Molecular Biology and Pathology of Paediatric Cancer

Edited by Catherine J. Cullinane, Susan A. Burchill, Jeremy A. Squire, John J. O'Leary, and Ian J. Lewis

The editorial team combines both scientific and clinical expertise and an international list of contributors
The molecular study of paediatric tumours have contributed enormously to our understanding of the pathogenesis of paediatric oncology

Molecular Biology and Pathology of Paediatric Cancer

Edited by Catherine J. Cullinane, Susan A. Burchill, Jeremy A. Squire, John J. O'Leary, and Ian J. Lewis

Description

There has been an explosion of knowledge and enormous progress in the fundamental understanding of the biology of cancer in recent years. This has included the realisation that cancer occurs when normal cellular functions are disturbed leading to a malignant phenotype. Much research has focused on understanding the types of disturbances that can occur, the contribution that these abnormalities can make to the development and behavior of particular cancers and more recently, the recognition that these cellular and genetic abnormalities can provide rational targets for new therapeutic approaches. Information about the biology of cancers that occur in children has increased in parallel with these more general advances and this book is intended to provide a focus for readers who wish to have an understanding of our current state of knowledge.

An international group of editors and contributors provide guidelines on the molecular biology and pathology of paediatric oncology, aimed at clinicians and scientists working in the specialty who wish to understand current developments in molecular pathology as applied to their field. The book is broad ranging review focusing on the impact of molecular and cytogenetic techniques on our understanding of the aetiology, clinical behaviour, diagnosis and management of paediatric cancer. The first section outlines the laboratory handling of tissue samples, theory and methodology of cytogenetic and molecular techniques and discusses predisposition syndromes. The second section highlights the application of cytogenetic and molecular methods in diagnosis and treatment of the major paediatric cancers.

Molecular Biology and Pathology of Paediatric Cancer

Edited by Catherine J. Cullinane, Susan A. Burchill, Jeremy A. Squire, John J. O'Leary, and Ian J. Lewis

1. Introduction to children's cancer and the patient experience, IJ Lewis
2. Cells, tissues and the diagnostic laboratory, C Cullinane, SA Burchill & JJ O'Leary
3. Methods of genetic analysis applied to pediatric cancer, J Bayani, M Zielenska & JA Squire
4. Blots, dots, amplification and sequencing, JJ O'Leary, C Martin & O Shiels
5. Familial and predisposition syndromes, EG Sheridan & CG Woods
6. Leukaemia, S Weitzman & JA Squire
7. Lymphoma, MV Gresik
8. Tumours of central nervous system and eye, V Jay, M Zielenska & JA Squire
9. Neuroblastoma, S Variend & SA Burchill
10. Primitive neuroectodermal tumours, C Cullinane & SA Burchill
11. Rhabdomyosarcoma, I Leuschner
12. Soft tissue tumours (excluding rhabdomyosarcoma and primitive neuroectodermal tumours), JR Thomas & DM Parham
13. Renal tumours, P Argani & EJ Perlman
14. Bone tumours (excluding Ewing's sarcoma), W Bell & GP Siegal
15. Germ cell tumours, ES Gray
16. Liver tumours, MJ Finegold
17. Carcinoma, C Cullinane & JJ O'Leary

Molecular Biology and Pathology of Paediatric Cancer

Edited by Catherine J. Cullinane, Susan A. Burchill, Jeremy A. Squire, John J. O'Leary, and Ian J. Lewis

Author Information

Contributors:

Pedram Argani, Paediatric Pathologist, The National Wilms Tumor Study Group Pathology Center, Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, USA

Jane Bayani, University Health Network, Ontario Cancer Institute and the Departments of Laboratory Medicine and Pathobiology, and Medical Biophysics, University of Toronto, Canada

W. Bell, Division of Pathology, The University of Alabama at Birmingham, USA

Susan A. Burchill, Senior Scientist, Candlelighter's Children's Cancer Research Laboratory, ICRF Cancer Medicine Research Unit, St James's University Hospital, Leeds, UK

Catherine Cullinane, Paediatric Pathologist, Department of Pathology, St James's University Hospital, Leeds, UK

Milton J. Finegold, Professor of Pathology and Paediatrics, Department of Pathology, Texas Children's Hospital, Houston, USA

Mary V. Gresik, Associate Professor of Pathology, Baylor College of Medicine, Houston, USA

Elizabeth S. Gray, Paediatric Pathologist, Department of Pathology, University of Aberdeen, UK

Venita Jay, Associate Professor, Departments of Laboratory Medicine and Pathobiology and Ophthalmololgy, The University of Toronto, and Neuropathologist and ophthalmic pathologist, The Hospital for Sick Children and Women's College Hospital, Toronto, Ontario, Canada

Ivo Leuschner, Pathologist, Institut fur Paidpathologie, Universitatslinikum Kiel, Germany

Ian A. Lewis, Paediatric Oncologist, Department of Paediatric Oncology, Yorkshire Regional Paediatric Oncology Service, St James's University Hospital, Leeds, UK

Cara Martin, Pathology Department, Coombe Maternity Hospital, Dublin, Ireland

John J. O'Leary, Pathologist, Pathology Department, Coombe Maternity Hospital, Dublin, Ireland

David M. Parham, Pediatric Pathologist, Departments of Pathology, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, USA

Elizabeth J. Perlman, Pediatric Pathologist, The National Wilms Tumor Study Group Pathology Center, Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, USA

Orla Shiels, Pathology Department, Coombe Maternity Hospital, Dublin, Ireland

Eamonn G. Sheridan, Clinical Geneticist, Yorkshire Regional Genetics Service, St James's University Hospital, Leeds UK

Gene P. Siegal, Professor of Pathology, Cell Biology and Surgery, Division of Pathology, The University of Alabama at Birmingham, USA

J. A. Squire, Faculty of Medicine, University of Toronto, Toronto, Canada

J. Robert Thomas, Pathologist, Departments of Pathology, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, USA

Sadik Variend, Paediatric Pathologist, Department of Pathology, Sheffield Children's Hospital, Sheffield UK

Sheila Weitzman, Pediatric Oncologist, Department of Oncology, The Hospital for Sick Children, Toronto, Canada

C. Geoffrey Woods, Clinical Geneticist, Yorkshire Regional Genetics Service, St James's University Hospital, Leeds UK

Maria Zielenska, Assistant Professor, Department of Laboratory Medicine and Pathobiology, The University of Toronto and Molecular Diagnostics, Hospital for Sick Children, Toronto, Canada