Oxford Textbook of Cancer in Children

Andrea Biondi, Director of the Department and the School of Paediatrics, San Gerardo Hospital, and Professor of Paediatrics, Faculty of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy,Hubert N. Caron, Professor of Pediatric Oncology, Emma Children's Hospital AMC, University of Amsterdam, Amsterdam, The Netherlands,Tom Boterberg, Head of the Department of Radiation Oncology, Ghent University Hospital, and Associate Professor, Ghent University, Ghent, Belgium,François Doz, Professor of Paediatrics, School of Medicine, University Paris, Descartes, and Paediatric Oncologist and Deputy Director for clinical research and training, SIREDO Oncology Centre, Institut Curie, Paris, France

Andrea Biondi M.D., took the degree in Medicine in 1979 at the University of Milano, Italy and in 1982 and 1994 the Specialization in Pediatrics and Haematology respectively. In 1982-84 he was Research Associate in Pathology at the Dana Farber Cancer Institute-Harvard Medical School, Boston, USA. In 1986-1987 he was Research Associate in Medicine at the Ontario Cancer Institute, Toronto, Canada. Since November 2009, he has been the Director of the Department and the School of Paediatrics, University of Milano-Bicocca, San Gerardo Hospital, Monza (MI), Italy. He is head of the M.Tettamanti Research Centre and of S. Verri Cellular and Gene Therapy Laboratory, San Gerardo Hospital, Monza (MI), Italy. Since 2007 he has been Coordinator of the Ph.D. Program in Translational and Molecular Medicine at University of Milano-Bicocca, Milan, Italy. From 2004-08 he was President of SIOP Europe. His clinical and research interests relate to childhood leukaemia and to cell and gene therapy.

Tom Boterberg graduated as an MD in 1994 at Ghent University. After one year of residency in radiation oncology, he worked for 4 years at the Laboratory of Experimental Cancer Research on the biology of the invasive and metastatic behaviour of breast cancer cells. He obtained his PhD in 2000. Afterwards he continued his training in radiation oncology and in 2001 he obtained his Board Certificate in Radiation Oncology. Since 2001 he works as a staff member at the Department of Radiation Oncology at Ghent University Hospital. He is especially interested in paediatric radiotherapy. He is actively involved in the radiotherapy committees of SIOPEN (neuroblastoma) and EpSSG (rhabdomyosarcoma). He is board member of SIOPE and chairs the QUARTET project on quality assurance in paediatric radiotherapy. He is author or co-author of over 100 articles in peer-reviewed journals. His other interests are haematology, neuro-oncology, intra-operative brachytherapy and radioprotection.

Hubert Caron graduated in medicine in 1985 from the Medical School, University of Amsterdam, trained in paediatrics and in paediatric oncology in Emma Children's Hospital, AMC Amsterdam and was appointed professor in paediatric oncology in 2001. He received his PhD (cum laude) in 1995 on the subject "Chromosome 1P in Neuroblastoma: suppressors and prognosis". His main research interests are tumour biology, rational targeted drug design, early new drug trials, systematic reviews of effectiveness of interventions in paediatric oncology and late effects of treatment. Since 2014 he also holds a position as medical director at Roche, where he is responsible for the global clinical development of the oncology portfolio of Roche for children with cancer.

François Doz is professor of Paediatrics at the University Paris Descartes and paediatric oncologist at Institut Curie, Paris. He got his MD, paediatric specialty and master in pharmacology in Paris. He then spent two years as a research fellow in the Brain Tumour Research Center, University of California, San Francisco. His main research interests are Paediatric Neuro-oncology, Retinoblastoma, Early Drug Development and Ethics of Clinical Research. He is past- member (2011-2013, 2017) and past-chair (2014-2016) of the SIOP scientific committee, past-chair of the scientific committee of the SFCE (French paediatric cancer society) (2007-2011), member of the SIOPE Board, past- chair of the SIOP-Europe Brain Tumour Group (2006-2010) and of its Medulloblastoma/PNET working group (2013-2016), member of the clinical trial committee and of the executive committee of the ITCC consortium (Innovative Treatment for Children with Cancer) and current co-chair of the European Retinoblastoma Group.

