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Published: 12 February 1998

216 Pages | 49 line illus.

6-1/8 x 9-1/4 inches

ISBN: 9780195068771

Bookseller Code (05)


Non-Mendelian Genetics in Humans

Harry Ostrer

Oxford Monographs on Medical Genetics

This book addresses the basic mechanisms for the transmission of genetic disorders in humans, and explores the evidence for a number of non-Mendelian genetic processes such as gonadal and somatic mosaicism, sex-linked inheritance, mitochondrial transmission, genomic imprinting, accelerated rates of mutation, and viral infection. In additional to an examination of the molecular basis for these processes and their effects on transmission and phenotype, the authors show how they resolve many of the exceptions to Mendelian inheritance. The book includes a complete review of Mendelian genetics and an overview on the structure and function of genes, chromosomes, and their products. transmission of genetic disorders in humans, stressing such non-Mendelian processes as mitochondrial inheritance, genomic imprinting and dynamic mutation.

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