Ovarian Cancer Immunotherapy

Edited by Samir A. Farghaly

Provides overview of basic sciences, and clinical and therapeutic aspects of immunotherapy for ovarian cancer
Chapters are written by a team of expert contributors from renowned medical institutions around the world
Ideal resource for clinicians and medical students caring for patients with ovarian cancer

Ovarian Cancer Immunotherapy

Edited by Samir A. Farghaly

Description

Ovarian Cancer Immunotherapy provides a broad overview of several aspects of basic sciences, and clinical and therapeutic aspects of immunotherapy for ovarian cancer, as well as state-of-the-art information on molecular genetics and biology. Chapters are written by a team of expert contributors from around the world and explore topics such as antibody therapeutics for ovarian carcinoma, emerging serum biomarkers, ovarian cancer immunity, adoptive cell immunotherapy, the biology of dendritic cells, the role of growth factors, and more. Readers will also gain a better understanding of the molecular and cellular events that underlie ovarian cancer immunology. This book is an ideal resource for clinicians, basic medical scientists, graduate basic medical science students, and medical students caring for patients with ovarian cancer, including attending surgeons and physicians, and clinical fellows and residents in the disciplines of gynecologic oncology, medical oncology, and surgical oncology.

Ovarian Cancer Immunotherapy

Edited by Samir A. Farghaly

Chapter 1: Antibody Therapeutics for Ovarian Carcinoma and Translation to the Clinic
Debra H. Josephs, Heather J. Bax, Giulia Pellizzari, James F. Spicer, Ana Montes, and Sophia N. Karagiannis
Chapter 2: Biological Aspects and Clinical Applications of Serum Biomarkers in Ovarian Cancer
Rouba Ali- Fehmi and Eman Abdulfatah
Chapter 3: Ovarian Cancer Immunity: How Does Immune Suppression Grow Cancer?
Vincent Lavoué, Patrick Legembre, Jean Levêque, Fabrice Foucher, Sébastien Henno, and Florian Cabillic
Chapter 4: Ovarian Tumor Microenvironment and Innate Immune Recognition
Jocelyn Reader, Sarah Lynam, Amy Harper, Gautam Rao, Maya Matheny, and Dana M. Roque
Chapter 5: Adoptive Cell Immunotherapy for Epithelial Ovarian Cancer
Samir A. Farghaly
Chapter 6: Antibody-based Therapy for Ovarian Cancer
Yousef Alharbi, Manish S. Patankar, and Rebecca J. Whelan
Chapter 7: Epitope/Peptide-based Monoclonal Antibodies for Immunotherapy of Ovarian Cancer
Gregory Lee
Chapter 8: Dendritic Cell Vaccine Therapy for Ovarian Cancer
Caitlin Stashwick, Brian J. Czerniecki, Janos L. Tanyi
Chapter 9: Heat Shock Protein Vaccine Therapy for Ovarian Cancer
Hiroyuki Abe, Amane Sasada, Shigeki Tabata, and Minako Abe
Chapter 10: PD-1 /PDL-1 Inhibitors as Immunotherapy for Ovarian Cancer
Scott Moerdler and Xingxing Zang
Chapter 11: Growth Factors and Their Corresponding Receptors as Targets for Ovarian Cancer Therapy
Anca Maria Cimpean, Andreea Adriana Jitariu, and Marius Raica
Chapter 12: Unique Challenges Facing Immunotherapy of Metastatic Ovarian Cancer
Michelle N. Messmer, Colleen S. Netherby, and Scott I. Abrams
Chapter 13: Clinical Trials of Ovarian Cancer Immunotherapy and Future Directions
Justin M. Drerup, Curtis A. Clark, and Tyler J. Curiel

Ovarian Cancer Immunotherapy

Edited by Samir A. Farghaly

Author Information

Samir A. Farghaly, MD, PhD is a Professor Obstetrics and Gynecology at the Joan and Sanford I. Weill Medical College, Graduate School of Medical Sciences; Sandra and Edward Meyer Cancer Center; and New York-Presbyterian Hospital/Weill Cornell Medical Center in New York, NY. He received his MD and PhD in molecular biology from London University. Dr. Farghaly is the Founder and Editor-in Chief of Current Trends in Gynecologic Oncology, and The International Journal of Gynecological, Obstetrical, and Reproductive Medicine Research. He is a member of the editorial boards of 18 international medical journals on Gynecological Cancers, Gene Expression and Therapy, Women's Health, and Gynecology.

Contributors:

Eman Abdulfatah, MD
Resident
Division of Pathology
Detroit Medical Center
Detroit, MI

Hiroyuki Abe, MD, PhD
Director of Abe Cancer Clinic
Tokyo, Japan

Minako Abe, MD
Abe Cancer Clinic
Tokyo, Japan

Scott I. Abrams, PhD
Professor of Oncology
Department of Immunology
Roswell Park Cancer Institute (RCPI)
Buffalo, NY

Yousef Alharbi, MS
Doctoral Candidate
Endocrinology and Reproductive Physiology Graduate Program
Department of Obstetrics and Gynecology
University of Wisconsin-Madison
Madison, WI

Heather J. Bax, PhD
St. John's Institute of Dermatology
Division of Genetics and Molecular Medicine
Division of Cancer Studies
Faculty of Life Sciences and Medicine
King's College London and NIHR Biomedical Research Centre
Guy's and St. Thomas' Hospital
King's College London
London, United Kingdom

Florian Cabillic, MCUPH
Cytogenetics and Cell Biology Laboratory
Rennes University Hospital Center
Rennes, France