Femke Aarsen, Pediatric Clinical Neuropsychologist, Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
Maurizio Aricò, Coordinator of Rare Pediatric Diseases Center, Meyer University Hospital, Florence, Italy
Adriana Balduzzi, Pediatric Clinic University of Milan Bicocca, MBBM Foundation, San Gerardo Hospital, Monza, Italy
Christophe Bergeron, Paediatric Oncologist, Institute of Hematology and Pediatric Oncology (IHOPE), Centre Léon Bérard, Lyon, France
Stefan Bielack, Medical Director, Department of Pediatric Oncology, Hematology and Immunology, Stuttgart Cancer Center, Stuttgart Hospital- Olgahospital, Stuttgart, Germany.
Andrea Biondi, Professor of Pediatrics, University of Milano-Bicocca, and Director, Department of Pediatrics, Fondazione MBBM /Hospital S.Gerardo, Monza, Italy
Gianni Bisogno, Department of Women's and Children's Health, University of Padua, Padua, Italy
Tom Boterberg, Associate Professor, Department of Radiation Oncology, Ghent University Hospital, Belgium
Eric Bouffet, Garron Family Chair in Childhood Cancer Research, Director, Paediatric Neuro-Oncology Program, and Professor of Paediatrics, Hospital for Sick Children, Toronto, Canada
Garrett Brodeur, Director of the Cancer Predisposition Program, Children's Hospital of Philadelphia, and Associate Director, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
Gabriele Calaminus, Department of Paediatric Hematology and Oncology, Bonn University Children's Hospital, Bonn, Germany
Hubert N. Caron, Professor of Paediatric Oncology, Emma Children's Hospital AMC, University of Amsterdam, Amsterdam, the Netherlands
Guillermo Chantada, Head of Precision Medicine, JP Garrahan Hospital, and Principal Researcher, CONICET, Buenos Aires, Argentina; Associated Member, Hospital Sant Joan de Deu, Barcelona, Spain
Cecile Faure Conter, Pediatric Oncologist, Institute of Pediatric Hematology and Oncology (IHOPe), Lyon, France
Finella Craig, Consultant in Paediatric Palliative Medicine, Great Ormond Street Hospital for Children, London, UK
Jean-Hugues Dalle, Head of HSCT Pediatric Unit, Hematology and Immunology Department, Robert-Debre Hospital, Assistance Publique, Hopitaux de Paris and University of Paris, Paris, France
Gianpietro Dotti, Professor, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, USA
François Doz, Professor of Pediatrics, School of Medicine, University Paris Descartes, and Paediatric Oncologist, SIREDO center, Institut Curie, Paris, France
Angelika Eggert, Director, Department of Paedriatrics, Division of Oncology and Hematology, Charité University Medical Center Berlin, Berlin, Germany
Andrea Ferrari, Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
Didier Frappaz, Institut d'Hématologie Oncologie Pédiatrique, Lyon, France
Stefania Galimberti, Professor of Medical Statistics, University of Milano-Bicocca, Milan, Italy
Maria Luisa Garrè, Department of Neuro-oncology, IRCCS Istituto Giannina Gaslini, Genova, Italy
Gemma Gatta, Evaluative Epidemiology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
Mark Gaze, Consultant Clinical Oncologist, University College London Hospitals and Great Ormond Street Hospital for Children, London, UK
Norbert Graf, Department of Pediatric Oncology and Hematology, Saarland University, Homburg, Germany
Martha Grootenhuis, Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
Rupert Handgretinger, Chair, Department of Hematology/Oncology, Children's University Hospital, University of Tuebingen, Tuebingen, Germany
Darren Hargrave, Haematology and Oncology Department, Great Ormond Street Hospital for Children, London, UK
Henrik Hasle, Professor of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
Riccardo Haupt, Epidemiology and Biostatistics Unit, DOPO Clinic, IRCCS Istituto Giannina Gaslini, Genova, Italy
