Neuroscientific Foundations of Anesthesiology

Edited by George A. Mashour and Ralph Lydic

Uniquely covers anesthesiology as a neuroscientific field
Extensive chapters are organized by systems for easy understanding
An invaluable resource for both clinicians and scientists in anesthesiology and neuroscience
Covers anesthetic neurotoxicity, a topic of current controversy and importance

Neuroscientific Foundations of Anesthesiology

Edited by George A. Mashour and Ralph Lydic

Description

Although the perioperative care of patients by anesthesiologists draws on diverse clinical skills, the principles of anesthesiology and pain management are rooted in the neurosciences. The Neuroscientific Foundations of Anesthesiology thoroughly examines the anesthetic modulation of the central, peripheral, and autonomic nervous systems and will help redefine anesthesiology as a fundamentally neuroscientific field. The book is organized by sections, with each focusing on a different part of the nervous system. State-of-the-art chapters written by thought-leaders in anesthesiology and neuroscience provide a novel and invaluable resource.

Neuroscientific Foundations of Anesthesiology

Edited by George A. Mashour and Ralph Lydic

I. Introduction

II. Brain

1. Brain Anatomy of Relevance to the Anesthesiologist

2. Cellular and Molecular Effects of General Anesthetics in the Brain

3. The Shared Circuits of Sleep and Anesthesia

4. Thalamocortical System and Anesthetic-induced Unconsciousness

5. Anesthetic Modulation of Memory Processing in the Medial Temporal Lobe

6. Neuroimaging Changes Associated with Human Acute and Chronic Pain

III. Spinal Cord

7. Spinal Cord Targets of Relevance to the Anesthesiologist

8. Anesthetic-Induced Immobility

9. Mechanisms of Spinal Analgesia

IV. Peripheral Nervous System

10. Peripheral Nervous System: Anatomy and Function

11. The Neurobiology of Incisional Pain

12. Sequelae of Nerve injury: Neuropathic Pain and Complex Regional Pain Syndrome

V. Autonomic Nervous System

13. The Autonomic Nervous System

14. Anesthetic Pharmacology of the Autonomic Nervous System

VI. Neuromuscular Junction

15. Review of neuromuscular junction anatomy and function

16. Pharmacology of Neuromuscular Blockers

17. Anesthesia and Disorders of the Neuromuscular System

VII. Neural Toxicity Induced by Anesthetics

18. Anesthesia-mediated neurotoxicity

19. Post-Operative Cognitive Disorders

20. Anesthesia and Neurodegenerative Disorders

Index

Neuroscientific Foundations of Anesthesiology

Edited by George A. Mashour and Ralph Lydic

Author Information

George Mashour: Director, Division of Neuroanesthesiology; Assistant Professor of Anesthesiology and Neurosurgery; Faculty, Neuroscience Graduate Program; Faculty, Center for Sleep Medicine; University of Michigan Medical School & Graduate School, Ann Arbor, Michigan

Ralph Lydic: Bert La Du Professor of Anesthesiology, Department of Anethesiology, University of Michigan Medical School, Ann Arbor, Michigan

Contributors:

Michael T. Alkire, MD
Staff Physician
VA Long Beach Health Care System
Long Beach, CA
and
Associate Professor in Residence,
Department of Anesthesiology & Perioperative Care
Fellow, Center for the Neurobiology of Learning and Memory
University of California, Irvine
Irvine, CA

Timothy Angelotti, MD, PhD
Associate Professor
Department of Anesthesia/CCM
Stanford University School of Medicine
Stanford, CA

Joseph F. Antognini, MD, MBA
Professor of Anesthesiology and Pain Medicine
Professor of Neurobiology, Physiology and Behavior
University of California, Davis School of Medicine
Davis, CA

Helen A. Baghdoyan, PhD
Director of Laboratory Research
Professor of Anesthesiology
Professor of Pharmacology
University of Michigan
Ann Arbor, MI

Robert Bonin, PhD
Department of Physiology
University of Toronto
Toronto, Ontario, Canada

Timothy J. Brennan, PhD, MD
Samir Gergis Professor and Vice Chair for Research
Departments of Anesthesia and Pharmacology
University of Iowa Hospitals and Clinics
Iowa City, IA

Sorin J. Brull, MD
Professor of Anesthesiology
Mayo Clinic College of Medicine
Jacksonville, FL

Chad M. Brummett, MD
Assistant Professor
Department of Anesthesiology
Director, Adult Pain Research
University of Michigan Medical School
Ann Arbor, MI

Adam J. Carinci, MD
Instructor
Division of Pain Medicine
Department of Anesthesia, Critical Care and Pain Medicine
Harvard Medical School
Massachusetts General Hospital
Boston, MA

Daniel J. Clauw, MD
Professor
Division of Rheumatology
Director, Chronic Pain and Fatigue Research Center
University of Michigan Medical School
Ann Arbor, MI

François Donati, PhD, MD, FRCPC
Professor
Department of Anesthesiology
Université de Montréal
Staff anesthesiologist
Hôpital Maisonneuve-Rosemont
Montréal, Québec, Canada

Michael Erdek, MD
Assistant Professor
Department of Anesthesiology and Critical Care Medicine and Oncology
Director of Quality Improvement
Department of Anesthesiology
Division of Pain Medicine
Johns Hopkins University School of Medicine
Baltimore, MD

