Late-Life Mood Disorders

Dr. Helen Lavretsky is a Professor of Psychiatry at the Semel Institute for Neuroscience and Human Behavior at UCLA, a geriatric psychiatrist with the research interest in geriatric depression and caregiver stress, as well as complementary and alternative medicine and mind-body approaches to treatment and prevention of disorders in older adults. She is a recipient of the two Career Development awards from NIMH and other prestigious research awards. Her current research include clinical and translational studies of geriatric depression and caregiver stress, as well as complementary and alternative interventions for stress reduction in older adults.

Dr. Sajatovic is Professor of Psychiatry at Case Western Reserve University School of Medicine in Cleveland, Ohio. She is a researcher, educator, and clinician who has devoted herself to the study and treatment of traditionally hard-to treat populations with serious mental illness. Dr. Sajatovic is Director of Geropsychiatry at University Hospitals Case Medical Center (UHCMC) and holds the Willard Brown Chair in Neurological Outcomes at UHCMC/Case Western Reserve University School of Medicine.

Dr. Charles F. Reynolds III, M.D. is the UPMC Professor of Geriatric Psychiatry; and professor of neurology and neuroscience; Senior Associate Dean University of Pittsburgh School of Medicine; and professor of behavioral and community health sciences at the University of Pittsburgh Graduate School of Public Health. The recipient of a National Institute of Mental Health (NIMH) Research Scientist Award and a MERIT award for studies of "Maintenance Therapies in Late Life Depression," Dr. Reynolds has twice been named one of The Best Doctors in America and has received the Exemplary Psychiatrist Award from the National Alliance for the Mentally Ill.

Contributors

Howard J. Aizenstein, MD, PhD
Department of Psychiatry and Clinical and Translational Sciences
University of Pittsburgh School of Medicine; and
Department of Bioengineering
University of Pittsburgh
Pittsburgh, PA

Olusola Ajilore, MD, PhD
Department of Psychiatry
University of Illinois-Chicago
Chicago, IL

Osvaldo P. Almeida, PhD
Centre forMedical Research
The University of Western Australia
Crawley, WA Australia

David Ames, MD, FRCPsych, FRANZCP
Department of Ageing and Health
University of Melbourne; and
National Ageing Research Institute
Royal Melbourne Hospital
Parkville, Victoria, Australia

Stewart Anderson, PhD
Department of Biostatistics
University of Pittsburgh
Pittsburgh, PA

Patricia A. Arean, PhD
Department of Psychiatry
University of California, San Francisco
San Francisco, CA

Chiara Baglioni, PhD
Department of Psychiatry and Psychotherapy
Freiburg University Medical Center
Germany

Kisha N. Bazelais, PhD
Department of Psychiatry
Weill Cornell Medical College
White Plains, NY

Aartjan T.F. Beekman, MD
Department of Psychiatry; and
EMGO Institute for Care and Health Research
VU University Medical Centre
Amsterdam, The Netherlands


Mathias Berger, MD
Department of Psychiatry and Psychotherapy
Freiburg University Medical Center
Germany

Robert R. Bies, PharmD, PhD
School of Pharmacy
University of Pittsburgh
Pittsburgh, PA

Kristin L. Bigos, PhD
School of Pharmacy
University of Pittsburgh
Pittsburgh, PA

Martha L. Bruce, PhD, MPH
Department of Psychiatry
Weill Cornell Medical College
White Plains, NY

Meryl A. Butters, PhD
Department of Psychiatry
University of Pittsburgh School of Medicine
Pittsburgh, PA

Hannah Carliner, MPH
Department of Society, Human Development and Health
Harvard School of Public Health
Boston, MA

Ji-in Choi
Department of Biostatistics
University of Pittsburgh
Pittsburgh, PA

Alex Cohen, PhD
Faculty of Epidemiology and Population Health
London School of Hygiene and Tropical Medicine
London, UK

Sean J. Colloby, PhD
Institute for Ageing and Health
Newcastle University
Campus for Ageing and Vitality
Newcastle upon Tyne, UK