Anca Maria Cimpean, MD, PhD
Department of Microscopic Morphology/Histology
Angiogenesis Research Center
Victor Babes University of Medicine and Pharmacy
Timisoara, Romania

Curtis A. Clark, MS
MD/PhD Candidate
Department of Microbiology, Immunology, and Molecular Genetics
University of Texas Health Science Center
San Antonio, TX

Tyler J. Curiel, MD, MPH
Department of Medicine
Department of Cell Systems and Anatomy
School of Medicine
Cancer Therapy and Research Center
University of Texas Health Science Center
San Antonio, TX

Brian J. Czerniecki, MD, PhD
Chair and Senior Member
Department of Breast Oncology
Moffitt Cancer Center
Tampa, FL
Emeritus Professor CE Of Surgery
Department of Surgery
University of Pennsylvania
Perelman School of Medicine
Philadelphia, PA

Justin M. Drerup
MD/PhD candidate
Department of Cell Systems and Anatomy
School of Medicine
University of Texas Health Science Center
San Antonio, TX

Rouba Ali- Fehmi, MD
Professor
Director of the GYN Oncology Tissue Procurement Program
Director of Surgical Pathology Fellowship Program
Department of Pathology
Wayne State University School of Medicine
Detroit, MI

Fabrice Foucher, MD
Department of Gynecology
Rennes University Hospital Center
Rennes, France

Amy Harper, MD
Department of Obstetrics, Gynecology & Reproductive Sciences
University of Maryland Medical Center
Baltimore, MD

Sébastien Henno, MD
Anatomy and Pathology Cytology Department
Rennes University Hospital Center
Rennes, France

Andreea Adriana Jitariu, PhD
Assistant Professor
Department of Microscopic Morphology/Histology
Angiogenesis Research Center
Victor Babes University of Medicine and Pharmacy
Timisoara, Romania

Debra H. Josephs, BSc, MBChB, MRCP, PhD
NIHR Academic Clinical Lecturer in Medical Oncology
King's College London and NIHR Biomedical Research Centre
Guy's and St. Thomas' Hospital
London, United Kingdom

Sophia N. Karagiannis, PhD
Reader in Translational Cancer Immunology
Head of Cancer Antibody Discovery and Immunotherapy
King's College London and NIHR Biomedical Research Centre
Guy's and St. Thomas' Hospital
London, United Kingdom

Vincent Lavoué, MD, PhD
Department of Gynecology
Rennes University Hospital Center
Rennes, France

Gregory Lee, PhD
Professor Emeritus of the University of British Columbia
Vancouver Coastal Health Research Institute
Vancouver, Canada

Patrick Legembre, PhD
Research Director
Oncogenesis Stress Signaling Lab
Rennes University Hospital Center
Rennes, France

Jean Levêque, MD, PhD
Head of Gynecological Service
Surgeon of the Oncological Surgical Unit of Rennes CLC
Rennes University Hospital Center
Rennes, France

Sarah Lynam, MD
Gynecologic Oncology Fellow
Roswell Park Cancer Institute (RCPI)
Buffalo, NY

Maya Matheny, PhD
Division of Gynecologic Oncology
University of Maryland Medical Center
Baltimore, MD

Michelle N. Messmer, PhD
Senior Fellow
Department of Immunology
University of Washington Seattle
Seattle, WA

Scott Moerdler, MD
Department of Microbiology and Immunology
Albert Einstein College of Medicine
Department of Pediatrics
Montefiore Medical Center
New York, NY

Ana Montes, MD
Consultant for Lung and Gynaecology
Department of Medical Oncology
Guy's and St Thomas' NHS Foundation Trust
London, United Kingdom

Colleen S. Netherby, PhD
Department of Immunology
Roswell Park Cancer Institute
Buffalo, NY

Manish S. Patankar, PhD
Associate Professor
Department of Obstetrics and Gynecology
University of Wisconsin-Madison
Madison, WI

Giulia Pellizzari, MSc
Research Student
King's College London and NIHR Biomedical Research Centre
Guy's and St. Thomas' Hospital
London, United Kingdom

Marius Raica, MD, PhD
Department of Microscopic Morphology/Histology
Angiogenesis Research Center
Victor Babes University of Medicine and Pharmacy
Timisoara, Romania

Gautam Rao, MD
Division of Gynecologic Oncology
University of Maryland Medical Center
Baltimore, MD

Jocelyn Reader, PhD
Division of Gynecologic Oncology
University of Maryland Medical Center
Baltimore, MD

Dana M. Roque, MD
Assistant Professor
Division of Gynecologic Oncology
University of Maryland Medical Center
Baltimore, MD

Amane Sasada, MD
Abe Cancer Clinic
Tokyo, Japan

James F. Spicer, MRCP, PhD, FCRP
Professor of Experimental Cancer Medicine
Division of Cancer Studies
Faculty of Life Sciences and Medicine
King's College London
Guy's and St. Thomas' Hospital
London, United Kingdom

Caitlin Stashwick, MD
Department of Obstetrics and Gynecology
University of Pennsylvania Health System
Lancaster General Health
Lancaster , PA

Shigeki Tabata, MD
Abe Cancer Clinic
Tokyo, Japan

Janos L. Tanyi, MD, PhD
Department of Obstetrics and Gynecology
University of Pennsylvania
Perelman Center for Advanced Medicine
Philadelphia, PA

Rebecca J. Whelan, PhD
Associate Professor and Chair
Department of Chemistry and Biochemistry
Oberlin College
Oberlin, OH

Xingxing Zang, PhD
Professor, Department of Microbiology & Immunology
Professor, Department of Medicine (Oncology)
Albert Einstein College of Medicine
New York, NY