Lee Helman, Attending Physician, Children's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, Los Angeles, USA
Koichi Hirabayashi, Lineberger Comprehensive Cancer Centre, University of North Carolina, Chapel Hill, USA
Lars Hjorth, Consultant Paediatric Oncology & Haematology, Department of Paediatrics, Skåne University Hospital, Clinical Sciences, Lund University, Sweden
Scott C. Howard, Professor and Associate Dean for Research in the College of Nursing, University of Tennessee College of Health Sciences, Memphis, USA
Thierry A.G.M. Huisman, Radiologist-in-Chief, Texas Children's Hospital, Houston, USA
Trijn Israëls, Paediatric Oncologist, Coordinator Clinical Research Sub-Saharan Africa, Outreach Programme, Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
Momcilo Jankovic, Pediatric Hemato-Oncologist, Pediatric Clinic University of Milano-Bicocca, Foundation MBBM, Monza, Italy
Lucy J. W. Jones, Medical Oncology Registrar, St James's University Hospital, Leeds, UK
David T. W. Jones, Pediatric Glioma Research Group, Hopp Children's Cancer Center Heidelberg (KiTZ), and German Cancer Research Center (DKFZ), Heidelberg, Germany
Gertjan J.L. Kaspers, Director Academy, Princess Máxima Center for Pediatric Oncology, Utrecht, and Professor of Pediatric Oncology, Amsterdam UMC/Vumc, Amsterdam, the Netherlands
Pamela Kearns, Professor of Clinical Paediatric Oncology, Institute of Cancer and Genomic Sciences, University of Birmingham, and Honorary Consultant, Birmingham Children's Hospital, Birmingham, UK
Michelle Koh, Paediatric Palliative Care Consultant, University Hospital Southampton NHS Foundation Trust, Southampton, UK
Leontien C. M. Kremer, Department of Paediatrcis, Amsterdam UMC, Amsterdam, the Netherlands
Leontien Kremer, Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
Judith Landman-Parker, Pediatric Hematology and Oncology Department, Armand Trousseau Hospital, Paris, France
Erik A.H. Loeffen, Pediatrician-in-training, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, The Netherlands
Mignon Loh, Professor of Clinical Pediatrics, Division of Hematology Oncology, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, USA
Giovanna Lucchini, BMT Department, Great Ormond Street Hospital for Children, London, UK
Maura Massimino, Pediatric Unit Director, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
Kieran McHugh, Consultant Paediatric Radiologist, Great Ormond Street Hospital for Children, London, UK
Hans Merks, Pediatric Oncologist, Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
Gisela Michel, Department of Health Sciences and Health Policy, University of Lucerne, Lucerne, Switzerland
Véronique Minard-Colin, Department of Paediatrics, Institut Gustave Roussy, Paris, France
Elizabeth Molyneux, Honarary Professor of Paediatrics and Child Health, University of Malawi College of Medicine, Malawi, and Strategic Advisor for East and West Africa, Royal College of Paediatrics and Child Health, London, UK
Françoise Montravers, Head of the Nuclear Medicine Department, Assistance Publique Hôpitaux de Paris, Paris, France
Lucas Moreno, Clinical Director, Paediatric Oncology & Haematology, Hospital Universitari Vall d'Hebron, Barcelona, Spain
James C. Nicholson, Division of Paediatric Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
Charlotte M. Niemeyer, Professor, Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany
Kristian W. Pajtler, Department of Pediatric Neurooncology, Cancer Research Center (DKFZ), Heidelberg, Germany
Catherine Patte, Department of Paediatrics, Institut Gustave Roussy, Paris, France
Michael Paulussen, Medical Director, Datteln Children's Hospital, Datteln, and Chair of Pediatrics, Witten/Herdecke University, Witten, Germany
Giorgio Perilongo, Department of Women's and Children's Health, University of Padua, Padua, Italy
Stefan M. Pfister, Head of the Department of Pediatric Neurooncology, Cancer Research Center (DKFZ), Heidelberg, Germany