Yeates Conwell, MD
Department of Psychiatry
University of Rochester School of Medicine and Dentistry; and
Center for the Study of the Prevention of Suicide
Rochester, NY

Pim Cuipers, PhD
Department of Clinical Psychology; and
EMGO Institute for Care and Health Research
VU University Medical Centre
Amsterdam, The Netherlands

Jeffrey Cummings, MD
Cleveland Clinic Lou Ruvo Center for Brain Health
Las Vegas, NV

Bevin Demuth, MSW
Department of Psychiatry and Behavioral Sciences,
Stanford University School of Medicine
Stanford, CA; and
Sierra-Pacific Mental Illness research and Education Center
Department of Veterans Affairs
Palo Alto, CA

Abhilash K. Desai, MD
Department of Neurology and Psychiatry
Saint Louis University School of Medicine
St. Louis, MO

Jaime Deseda
Department of Psychiatry
Harvard Medical School
McLean Hospital
Belmont, MA

Mary Amanda Dew, PhD
Departments of Psychiatry, Psychology, Epidemiology, Biostatistics and
Clinical and Translational Science
University of Pittsburgh School of Medicine
Pittsburgh, PA

Briony Dow, PhD
National Ageing Research Institute
Royal Melbourne Hospital
Parkville, Victoria, Australia

Paul Duberstein, PhD
Department of Psychiatry
University of Rochester Medical Center
Rochester, NY

Jovier D. Evans, PhD
Geriatrics Research Branch
National Institute of Mental Health
National Institutes of Health
Bethesda, Maryland

John Flournoy
Department of Psychiatry and Behavioral Sciences,
Stanford University School of Medicine
Stanford, CA; and
Sierra-Pacific Mental Illness research and Education Center
Department of Veterans Affairs
Palo Alto, CA

Brent Forester, MD
Department of Psychiatry
Harvard Medical School
McLean Hospital
Belmont, MA

Joseph J. Gallo, MD, MPH
Department of Family Medicine and Community Health
Penn Presbyterian Medical Center
Philadelphia, PA

Linda Garand, PhD
Department of Health & Community Systems
University of Pittsburgh School of Nursing
Pittsburgh, PA

Anda Gershon, PhD
Department of Psychiatry and Behavioral Sciences,
Stanford University School of Medicine
Stanford, CA; and
Sierra-Pacific Mental Illness research and Education Center
Department of Veterans Affairs
Palo Alto, CA

Angela Ghesquiere, MSW
Columbia University School of Social Work
New York, NY

Stephen E. Gilman, ScD
Departments of Society, Human Development and Health and Epidemiology
Harvard School of Public Health; and
Department of Psychiatry
Massachusetts General Hospital
Boston, MA

George T. Grossberg, MD
Departments of Neurology & Psychiatry, Anatomy and Neurobiology
and Internal Medicine
Saint Louis University School of Medicine
St. Louis, MO

Betty Haralambous, MSW
National Ageing Research Institute
Royal Melbourne Hospital
Parkville, Victoria, Australia

Amy Helstrom, PhD
Department of Psychiatry
Philadelphia VA Medical Center; and
Mental Illness Research, Education, and Clinical Center (MIRECC)
Philadelphia, PA

Christina Hui, MD
Department of Psychiatry and Biobehavioral Sciences
David Geffen School of Medicine at UCLA; and
VA Greater Los Angeles Healthcare System
Los Angeles, CA

Michael R. Irwin, MD
Cousins Center for Psychoneuroimmunology
Semel Institute for Neuroscience
University of California, Los Angeles
Los Angeles, CA

Dilip V. Jeste, MD
Department of Psychiatry; and
Sam and Rose Stein Institute for Research on Aging
University of California, San Diego, CA

Helen C. Kales, MD
National VA Serious Mental Illness Treatment Resource & Evaluation Center (SMITREC); and
Department of Psychiatry
University of Michigan Health System
Ann Arbor, MI

Jordan F. Karp, MD
Departments of Psychiatry, Anesthesiology, and
Clinical and Translational Science
Western Psychiatric Institute and Clinic
University of Pittsburgh School of Medicine
Pittsburgh, PA

