Adolescent Neuropsychiatry, Sapienza University di Roma, Rome, Italy

Vittorio Sciruicchio

Werner J. Becker, Professor Emeritus, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Canada

Yoon-Hee Cha, Associate Professor of Neurology, Laureate Institute for Brain Research, Tulsa, OK, USA

"This book is the quintessential reference text on headache medicine. As a neurology resident pursuing headache specialization, I anticipate consulting this book often. Although headache is a constantly evolving field, this multi-authored text is up to date and extremely comprehensive." -- E.M.G. DePoy, MD, Thomas Jefferson University, Doody's Review Service