Bob S. Phillips, Centre for Reviews and Dissemination, University of York, York, UK, and Leeds Children's Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK
Rob Pieters, Pediatric Oncologist, Board of Directors, and Chief Medical Officer, Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
Vijay Ramaswamy, Assistant Professor, Division of Haematology and Oncology, Hospital for Sick Children, Toronto, Canada
Dirk Reinhardt, Director, Pediatrics III and Department of Pediatric Oncology, Hematology, Pneumology, Stem Cell Therapy, Cardiology and Rheumatology, University Hospital Essen, Essen, Germany
Carlos Rodríguez-Galindo, Executive Vice-President, Chair of the Department of Global Paediatric Medicine, and Director of St. Jude Global, St. Jude Children's Research Hospital, Memphis, USA
Emmanouil Saloustros, Department of Oncology, University Hospital of Larissa, Larissa, Greece
Barbara Savoldo, Lineberger Comprehensive Cancer Centre, University of North Carolina, Chapel Hill, USA
Denis Schewe, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany
Gudrun Schleiermacher, Pediatric Oncologist, Institut Curie, Paris, France
Martin Schrappe, Chair of Pediatrics, Christian-Albrechts University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany
Rod Skinner, Department of Paediatric and Adolescent Haematology and Oncology, and Children's BMT Unit, Great North Children's Hospital, Newcastle upon Tyne, Newcastle, UK
Dan Stark, Associate Professor of Cancer Medicine and Honorary Consultant in Medical Oncology, Leeds Institute for Medical Research and Leeds Teaching Hospitals NHS Trust, Leeds, UK
Charles Stiller, Lead on Childhood Cancer, National Cancer Registration and Analysis Service, Public Health England, UK
Dominik Sturm, Physician Scientist, Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany
Maria Grazia Valsecchi, Professor of Medical Statistics, University of Milano-Bicocca, Milan, Italy
Marianne van de Wetering, Pediatric Oncologist, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Esther van den Bergh, Clinical Psychologist, Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
Cor van den Bos, Pediatric Oncologist, Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
Dannis van Vuurden, Paediatric Neuro-Oncologist, VU University Medical Center, Amsterdam, the Netherlands
Gareth J. Veal, Professor of Cancer Pharmacology, Newcastle University, Newcastle, UK
David A. Walker, Professor of Paediatric Oncology, Children's Brain Tumour Research Centre, University of Nottingham, Nottingham, UK
Sheila Weitzman, Pediatric Oncologist, The Hospital for Sick Children, Toronto, Canada
Shaarna Whitton, Children's Brain Tumour Research Centre, University of Nottingham, Nottingham, UK
Joanne Wolfe, Director, Pediatric Palliative Care, Boston Children's Hospital, and Division Chief, Pediatric Palliative Care Service, Department of Psychosocial Oncology and Palliative Care, Dana-Farber, Cancer Institute, Boston, USA
Michel Zerah, Head of the Department of Pediatric Neurosurgery, Hopital des Enfants Malades, Paris, France
Jozsef Zsiros, Pediatric Oncologist, Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands
Michel Zwaan, Princess Máxima Center for Pediatric Oncology, Utrecht, and Erasmus MC, Rotterdam, the Netherlands

"This seventh edition has been thoroughly revised and updated, including brand new chapters on cancer immunotherapy in children, and cancer in adolescents and young adults, plus expanded treatment of tumours of the brain and central nervous system. The book primarily provides clear and up-to-date clinical guidance for use in treatment settings whilst offering a useful background to the biology of individual tumour types and the history of the development of specific treatments." -- Anticancer Research