Michael S. Katzke
Columbia University School of Social Work
New York, NY

Janet Kavanagh
Department of Psychiatry
University of Michigan Health System
Ann Arbor, MI

Anand Kumar, MD
Department of Psychiatry
University of Illinois-Chicago
Chicago, IL

Ganesh Kulkarni, MBBS
San Diego State University
San Diego, CA

Helen Lavretsky, MD
Department of Psychiatry and Biobehavioral Sciences
Semel Institute for Neuroscience and Human Behavior
David Geffen School of Medicine at UCLA
Los Angeles, CA

Eric J. Lenze, MD
Department of Psychiatry
Washington University School of Medicine
St. Louis, MO

Xiaoping Lin
National Ageing Research Institute
Royal Melbourne Hospital
Parkville, Victoria, Australia

Daphne T. Lo, MD
Department of Internal Medicine
University of Colorado, Denver
Aurora, CO

Constantine G. Lyketsos, MD, MHS
Department of Psychiatry and Behavioral Sciences
Johns Hopkins Bayview Medical Center
Baltimore, MD

Jeffrey M. Lyness, MD
Department of Psychiatry
University of Rochester Medical Center
Rochester, NY

Nahla A. Mahgoub, MD
Department of Psychiatry
Weill Cornell Medical College
White Plains, NY

Susan M. Maixner, MD
Department of Psychiatry
University of Michigan Health System
Ann Arbor, MI

Christopher M. Marano, MD
Department of Psychiatry and Behavioral Sciences
Johns Hopkins Bayview Medical Center
Baltimore, MD

Patricia Marino, PhD
Department of Psychology
Weill Cornell Medical College
White Plains, NY

William M. McDonald, MD
Department of Psychiatry and Behavioral Sciences
Emory University School of Medicine
Atlanta, GA

Jonathan McGovern
Western Psychiatric Institute and Clinic
University of Pittsburgh School of Medicine
Pittsburgh, PA

Thomas W. Meeks
Department of Psychiatry
University of California, San Diego, CA

David Merrill, MD, PhD
Department of Psychiatry and Biobehavioral Sciences
Semel Institute for Neuroscience and Human Behavior
David Geffen School of Medicine at UCLA
Los Angeles, CA

Briana Mezuk, PhD
Department of Epidemiology and Community Health
Virginia Commonwealth University
Richmond, VA

José Javier Miguel-Hidalgo, PhD
Department of Psychiatry and Human Behavior
University of Mississippi Medical Center
Jackson, MS

Greer M. Murphy, Jr., MD, PhD
Department of Psychiatry and Behavioral Sciences
Stanford University School of Medicine
Stanford, CA

J. Craig Nelson, MD
Department of Psychiatry
University of California, San Francisco
San Francisco, CA

George T. Niederehe, PhD
Geriatrics Research Branch
National Institute of Mental Health
National Institutes of Health
Bethesda, Maryland

John T. O'Brien, DM
Institute for Ageing and Health
Newcastle University
Campus for Ageing and Vitality
Newcastle upon Tyne, UK

Ruth O'Hara, PhD
Department of Psychiatry and Behavioral Sciences,
Stanford University School of Medicine
Stanford, CA; and
Sierra-Pacific Mental Illness research and Education Center
Department of Veterans Affairs
Palo Alto, CA

Alisa O'Riley, PhD
Department of Psychiatry
University of Rochester School of Medicine and Dentistry; and
Center for the Study of the Prevention of Suicide
Rochester, NY

David W. Oslin, MD
Department of Psychiatry
Philadelphia VA Medical Center; and
Mental Illness Research, Education, and Clinical Center (MIRECC)
Philadelphia, PA

Mijung Park, PhD, MSN
Department of Psychiatry and Behavioral Sciences
University of Washington School of Medicine
Seattle, WA

Meenal J. Patel
Department of Bioengineering
University of Pittsburgh
Pittsburgh, PA