David B. Glick, MD, MBA
Associate Professor
Anesthesia and Critical Care
University of Chicago, Pritzker School of Medicine
Chicago, IL

Gerald Glick, MD
Professor Emeritus of Medicine
Rush Medical College
Chicago, IL

Haroon Hameed, MD
Fellow
Division of Pain Medicine
Department of Anesthesia and Critical Care Medicine
Johns Hopkins University, School of Medicine
Baltimore, MD

Mariam Hameed, MD
Resident
Department of Physical Medicine and Rehabilitation
Johns Hopkins University, School of Medicine
Baltimore, MD

Richard E. Harris, PhD
Assistant Professor of Anesthesiology
Chronic Pain and Fatigue Research Center
University of Michigan
Ann Arbor, MI

Anthony G. Hudetz, DBM, PhD
Professor of Anesthesiology, Physiology and Biophysics
Department of Anesthesiology
Medical College of Wisconsin
Milwaukee, WI

Vesna Jevtovic-Todorovic, MD, PhD, MBA
Harold Carron Professor of Anesthesiology and Neuroscience
Department of Anesthesiology and Neuroscience
University of Virginia Health System
Charlottesville, VA

Steven L. Jinks, PhD
Adjunct Assistant Professor of Anesthesiology and Pain Medicine
University of California, Davis School of Medicine
Davis, CA

Mihir M. Kamdar, MD
Co-Director
Massachusetts General Hospital Cancer Pain Clinic
and
Instructor
Division of Pain Medicine
Department of Anesthesia, Critical Care and Pain Medicine
Harvard Medical School
Massachusetts General Hospital
Boston, MA

Sinyoung Kang, MD, PhD
Clinical Fellow in Regional Anesthesia
Department of Anesthesia
University of Iowa Hospitals and Clinics
Iowa City, IA

Smith C. Manion, MD
Instructor
Division of Pain Medicine
Department of Anesthesia, Critical Care and Pain Medicine
Harvard Medical School
Massachusetts General Hospital
Boston, MA

Jianren Mao, MD, PhD
Director, MGH Center for Translational Pain Research
Associate Professor, Harvard Medical School
Division of Pain Medicine
Department of Anesthesia, Critical Care and Pain Medicine,
Massachusetts General Hospital
Harvard Medical School
Boston, MA

Terri G. Monk, MD, MS
Professor
Department of Anesthesiology
Duke University Medical Center
Durham VA Medical Center
Durham, NC

Mohamed Naguib, MB, BCh, MSc, FFARCSI, MD
Professor of Anesthesiology
Department of Anesthesiology and Pain Medicine
The University of Texas MD Anderson Cancer Center
Houston TX

Dhananjay Namjoshi, M Pharm, MSc
Graduate Student (Neuroscience Program)
Faculty of Medicine
The University of British Columbia
Vancouver, Canada

Beverley A. Orser, MD, PhD
Canada Research Chair in Anesthesia
Professor, Departments of Anesthesia and Physiology
University of Toronto
and
Department of Anesthesia
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada

Catherine C. Price, PhD
Assistant Professor
Clinical and Health Psychology &
Department of Anesthesiology
University of Florida
Gainesville, FL

Kane O. Pryor, MD
Assistant Professor of Anesthesiology
Assistant Professor of Anesthesiology in Psychiatry
Weill Cornell Medical College
New York, NY

Srinivasa Raja, MD
Professor
Department of Anesthesiology and Critical Care Medicine and Oncology
Division Chief
Department of Anesthesiology
Division of Pain Medicine
Johns Hopkins University School of Medicine
Baltimore, MD

Raul Sanoja, MD, PhD
Research Associate
Faculty of Pharmaceutical Sciences
The University of British Columbia
Vancouver, Canada

Tobias Schmidt-Wilcke, MD
Department of Neurology
University of Regensburg
Regensburg, Germany

Peter J. Soja, PhD
Professor, Pharmacology & Neuroscience
Faculty of Pharmaceutical Sciences
The University of British Columbia
Vancouver, Canada

Jared J. Tanner, MS
Graduate Student
Clinical & Health Psychology
University of Florida
Gainesville, FL

Pablo Torterolo, MD, PhD
Assistant Professor
Department of Physiology
School of Medicine
Universidad de la República
Montevideo, Uruguay

Giancarlo Vanini, MD
Research Investigator
Department of Anesthesiology
University of Michigan
Ann Arbor, MI

Robert A. Veselis, MD
Professor of Clinical Anesthesiology
Memorial Sloan-Kettering Cancer Center
New York, NY

Sanja Vukicevic, BSc Pharm, RPh
Medical Student
Faculty of Medicine
The University of British Columbia
Vancouver, Canada
Marnie B.Welch, MD
Staff Anesthesiologist
Department of Anesthesiology
Gundersen Lutheran Hospital
Lacrosse, WI

Zhongcong Xie, MD, PhD
Associate Professor of Anaesthesia
Harvard Medical School
Boston, MA

Jun Xu, MD, PhD
Senior Scientist
Neuroscience Research
Global Pharmaceutical Research and Development
Abbott Laboratories
Abbott Park, IL

Yiying (Laura) Zhang, MD, MS
Research Fellow of Anaesthesia
Harvard Medical School
Boston, MA