Martha Payne, PhD, RD, MPH
Department of Psychiatry and Behavioral Sciences
Neuropsychiatric Imaging Research Laboratory
Duke University School of Medicine
Durham, NC

Roger Peele, MD, DLFAPA
Behavioral Health and Crisis Center Montgomery County
Rockville, MD

Andrew J. Petkus
San Diego State University; and
University of California, San Diego, CA

Yolonda R. Pickett, MD
Department of Psychiatry and Behavioral Sciences
Albert Einstein School of Medicine
Bronx, NY

Bruce G. Pollock, MD, PhD
Departments of Psychiatry and Pharmacology
University of Toronto, CA

Grazyna Rajkowska, PhD
Department of Psychiatry and Human Behavior
University of Mississippi Medical Center
Jackson, MS

Charles F. Reynolds III, MD
Western Psychiatric Institute and Clinic
University of Pittsburgh School of Medicine
Pittsburgh, PA

Dieter Riemann, PhD
Department of Psychiatry and Psychotherapy
Freiburg University Medical Center
Germany

Heleen Riper, PhD
Departments of Clinical Psychology and Psychiatry; and
EMGO Institute for Care and Health Research
VU University Medical Centre
Amsterdam, The Netherlands

Emma Rhodes
Department of Psychiatry
University of Illinois-Chicago
Chicago, IL

Oliver J. Robinson, PhD
National Institute of Mental Health
Bethesda, MD

Paul B. Rosenberg, MD
Department of Psychiatry and Behavioral Sciences
Johns Hopkins Bayview Medical Center
Baltimore, MD

Barbara J. Sahakian, PhD
Department of Psychiatry
University of Cambridge; and
MRC/Wellcome Trust Behavioural and Clinical Neuroscience Institute
Cambridge, UK

Martha Sajatovic, MD
Departments of Psychiatry and Neurology; and
Neurological Outcomes Center
University Hospitals Case Medical Center
Cleveland, OH

Alan Schatzberg, MD
Department of Psychiatry and Behavioral Sciences,
Stanford University School of Medicine
Stanford, CA

Richard Schulz, PhD
Departments of Psychiatry, Epidemiology, Sociology, Psychology, Community Health,
& Health and Rehabilitation Sciences
University Center for Social and Urban Research; and
Aging Institute of UPMC Senior Services
University of Pittsburgh, PA

Katherine M. Shear, MD
Columbia University School of Social Work
New York, NY

Jo Anne Sirey, PhD
Department of Psychology
Weill Cornell Medical College
White Plains, NY

Elizabeth R. Skidmore, PhD
Department of Occupational Therapy
University of Pittsburgh School of Health & Rehabilitation Sciences
Pittsburgh, PA

Filip Smit, PhD
Department of Epidemiology and Biostatistics
EMGO Institute for Care and Health Research
VU University Medical Centre
Amsterdam, The Netherlands

Gwenn S. Smith, PhD
Department of Psychiatry and Behavioral Sciences
John Hopkins University School of Medicine
Baltimore, MD

John Snowdon, FRC Psych, FRANZCP, MD
Department of Psychological Medicine
Concord Clinical School
The University of Sydney
Sydney, Australia

David C. Steffens, MD
Department of Psychiatry
University of Connecticut Health Center
Farmington, CT

Keith Sudheimer, PhD
Department of Psychiatry and Behavioral Sciences,
Stanford University School of Medicine
Stanford, CA

David L. Sultzer, MD
Department of Psychiatry and Biobehavioral Sciences
David Geffen School of Medicine at UCLA; and
VA Greater Los Angeles Healthcare System
Los Angeles, CA

Wesley K. Thompson, PhD
Department of Psychiatry
University of California, San Diego
San Diego, CA

Jean Tinney, PhD
National Ageing Research Institute
Royal Melbourne Hospital
Parkville, Victoria, Australia

Jürgen Unützer, MD, MPH
Department of Psychiatry and Behavioral Sciences
University of Washington School of Medicine
Seattle, WA

Arshya Vahabzadeh, MD
Department of Psychiatry and Behavioral Sciences
Emory University School of Medicine
Atlanta, GA

Ipsit V. Vahia, MD
Department of Psychiatry; and
Sam and Rose Stein Institute for Research on Aging
University of California, San Diego, CA

Sarah Volk, MD
Department of Psychiatry
University of North Carolina School of Medicine
Chapel Hill, NC

Julie Loebach Wetherell, PhD
Department of Psychiatry
University of California, San Diego, CA

Ellen M. Whyte, MD
Departments of Psychiatry and Physical Medicine and Rehabilitation
University of Pittsburgh School of Medicine
Pittsburgh, PA

Dylan Wint, MD
Cleveland Clinic Lou Ruvo Center for Brain Health
Las Vegas, NV

Marsha Wittink, MD, MBE
Department of Psychiatry
University of Rochester Medical Center
Rochester, NY

Matthew Woodward
Department of Psychiatry
Harvard Medical School
McLean Hospital
Belmont, MA

Robert C. Young, MD
Department of Psychiatry
Weill Cornell Medical College
White Plains, NY

Kara Zivin, PhD
National VA Serious Mental Illness Treatment Resource & Evaluation Center (SMITREC); and
University of Michigan Health System
Ann Arbor, MI

"The editors of this volume, themselves well-known experts in late life mood disorders, have accumulated an amazingly diverse and competent group of authors for this effort. The result is what must be for years to come the go to volume for a comprehensive and critical review of this significant public health burden for elders. An additional strength of the volume is the appropriately broad range of topics covered, from the basic neuropathology underlying late life depression and its variants to an excellent review of care systems. Therapeutic modalities are not neglected and reflect significant advances in both individual therapies and integrative models now available to practitioners. In summary, this volume is not only up to date, it is also unique in its breadth and depth. A must reference for the geriatric mental health workforce." -- Dan G. Blazer MD, PhD, JP Gibbons Professor of Psychiatry and Behavioral Sciences, Duke University Medical Center

"As the number of people age 60 years and older triples over the next four decades, Late-Life Mood Disorders will become an essential resource not only for specialists and students, but also for general psychiatrists who will be seeing a greater number of older adults with geriatric mental disorders. The editors have brought together the leading experts in the field to provide a comprehensive, scholarly, and accessible volume that elucidates the relevant science and offers practical clinical guidance." -- Gary Small, M.D., Professor of Psychiatry and Biobehavioral Sciences and Parlow-Solomon Professor on Aging; Director of the Geriatric Psychiatry Division and the UCLA Longevity Center at the Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles

"The editors, who are among the leading researchers in this field, have done an outstanding job in bringing together the leading experts in the field of late-life mood disorders. The in-depth, up-to-date chapters incorporate a practical focus on clinical comorbidities and patient and caregiver issues, in addition to providing clear directions for future research in this fastest growing age group in the general population. This book represents an outstanding review of the current status of this field and should rapidly become the standard reference for mood disorders in the elderly." -- D.P. Devanand, MD, Professor of Clinical Psychiatry and Neurology, Director, Division of Geriatric Psychiatry, College of Physicians and Surgeons, Columbia University

"The demographic imperative of a rapidly rising elderly population with a high prevalence of mood disorders makes this a most compelling topic. Moreover, the old adage that "Geriatric Psychiatry is General Psychiatry only moreso" is exemplified by this textbook's comprehensive approach to complex late-life mood disorders...Comprehensive, convenient and current - this is an essential resource for students, clinicians, researchers and decision-makers. It provides a treasure trove of information on mood disorders in an important and growing patient population within a convenient, one-stop shopping textbook. Congratulations to the editors and to Oxford University Press." -- Kenneth I. Shulman, MD, FRCPsych, Richard Lewar Chair in Geriatric Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto

"This comprehensive book is an excellent guide to the current scientific knowledge about late-life mood disorders. All clinicians involved in the care of older adults should be familiar with the information it contains." -- Doody's

"This new textbook is an authoritative presentation of our current understanding of mood disorders in older people. It addresses a gap in the market by presenting an up-to-date overview of our current state of knowledge in an expanding field of research." -- Psychological Medicine